Hyperchloremic metabolic acidosis

Compare the efficacy and safety of Plasma-Lyte A (PLA) versus 0.9 % sodium chloride (NaCl) intravenous (IV) fluid replacement in children with moderate to severe dehydration secondary to acute gastroenteritis (AGE).

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(BQ) Continued part 1, part 2 of the document Clinical evaluation and management in fluid, electrolyte and acid base disorders has contents: Disorders of magnesium, disorders of phosphate, disorders of phosphate, evaluation of an acid–base disorder, high anion gap metabolic acidosis, hyperchloremic metabolic acidosis,... and other contents. Invite you to refer.

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Approach to the Patient: Hyperchloremic Metabolic Acidoses In diarrhea, stools contain a higher [HCO3–] and decomposed HCO3– than plasma so that metabolic acidosis develops along with volume depletion. Instead of an acid urine pH (as anticipated with systemic acidosis), urine pH is usually around 6 because metabolic acidosis and hypokalemia increase renal synthesis and excretion of NH4+, thus providing a urinary buffer that increases urine pH. Metabolic acidosis due to gastrointestinal losses with a high urine pH can be differentiated from RTA (Chap.

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