Human disease populations
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Single-cell transcriptome profiling has enabled highresolution analysis of cellular populations in tissues during development, health, and disease. Recent studies make innovative use of single-cell RNA sequencing (scRNAseq) to investigate mechanisms that allow immune cells to interact with tissue components in the lung during development and fibrotic lung disease.
3p vibransone 28-03-2024 8 2 Download
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Next-generation sequencing has allowed for the identification of different genetic variations, which are known to contribute to diseases. Of these, insertions and deletions are the second most abundant type of variations in the genome, but their biological importance or disease association is not well-studied, especially for deletions of intermediate sizes.
15p vibransone 28-03-2024 3 2 Download
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Quantifying tissue-infiltrating immune and stromal cells provides clinically relevant information for various diseases. While numerous methods can quantify immune or stromal cells in human tissue samples from transcriptomic data, few are available for mouse studies.
15p vibransone 28-03-2024 5 2 Download
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Several articles suggest that DNA methylation levels in blood relate to Parkinson’s disease (PD) but there is a need for a large-scale study that involves suitable population based controls.
12p vioraclene 31-03-2024 4 1 Download
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The human gut harbors trillions of microbes that play dynamic roles in health. While the microbiome contributes to many cardiometabolic traits by modulating host inflammation and metabolism, there is an incomplete understanding regarding the extent that and mechanisms by which individual microbes impact risk and development of cardiovascular disease (CVD).
16p vibransone 28-03-2024 9 2 Download
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Next-generation sequencing (NGS) based population screening holds great promise for disease prevention and earlier diagnosis, but the costs associated with screening millions of humans remain prohibitive. New methods for population genetic testing that lower the costs of NGS without compromising diagnostic power are needed.
12p vicwell 29-02-2024 5 1 Download
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Ebook "Ambient air pollution and health impact in China" focuses on the health impacts of air pollution in China, especially the epidemiology-based exposure-response functions for the mortality, morbidity, and hospital admissions for respiratory diseases, cardiovascular diseases, lung cancer, and mental health related to pollution. It also provides the latest estimates of the magnitude of the adverse effects of air pollution on the health of the Chinese population.
277p lucchinguyen 28-12-2023 7 2 Download
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Part 2 book "Disease in wild animals, investigation and management" includes content: Disease management through manipulation of the host population, disease management through treatment and immunization, disease management through environmental modification, disease management through influencing human activities, emergency and integrated management programs, assessing the effectiveness of a disease-management program.
173p oursky10 04-12-2023 8 3 Download
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Part 1 book "Genetics in medicine" includes content: Introduction, introduction to the human genome, the human genome, human genetic diversity - mutation and polymorphism, principles of clinical cytogenetics and genome analysis, the chromosomal and genomic basis of disease - disorders of the autosomes and sex chromosomes, patterns of single gene inheritance, complex inheritance of common multifactorial disorders, genetic variation in populations, identifying the genetic basis for human disease.
197p oursky09 08-11-2023 7 3 Download
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Part 2 book "Ecology of diseases transmitted by mosquitoes to wildlife" includes content: Consequences of deforestation and habitat degradation on wildlife mosquito-borne diseases, implication of human landscape transformation on mosquito populations, a meta-analytic approach to investigate mosquitoes blood feeding preferences from non-urban to urban environments, surveillance of invasive mosquito species in islands with focus on potential vectors of zoonotic diseases,... and other contents.
140p oursky08 01-11-2023 5 3 Download
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Part 1 book "Genetics and evolution of infectious diseases" includes content: Recent developments in the definition and official names of virus species; a theory based pragmatism for discovering and classifying newly divergent species of bacterial pathogens, population structure of pathogenic bacteria, epidemiology and evolution of fungal pathogens in plants and animals, clonal evolution, coevolution of host and pathogen, microbes as tracers of past human demography and migrations, phylogenetic analysis of pathogens,... and other contents.
332p oursky07 23-10-2023 6 1 Download
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Part 2 book "Advances in animal health, medicine and production - A research portrait of the centre for interdisciplinary research in animal health" includes content: The public health risk of companion animal to human transmission of antimicrobial resistance during different types of animal infection; antibacterial alternatives in the scope of one health; vectors and vector borne diseases - morphological and molecular diagnosis, risk assessment, population genetics and control strategies,... and other contents.
308p oursky06 13-10-2023 5 3 Download
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Toxoplasmosis is caused by the protozoan parasite Toxoplasma gondii (T. gondii), which is one of the most widespread zoonotic pathogens known today. It is a global health hazard as they infect 30-50% of the world’s human population.
4p viwhitewolf 03-07-2023 5 3 Download
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Previously, it was shown that the HFE gene (associated with human hereditary hemochromatosis) has several haplotypes of intronic polymorphisms. Some haplotype frequencies are race specific and hence can be used in phylogenetic analysis.
13p vinarcissa 21-03-2023 2 1 Download
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Considerable natural variation for lifespan exists within human and animal populations. Genetically dissecting this variation can elucidate the pathways and genes involved in aging, and help uncover the genetic mechanisms underlying risk for age-related diseases.
13p vinarcissa 21-03-2023 9 1 Download
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Mapping by admixture linkage disequilibrium (MALD) is a whole genome gene mapping method that uses LD from extended blocks of ancestry inherited from parental populations among admixed individuals to map associations for diseases, that vary in prevalence among human populations.
11p vinarcissa 21-03-2023 5 1 Download
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It has been well-established, both by population genetics theory and direct observation in many organisms, that increased genetic diversity provides a survival advantage. However, given the limitations of both sample size and genome-wide metrics, this hypothesis has not been comprehensively tested in human populations.
7p vinarcissa 21-03-2023 2 1 Download
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Genomic information can be used to predict not only continuous but also categorical (e.g. binomial) traits. Several traits of interest in human medicine and agriculture present a discrete distribution of phenotypes (e.g. disease status).
9p vinarcissa 21-03-2023 4 1 Download
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Demography and environmental adaptation can affect the global distribution of genetic variants and possibly the distribution of disease. Population heterozygosity of single nucleotide polymorphisms has been shown to decrease strongly with distance from Africa and this has been attributed to the effect of serial founding events during the migration of humans out of Africa.
12p vinarcissa 21-03-2023 2 2 Download
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Characterization of the biological processes shaping the genetic structure of the Italian population
The genetic structure of human populations is the outcome of the combined action of different processes such as demographic dynamics and natural selection. Several efforts toward the characterization of population genetic architectures and the identification of adaptation signatures were recently made.
11p vinarcissa 21-03-2023 2 1 Download