Immune infltration
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The involvement of centromere protein M (CENPM) in various types of cancer has been established, however, its impact on breast cancer and immune infltration remains unknown. We examined the expression of CENPM in diferent cancer types by utilizing the Cancer Genome Atlas (TCGA) and Genotype Tissue Expression Pan-Cancer (GEO) databases.
19p vishanshan 27-06-2024 1 1 Download
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NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types.
22p vikoch 27-06-2024 3 1 Download
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Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored.
18p vicwell 29-02-2024 4 1 Download
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Cancer-testis antigens (CTAs) have emerged as potential clinical biomarkers targeting immunotherapy. KK-LC-1 is a member of CTAs, which has been demonstrated in a variety of tumors tissues and been found to elicit immune responses in cancer patients.
11p vimichaelfaraday 28-12-2023 3 3 Download
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Hepatocellular carcinoma (HCC) is one of the most lethal cancers, with a poor prognosis. Prognostic biomarkers for HCC patients are urgently needed. We aimed to establish a nomogram prediction system that combines a gene signature to predict HCC prognosis
16p vimichaelfaraday 28-12-2023 6 3 Download
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Previous assessments of peritumoral infammatory infltrate in colorectal cancer (CRC) have focused on the role of CD8+ T lymphocytes. We sought to compare the prognostic value of CD8 with downstream indicators of active immune cell function, specifically granzyme B (GZMB) and CD68 in the tumour microenvironment.
13p vialfrednobel 23-12-2023 4 3 Download
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Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by challenging early diagnosis and poor prognosis. It is believed that coagulation has an impact on the tumor microenvironment of PDAC. The aim of this study is to further distinguish coagulation-related genes and investigate immune infltration in PDAC.
15p vioracle 29-09-2023 6 2 Download
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V domain Immunoglobulin suppressor of T cell activation (VISTA) has been proved to be a novel immune checkpoint molecule that positively regulates T cell infltration in several malignancies. However, the clinical impact of VISTA on muscle-invasive bladder cancer (MIBC) patients remains relatively obscure.
11p vioracle 29-09-2023 7 3 Download
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Lung cancer is reported to be the leading cause of death in males and females, globally. Increasing evidence highlights the paramount importance of Lactate dehydrogenase D (LDHD) in different types of cancers, though it’s role in lung adenocarcinoma (LUAD) is still inadequately explored. In this study, we aimed to investigate and determine the relationship between LDHD and LUAD.
21p vioracle 29-09-2023 5 3 Download
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Low grade glioma (LGG) is considered a heterogeneous tumor with highly variable survival and limited efficacy of immunotherapy. To identify high-risk subsets and apply immunotherapy effectively in LGG, the status and function of immune infltration in the glioma microenvironment must be explored.
18p vioracle 29-09-2023 6 3 Download
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The centromere protein O (CENPO) is an important member of the centromere protein family. However, the role of CENPO in pan–cancer and immune infltration has not been reported. Here, we investigated the role of CENPO in pan–cancer and further validated its role in lung adenocarcinoma (LUAD) by in vitro experiments.
15p vioracle 29-09-2023 6 2 Download
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A number of human diseases have been associated with Centromere protein N (CENPN), but its role in breast cancer is unclear. Methods A pan-cancer database of Genotype Tissue Expression (GTEx) and the Cancer Genome Atlas (TCGA) were used to examine the expression of CENPN.
17p vioracle 29-09-2023 6 3 Download
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Emerging evidence has proven the robust role of tumor mutation burden (TMB) and immune cell infltration (ICI) in cancer immunotherapy. However, the precise efect of TMB and ICI on clear cell renal cell carcinoma (ccRCC) remains elusive and merits further investigation.
14p vihagrid 30-01-2023 12 3 Download
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Follicular thyroid carcinoma (FTC) is the second most common cancer of the thyroid and easily develops into distant metastasis. PD-L1 is known to be associated with the carcinogenesis and progression of thyroid carcinoma.
15p vikolindagrabar 27-07-2022 4 2 Download
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This study was conducted to evaluate the prognostic significance of different molecular typing methods and immune status based on RNA sequencing (RNA-seq) in hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative (HR+/HER2-) early-stage breast cancer and develop a modified immunohistochemistry (IHC)-based surrogate for intrinsic subtype analysis.
17p vikolindagrabar 27-07-2022 8 2 Download
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There is a paucity of data regarding the prognostic influence of peripheral blood CD4+ T lymphopenia in non-small cell lung cancer (NSCLC). Therefore, we investigated the prognostic value of T lymphopenia in NSCLC.
11p vikolindagrabar 27-07-2022 3 1 Download
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An imbalance of intra cellular iron metabolism can lead to the occurrence of ferroptosis. Ferroptosis can be a factor in the remodeling of the immune microenvironment and can affect the efficacy of cancer immuno‑ therapy. How to combine ferroptosis-promoting modalities with immunotherapy to suppress triple-negative breast cancer (TNBC) has become an issue of great interest in cancer therapy.
13p visusanwojcicki 28-06-2022 10 3 Download
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There are different subsets of T regulatory cells (Tregs), orchestrating critical roles in the regulation of anti-tumor immunity in colorectal cancer (CRC). In this study, we report that a high frequency of circulating CD4+FoxP3+ Tregs was associated with poorer disease-free survival (DFS), while their higher frequencies in tumour-infltrating CD4+ Tregs was associated with better DFS.
13p visusanwojcicki 28-06-2022 7 2 Download
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The multidisciplinary treatment including induction chemotherapy plus conversion surgery (CS) has attracted attention as a new strategy to improve the outcome of metastatic gastric cancer (MGC). However, it is unclear which patients achieve a good response to chemotherapy and successful CS.
11p visusanwojcicki 28-06-2022 8 2 Download
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The expression and activation of eukaryotic translation initiation factor 4E (eIF4E) is associated with cell transformation and tumor initiation, but the functional role and the mechanism whereby it drives immune cell infltration in breast cancer (BRCA) remain uncertain.
20p vielonmusk 21-01-2022 10 0 Download