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Human PPI networks
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Obesity is heritable. It predisposes to many diseases. The objectives of this study were to create a compendium of genes relevant to feeding behavior (FB) and/or body weight (BW) regulation; to construct and to analyze networks formed by associations between genes/proteins; and to identify the most significant genes, biological processes/pathways, and tissues/organs involved in BW regulation.
28p
vinarcissa
21-03-2023
4
1
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As numerous experimental factors drive the acquisition, identification, and interpretation of proteinprotein interactions (PPIs), aggregated assemblies of human PPI data invariably contain experiment-dependent noise.
16p
viwyoming2711
16-12-2020
9
1
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Human T-cell leukemia viruses (HTLV) tend to induce some fatal human diseases like Adult T-cell Leukemia (ATL) by targeting human T lymphocytes. To indentify the protein-protein interactions (PPI) between HTLV viruses and Homo sapiens is one of the significant approaches to reveal the underlying mechanism of HTLV infection and host defence.
10p
vikentucky2711
26-11-2020
9
1
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Our knowledge of global protein-protein interaction (PPI) networks in complex organisms such as humans is hindered by technical limitations of current methods. Results: On the basis of short co-occurring polypeptide regions, we developed a tool called MP-PIPE capable of predicting a global human PPI network within 3 months.
22p
vikentucky2711
26-11-2020
11
1
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Recently, several studies have drawn attention to the determination of a minimum set of driver proteins that are important for the control of the underlying protein-protein interaction (PPI) networks. In general, the minimum dominating set (MDS) model is widely adopted.
13p
vikentucky2711
24-11-2020
13
1
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Discovering robust markers for cancer prognosis based on gene expression data is an important yet challenging problem in translational bioinformatics. By integrating additional information in biological pathways or a protein-protein interaction (PPI) network, we can find better biomarkers that lead to more accurate and reproducible prognostic predictions.
10p
vioklahoma2711
19-11-2020
11
0
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Community detection algorithms are fundamental tools to uncover important features in networks. There are several studies focused on social networks but only a few deal with biological networks. Directly or indirectly, most of the methods maximize modularity, a measure of the density of links within communities as compared to links between communities.
25p
vijisoo2711
27-10-2020
6
0
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To reveal pharmacological targets and molecular mechanisms of curcumol against interstitial cystitis
Interstitial cystitis, protein-protein interaction This study was designed to reveal the predictive targets and biological mechanisms of curcumol against interstitial cystitis (IC). By use of available databases and bioinformatic assays, pathogenetic targets of IC and functional targets of curcumol were identified respectively. A network of functional protein-protein interaction (PPI) was produced before screening the main predictive targets, biological processes and signaling pathways of curcumol against IC.
8p
trinhthamhodang1
14-11-2019
17
1
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