Human papillomavirus 16

Head and neck cancers, particularly oropharyngeal cancers (OPC), have been increasingly associated with human papillomavirus (HPV) infections, specifically HPV16. The current methods for HPV16 detection primarily rely on p16 staining or PCR techniques.

13p vishanshan 27-06-2024 1 1   Download

Persistent high-risk (hr) human papillomavirus (HPV) infection is a necessary cause of cervical cancer. Cervical cancer is a major public health problem in Sub-Saharan Africa including South Africa. This study investigated the prevalence of and factors associated with hr-HPV infection among women attending a tertiary hospital in Gauteng Province, South Africa.

12p vialfrednobel 23-12-2023 4 3   Download

Trong số các type HPV gây bệnh ở người, type 16 và 18 là hai type có tỷ lệ gây ung thư cổ tử cung rất cao. Các nghiên cứu cho thấy sự biến đổi trình tự nucleotide trong bộ gen của type 16, 18 có thể thúc đẩy tiến triển ung thư cổ tử cung và các triệu chứng khác ở người bệnh. Trong nghiên cứu này, phân tích sự biến đổi trình tự nucleotide trên các gen E6, E7 và L1 của hai type HPV 16 và 18 ở những người bệnh đã được xác định mắc ung thư cổ tử cung.

9p vinikolatesla 25-03-2022 22 2   Download

The purpose of this study was to investigate the global expression changes of miRNAs, lncRNAs and mRNAs driven by the E6 and E7 oncoproteins of HPV16, and construct a corresponding ceRNA regulatory network of coding and non-coding genes to suggest a regulatory network associated with high-risk HPV16 infections.

19p vimahuateng 26-11-2021 9 1   Download

Human papillomavirus (HPV) type 16 accounts for a larger share of cervical cancer and has been a major health problem worldwide for decades. The progression of initial infection to cervical cancer has been linked to viral sequence properties; however, the role of HPV16 variants in the risk of cervical carcinogenesis, especially with longitudinal follow-up, is not fully understood in China.

9p vimahuateng 26-11-2021 9 0   Download

This paper proposed two new feature extraction techniques, i.e. ChaosCentroid and ChaosFrequency, for predicting HPV genotypes associated with the cancer. The additional diversified 12 HPV genotypes, i.e. types 6, 11, 16, 18, 31, 33, 35, 45, 52, 53, 58, and 66, were studied in this paper.

13p vikentucky2711 26-11-2020 11 2   Download

High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region (LCR)of HPV16 may alter the oncogenic potential of the virus.

8p vijennie2711 29-09-2020 9 1   Download

Disruption of the transforming growth factor-beta (TGF-β) signaling pathway is observed in many cancers, including cervical cancer, resulting in TGF-β resistance. While normal human keratinocytes (HKc) and human papillomavirus type 16-immortalized HKc (HKc/HPV16) are sensitive to the growth inhibitory effects of TGF-β, HKc/HPV16 develop resistance to TGF-β1 as they progress in vitro to a differentiation resistant phenotype (HKc/DR).

12p vijennie2711 29-09-2020 16 1   Download

Human papillomaviruses (HPV) are the causative agents of cervical cancer in women, which results in over 250 000 deaths per year. Presently there are two prophylactic vaccines on the market, protecting against the two most common high-risk HPV types 16 and 18. These vaccines remain very expensive and are not generally affordable in developing countries where they are needed most.

15p virose2711 24-09-2020 9 0   Download

Persistent infection with oncogenic Human Papillomavirus (HPV) is associated with the development of cervical cancer with each genotype differing in their relative contribution to the prevalence of cervical disease. HPV DNA testing offers improved sensitivity over cytology testing alone but is accompanied by a generally low specificity.

10p virose2711 24-09-2020 9 1   Download

Analysing human papillomavirus (HPV) viral load is important in determining the risk of developing cervical cancer (CC); most knowledge to date regarding HPV viral load and cervical lesions has been related to HPV-16. This study evaluated the association between the viral load of the six most prevalent high-risk viral types in Colombia and cervical intraepithelial neoplasia (CIN) frequency.

11p vialabama2711 21-09-2020 16 0   Download

The role of human papillomavirus (HPV) in the development of esophageal cancer remains controversial. Our study aims to test the association between HPV 16 infection and esophageal cancer in China, providing useful information on this unclear association in Chinese population.

8p vialabama2711 21-09-2020 22 0   Download

The high risk Human Papillomavirus (HPV) E6 oncoproteins play an essential role in the development of cervical malignancy. Important cellular targets of E6 include p53 and the PDZ domain containing substrates such as hScrib and Dlg. We recently showed that hScrib activity was mediated in part through recruitment of protein phosphatase 1γ (PP1γ).

9p vialabama2711 21-09-2020 13 0   Download

Cervical cancer is the fourth most common type of cancer affecting women globally. In Brazil, it is the third most frequent type of cancer in women and HPV is present in approximately 90% of cases. Evidence suggests that variants of HPV 16 can interfere biologically and etiologically during the development of cervical cancer.

11p vitokyo2711 31-08-2020 19 3   Download

Alterations in the host cellular immune response allow persistent infections with High-Risk Human Papillomavirus (HR-HPV) and development of premalignant cervical lesions and cervical cancer (CC). Variations of immunosuppressive cytokine levels in cervix are associated with the natural history of CC.

14p vinaypyidaw2711 26-08-2020 8 2   Download

The aims of this study were to detect HPV E6/E7 mRNA expression in women with high-risk genotypes (HPV-16, -18, -31, -33 and -45) analysing its relationship with tissue pathology and 2) 2-year follow-up of E6/E7 mRNA tested group.

7p vimale2711 25-08-2020 11 2   Download

Human papillomavirus (HPV) 16 and 18 are the two most common HPV oncogenic types that can be prevented by vaccination. This study aimed at assessing the cost-effectiveness of 3 doses of the bivalent HPV vaccine in rural and urban settings in China.

12p vimale2711 25-08-2020 12 2   Download

Human Papillomavirus (HPV) infection is the main risk factor for the development and progression of cervical cancer. HPV-16 E6 and E7 expression is essential for induction and maintenance of the transformed phenotype.

8p vibaku2711 22-07-2020 12 2   Download

Cervical cancer prevalence is increasing every year. The major cause of this cervical cancer is the infection of high-risk Human papillomavirus (HPV) types. HPV variation is related to its ethnicity and geographical source. The objective of this study is to analyze HPV genetic diversity from the two Sumatran regions, Pekanbaru and Padang.

10p angicungduoc6 22-07-2020 6 1   Download

The new nine-valent vaccine against human papillomavirus (HPV) includes the four HPV genotypes (6, 11, 16, and 18) that are targeted by the older quadrivalent HPV vaccine, plus five additional oncogenic types (31, 33, 45, 52, and 58) remain significantly associated with high grade lesions.

9p vibaku2711 22-07-2020 14 2   Download