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Hydrazonoyl chlorides
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In addition, the novel bis-(1,2,4-triazole-3-thione) was reacted with the appropriate hydrazonoyl chloride in dioxane under reflux in the presence of triethylamine to give the corresponding bis-(1,2,4-triazolethiohydrazonoate). The structures of the new compounds were established based on elemental and spectral data. The mechanism of the studied reaction was also discussed.
15p
langthannam
29-12-2021
4
0
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1-(Benzothiazol-2-yl)-3-phenylthiourea 2 was prepared and treated with hydrazonoyl chlorides 3a–e to yield the corresponding 5-(benzothiazol-2-ylimino)-1,3,4-thiadiazole derivatives 6a–e, respectively. Reaction of the thiourea derivative 2 with ethyl 2-chloro-3-oxobutanoate 9 afforded the corresponding 2-(benzothiazol-2-ylimino)thiazole5-carboxylate derivative 11. The newly synthesized heterocyclic derivatives were confirmed from their elemental and spectral analyses.
6p
langthannam
29-12-2021
5
0
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Many heterocyclic compounds containing thiazole or 1,3,4-thiadiazole ring in their skeletons have been reported to possess various pharmacological activities especially anticancer activities.
8p
vijiraiya2711
27-05-2020
10
1
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An efficient and a novel approach for the synthesis of some novel pyrazole based-azoles are described via multi-component reaction under controlled microwave heating conditions.
12p
vijiraiya2711
27-05-2020
17
1
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A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety
Thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities. A novel series of thiazoles carrying 1,3,4-thiadiazole core were designed and prepared via the reaction of the 2-(4-methyl-2-phenylthiazole-5-carbonyl)-N-phenylhydrazinecarbo-thioamide with the appropriate hydrazonoyl chlorides. T
9p
vijiraiya2711
27-05-2020
8
0
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Starting from N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides, a series of new functionalized 1,3,4-thiadiazoles were prepared. The structures of the compounds prepared were confirmed by both elemental and spectral analyses as well as by alternate synthesis. The mechanisms of the studied reactions are outlined. The antimicrobial activities of the compounds prepared were screened and the results showed that most of such compounds exhibit considerable activities.
9p
trinhthamhodang1
16-11-2019
11
0
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