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IFN response
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As an essential regulator of type I interferon (IFN) response, TMEM173 participates in immune regulation and cell death induction. In recent studies, activation of TMEM173 has been regarded as a promising strategy for cancer immunotherapy. However, transcriptomic features of TMEM173 in B-cell acute lymphoblastic leukemia (B-ALL) remain elusive.
14p
vischultz
20-10-2023
4
1
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Bovine parainfluenza virus type 3 (BPIV3) is one of the important viral respiratory agents associated with the bovine respiratory disease complex (BRDC) in cattle. Previous study has demonstrated that infection of BPIV3 causes innate immune response within the host cell.
10p
vigalileogalilei
28-02-2022
9
1
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Interferon regulatory factor 2 (IRF2) is an important transcription factor, which can regulate the IFN response and plays a role in antiviral innate immunity in teleost. In the present study, the full-length cDNA sequence of IRF2 (CcIRF2) was characterized in common carp (Cyprinus carpio L.).
12p
vidarwin
23-02-2022
9
1
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Interferon (IFN) regulatory factors (IRFs), as transcriptional regulatory factors, play important roles in regulating the expression of type I IFN and IFN- stimulated genes (ISGs) in innate immune responses. In addition, they participate in cell growth and development and regulate oncogenesis.
11p
vidarwin
23-02-2022
12
1
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The type I interferon (IFN) response is an ancient pathway that protects cells against viral pathogens by inducing the transcription of hundreds of IFNstimulated genes. Comprehensive catalogs of IFN-stimulated genes have been established across species and cell types by transcriptomic and biochemical approaches, but their antiviral mechanisms remain incompletely characterized.
36p
viarchimedes
26-01-2022
10
0
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Accompanied with rapid growth and high density aquaculture, gibel carp has been seriously threatened by Carassius auratus herpesvirus (CaHV) since 2012. In previous study, distinct CaHV resistances and immune responses were revealed in the diseased individuals of three gibel carp gynogenetic clones (A+ , F and H).
19p
visilicon2711
20-08-2021
8
1
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For nearly two decades now, various studies have reported detecting the Epstein-Barr virus (EBV) in breast cancer (BC) cases. Yet the results are unconvincing, and their interpretation has remained a matter of debate. We have now presented prospective data on the effect of EBV infection combined with survival in patients enrolled in a prospective study.
11p
vilisa271
22-09-2020
9
0
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Renal cell carcinoma (RCC) is a tumor with immunogenic properties. Soluble interleukin-2 receptor (sIL-2R) has a role in T cell activation and may be important for immune regulation in various conditions, including infections, transplantation rejection, autoimmune inflammatory states, and cancer.
10p
vidhaka2711
31-07-2020
10
1
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We recently reported that STAT1 plays a tumor suppressor role, and ERK was inversely correlation with STAT1 expression in esophageal squamous cell carcinoma (ESCC). Here, we investigated the mechanism(s) that are responsible for the ERK regulates STAT1 in ESCC.
10p
vibaku2711
22-07-2020
15
2
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Pancreatic cancer is characterized by a highly immunosuppressive tumor microenvironment and evasion of immune surveillance. Although programmed cell death 1 receptor (PD-1) blockade has achieved certain success in immunogenic cancers, the responses to the PD-1 antibody are not effective or sustained in patients with pancreatic cancer.
11p
vikuala271
13-06-2020
8
0
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Interferon-gamma (IFN-γ) is an important mediator of type I immune response and has antiviral, immunoregulatory and anti-tumor properties, plays a wide range of roles in inflammation and autoimmune diseases.
7p
vihamax2711
21-04-2020
13
1
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In the present study, we developed a killed and LPS based Brucella suis vaccine and evaluated the humoral and cell mediated immune response in mice. Brucella suis isolated from field and developed as vaccine. Lipopolysaccharides from B. suis were administered to the nude mice, in addition to killed vaccine from that species whereas mineral oil was used as an adjuvant. The vaccines from B. suis is considered as smooth strain with smooth dissociation.
9p
nguathienthan2
19-12-2019
5
1
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To investigate whether mTOR signaling pathway regulate the proliferation and differentiation of CD8+ T cells by transcription factors T-bet and Eomes, and explore the role of IL-12 in this biological procedure.
7p
vicaracas2711
27-11-2019
8
0
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To determine whether the soluble programmed cell death ligand 1 (sPD-L1) levels in patients with chronic hepatitis C (CHC) are associated with the clinical features of the disease and the efficacy of treatment, including interferon (IFN)-α.
9p
vilusaka2711
19-11-2019
11
1
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Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. Currently, combined pegylated interferon and ribavirin therapy are the standard treatment. The biological activity of interferon (IFN) is mediated by the induction of intracellular antiviral proteins, such as 20 –50 oligoadenylate synthetase, and dsRNA-activated protein kinase. IFN-inducible doublestranded RNA-activated protein kinase (PKR) is thought to play a key antiviral role against HCV. Some studies observed that PKR expression was higher in sustained viral responders compared with the non-responders.
7p
kethamoi1
17-11-2019
14
1
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Autophagy plays a critical role in the regulation of innate and adaptive immune responses to pathogens and tumors. A previous study utilized proteasome and lysosome inhibitors to form autophagosomes (DRibbles) and the effect of dendritic cells (DCs) loaded with DRibbles in activating antigen-specific T cells has been demonstrated in a mouse experiment and human IL-4-DC.
10p
vinasaki2711
12-11-2019
11
0
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Hepatitis C virus (HCV) infection has long been treated with interferon therapy (IFN). Currently, more than 90% of IFN-treated patients show a sustained virological response (SVR) when also treated with ribavirin and/or a protease inhibitor. Histological inflammation and fibrosis improve in IFN-treated patients, which indicates HCV clearance
9p
vinasaki2711
12-11-2019
12
1
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Production of nitric oxide (NO) in response to bacterial lipopolysaccharide (LPS) was investigated using cultures of mouse peritoneal exudate cells (PEC) and the macrophage cell line RAW264.7. In the presence of anti-(interferon-c) (IFN-c), NO production was markedly suppressed in the PEC culture but not in the RAW264.7 culture. In the PEC culture, LPS induced both IFN-cproduction and activation of IFNresponse factor-1, which leads to the gene expression of inducible NO synthase, but neither was induced in the culture of RAW264.7 cells....
10p
tumor12
20-04-2013
27
3
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Mononuclear phagocytes play a pivotal role in the pro-gression of septic shock by producing tumor necrosis factor-a(TNF-a) andother inflammatorymediators in response to lipopolysaccharide (LPS) fromGram-negativebacteria.Our previous studies have shown monocyte and macrophage activationcorrelatewithchanges inmembranephospholipid composition, mediated by acyltransferases. Interferon-c (IFN-c), which activates and primes these cells for enhanced inflammatory responses to LPS, was found to selectively activate lysophosphatidylcholine acyltransferase (LPCAT) (P...
7p
fptmusic
16-04-2013
35
1
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The innate antiviral response requires the induction of genes and proteins with activities that limit virus replication. Among these, the well-character-ized interferon b (IFNB) gene is regulated through the cooperation of AP-1, NF-jB and interferon regulatory factor 3 (IRF-3) transcription fac-tors. Using a constitutively active form of IRF-3, IRF-3 5D, we showed previously that IRF-3 also regulates an IFN-independent antiviral response through the direct induction of IFN-stimulated genes.
12p
fptmusic
11-04-2013
28
1
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