IFN-γ release assay

One forth whole-world population is infected with Mycobacterium tuberculosis (Mtb), but 90% of them are asymptotic latent infection without any symptoms but positive result in IFN-γ release assay. There is lack of ideal strategy to distinguish active tuberculosis (TB) and latent tuberculosis infection (LTBI).

12p vimichigan2711 26-03-2021 6 1   Download

The present study aimed at evaluating the BCG vaccine immunogenicity testing in young sahiwal calves. The bTB screening and vaccine immunogenicity were evaluated using the OIE approved Interferon gamma release assay (IGRA) using BOVIGAM™ kit. BCG was titrated with 105 colony forming units (CFU) and observed from the present study that low dose of 105 (CFU) is found to be effective for inducing significant bTB specific protective IFN-gamma at day 14 post vaccination.

6p angicungduoc5 12-06-2020 16 3   Download