Human insulin
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The rising prevalence of type 2 diabetes (T2D) poses a major global challenge. It remains unresolved to what extent transcriptomic signatures of metabolic dysregulation and T2D can be observed in easily accessible tissues such as blood. Additionally, large-scale human studies are required to further our understanding of the putative inflammatory component of insulin resistance and T2D.
17p vibransone 28-03-2024 3 2 Download
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Identification of causal genes for polygenic human diseases has been extremely challenging, and our understanding of how physiological and pharmacological stimuli modulate genetic risk at disease-associated loci is limited.
16p viellison 28-03-2024 7 2 Download
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Ebook "Stem cell therapy for diabetes" provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes. Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming.
294p cotieubac1004 15-03-2024 0 0 Download
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Insulin resistance is an overlapping risk factor for both heart and breast cancer, while its interaction with cardiotoxicity in breast cancer (BC) patients is not clear. This study investigated the impact of insulin resistance on cardiac remodeling in patients with human epidermal growth factor receptor 2 (HER2)-positive BC during and after trastuzumab therapy in real-world clinical practice.
12p vioracle 29-09-2023 5 4 Download
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Insulin therapy is the primary therapy in the treatment of Type 1 Diabetes (T1D) patients. And is an additional therapy for patients with Type 2 Diabetes (T2D), which is combined with Non-insulin drugs in order to be more effective in treatment [4]. Choosing the right type of insulin for each patient plays an important role in ensuring that the treatment is highly effective, minimizing the side effects caused by the drug and bringing many economic benefits to the patients.
11p nhanchienthien 25-07-2023 9 2 Download
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Hypoglycemia is a fairly common complication in diabetic patients, particularly in those on insulin therapy. Hypoglycemia symptoms are classified into two types: Autonomic and neuroglycopenic symptoms.
6p vigamora 23-05-2023 4 2 Download
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Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-gorelated gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia.
9p vinarcissa 21-03-2023 3 1 Download
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Diabetes and obesity are multifactorial diseases caused by a complex interaction of environmental and genetic factors, with the latter consisting of multiple susceptibility genes, making it difficult to clarify their functions and interactions in conferring susceptibility to diabetes and obesity in humans.
10p vinarcissa 21-03-2023 2 1 Download
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The applicability of capillary zone electrophoresis (CZE) for the separation of the deamidated forms of insulin has been studied. 50 mM NH4Ac (pH=9) with 20 % v/v isopropylalcohol was found optimal for efficient separation of insulin from its even 10 deamidated forms.
8p viginny 23-12-2022 6 3 Download
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In this work, human insulin and its 6 analogues were separated and determined using CZE-MS. Three different capillaries (bare fused silica, successive multiple ionic-polymer layer (SMIL) and static linear polyacrylamide (LPA) coated) were compared based on their separation performances in their optimal operating conditions.
9p vironald 15-12-2022 6 2 Download
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To assess insulin resistance by HOMA-IR and serum human placental lactogen (hPL) level and the relationship between these factors and risk factors of gestational diabetes mellitus (GDM). Subjects and methods: A descriptive, cross-sectional study on 252 pregnant women with GDM and 48 pregnant women without GDM (non-GDM) from 7/2018 to 1/2022 at the National Hospital of Endocrinology.
10p viangelamerkel 18-07-2022 8 2 Download
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Long-term exposure to elevated levels of free fatty acids (FFAs) is deleterious for beta-cell function and may contribute to development of type 2 diabetes mellitus (T2DM). Whereas mechanisms of impaired glucosestimulated insulin secretion (GSIS) in FFA-treated beta-cells have been intensively studied, biological events preceding the secretory failure, when GSIS is accentuated, are poorly investigated.
11p vitzuyu2711 29-09-2021 13 1 Download
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Bone marrow mesenchymal stem cells are a potential resource for the clinical therapy of certain diseases. Canine, as a companion animal, living in the same space with human, is an ideal new model for human diseases research.
15p vilichoo2711 23-06-2021 12 1 Download
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Trong thai kỳ, bánh nhau tiết một số chất có tác dụng đề kháng insulin như hPL (human Placenta Lactogen), progesterone, prolactin, cortisol và TNF (Tumor Necrosis Factor), do đó thường kết hợp với tình trạng tăng đề kháng insulin. Vì thế, nếu các tế bào β đảo tụy của mẹ không tiết thêm đủ insulin thì mẹ sẽ bị tăng đường huyết. Bài giảng này sẽ trình bày cách theo dõi thai kỳ có đái tháo đường, mời các bạn cùng tham khảo.
2p larachdumlanat126 24-12-2020 19 2 Download
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Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growth hormone and insulin-like growth factor I (IGF-I) pathway and partially restore dysmorphogenesis in tbx5 morphants.
15p viwyoming2711 16-12-2020 13 1 Download
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Diabetes mellitus is a common metabolic disorder of carbohydrate, fat, and protein metabolism. It is characterized by increased glucose levels (hyperglycemia). Diabetes mellitus arises due to defects in insulin secretion or action, or both. Solute carrier family 30 (Zinc transporter) member 8 also known as SLC30A8 is a human gene that codes for a Zinc transporter which in turn is associated to insulin secretion in humans.
5p caygaocaolon8 07-11-2020 11 1 Download
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Genome-wide association studies have enabled identification of thousands of loci for hundreds of traits. Yet, for most human traits a substantial part of the estimated heritability is unexplained. This and recent advances in technology to produce high-dimensional data cost-effectively have led to method development beyond standard common variant analysis.
8p vioklahoma2711 19-11-2020 7 1 Download
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Advanced or metastatic renal cell carcinoma (RCC) has a poor prognosis, because it is relatively resistant to conventional chemotherapy or radiotherapy. Treatments with human interferon-α2b alone or in combination with mammalian target of rapamycin (mTOR) inhibitors have led to only a modest improvement in clinical outcome.
14p vijisoo2711 29-09-2020 6 1 Download
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There is growing evidence indicating the insulin-like growth factor 1 receptor (IGF-1R) plays a critical role in the progression of human colorectal carcinomas. IGF-1R is an attractive drug target for the treatment of colon cancer. Picropodophyllin (PPP), of the cyclolignan family, has recently been identified as an IGF-1R inhibitor.
10p vijennie2711 29-09-2020 15 1 Download
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Molecular imaging of breast cancer is a promising emerging technology, potentially able to improve clinical care. Valid imaging targets for molecular imaging tracer development are membrane-bound hypoxia-related proteins, expressed when tumor growth outpaces neo-angiogenesis.
19p vijennie2711 29-09-2020 18 1 Download