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Immune responses against tumors
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Although HPV prophylactic vaccines can provide effective immune protection against high-risk HPV infection, studies have shown that the protective effect provided by them would decrease with the increased age of vaccination, and they are not recommended for those who are not in the appropriate age range for vaccination.
11p
vikoch
27-06-2024
1
1
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Immune checkpoint blockade (ICB) therapies, which potentiate the body’s natural immune response against tumor cells, have shown immense promise in the treatment of various cancers. Currently, tumor mutational burden (TMB) and programmed death ligand 1 (PD-L1) expression are the primary biomarkers evaluated for clinical management of cancer patients across histologies.
18p
vibransone
28-03-2024
6
1
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Immune checkpoint blockade (ICB) with antibodies inhibiting cytotoxic T lymphocyte-associated protein-4 (CTLA-4) and programmed cell death protein-1 (PD-1) (or its ligand (PD-L1)) can stimulate immune responses against cancer and have revolutionized the treatment of tumors.
13p
vibransone
28-03-2024
8
2
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Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block immune inhibitory pathways. Administration of ICIs augments T cell-mediated immune responses against tumor, resulting in improved overall survival in cancer patients. It has emerged that the intestinal microbiome can modulate responses to ICIs via the host immune system and that the use of antibiotics can lead to reduced efficacy of ICIs.
11p
vibransone
28-03-2024
4
2
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A more effective immune response against glioblastoma is needed in order to achieve better tumor control. Radiotherapy can induce anti-tumor mediated immune reactions, in addition to its dose response effects. The complement system can function as a bridge between innate and adaptive immune responses. Combining radiotherapy and complement-activating therapy is theoretically interesting.
13p
vischultz
20-10-2023
10
1
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SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch repair (MMR) in neoplastic cells. However, it remains unclear whether SETD2 dysfunction is a complementary or independent factor to microsatellite instability-high (MSI-H) and tumor mutational burden-high (TMB-H) for immunocheckpoint inhibitor (ICI) treatment, and little is known regarding whether this type of dysfunction acts differently in various types of cancer.
12p
vioracle
29-09-2023
6
2
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CD40 is an important tumor necrosis factor receptor (TNFR) family protein for the development of antitumor response against cancer cells, apart from its role in the regulation of the immune system as a costimulatory molecule. It is broadly expressed on the surface of immune cells and in diverse cancer types, including breast cancer. Here, we analyzed both CD40/CD40 ligand expression in breast cancer cells and tissues using public data sets and overall survival analysis in ungrouped breast cancer patients, as well as in the triple-negative breast cancer subtype.
9p
thiencuuchu
27-11-2021
13
1
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Tumors with deficient homologous repair are sensitive to PARP inhibitors such as olaparib which is known to have immunogenic properties. Durvalumab (D) is a human monoclonal antibody (mAb) which inhibits binding of programmed cell death ligand 1 (PD-L1) to its receptor. Tremelimumab (T) is a mAb directed against the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).
10p
vimale2711
21-08-2020
15
2
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Cancer immunotherapy is a type of therapy that uses the body's immune system to prevent, control, and eliminate cancers. The cancer cells on their surface often express the tumor antigens, which are targeted by the immune response components. The past decade has witnessed immunotherapy as an appealing and attractive strategy that established a strong pillar to fight various types of malignancies (Subramaniam et al., 2016). The therapeutic and prophylactic approaches of cancer immunotherapies have been tried against different types of cancers both in human and Veterinary medicine.
14p
angicungduoc6
22-07-2020
10
1
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Application of dendritic cells (DC) for cancer immunotherapy involves tumor-associated immunogenic antigens for effective therapeutic strategies. The present study investigated whether DC co-cultured with autologous cytokine-induced killer cells (CIK) could induce a more specific immune response against liver cancer stem cells (LCSC) generated from human hepatocellular carcinoma (HCC) cells in vitro and in vivo.
10p
vimanila2711
25-06-2020
14
1
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Human immunological memory is a hallmark of the adaptive immune system and plays an important role in the development of effective immune responses against tumors. In the present study, we aimed to determine the frequencies of CD8+ memory T cell subsets including T stem cell memory (TSCM) in tumor-draining lymph nodes of patients with breast cancer (BC).
9p
vijakarta2711
09-06-2020
17
1
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Interferon-gamma (IFN-γ) is an important mediator of type I immune response and has antiviral, immunoregulatory and anti-tumor properties, plays a wide range of roles in inflammation and autoimmune diseases.
7p
vihamax2711
21-04-2020
13
1
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Undesirable and desirable effects of stressors on the body are assigned to distress and eustress, respectively. Immune system and brain are the most susceptible parts to stressful conditions, whereas longlasting alterations in putative immune proteins involved in tension such as corticosterone (CORT), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-a) can impact learning and memory. Intermittent fasting (IF) is a repeated regular cycle of dietary restriction with well-known beneficial properties on the body.
5p
trinhthamhodang1
14-11-2019
31
2
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It is time to shift the arachidonic acid (ARA) paradigm from a harm-generating molecule to its status of polyunsaturated fatty acid essential for normal health. ARA is an integral constituent of biological cell membrane, conferring it with fluidity and flexibility, so necessary for the function of all cells, especially in nervous system, skeletal muscle, and immune system. Arachidonic acid is obtained from food or by desaturation and chain elongation of the plant-rich essential fatty acid, linoleic acid.
9p
trinhthamhodang1
14-11-2019
22
0
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Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) that affect prime naive T cells and create proper immune responses. The uncontrolled growth of cancer cells often results from the cell’s successful inhibition of cytotoxic T lymphocytes. In addition to conventional cancer treatments, including surgery, chemotherapy, and radiation therapy, immunotherapies have been seen to offer promising and innovative cancer treatments. Currently, DC therapy is one of the most popular immunotherapies because it uses tumour antigen-pulsed DC vaccines to fight against cancers.
5p
caygaocaolon1
13-11-2019
10
0
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(BQ) Continued part 1, part 2 of the document Basic immunology functions and disorders of the immune system presents the following contents: Effector mechanisms of humoral immunity, immunological tolerance and autoimmunity, immune responses against tumors and transplants, hypersensitivity, congenital and acquired immunodeficiencies.
180p
thangnamvoiva3
01-07-2016
59
5
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Malaria vaccine discovery and development follow two principal strategies. Most subunit vaccines are designed to mimic naturally acquired immunity that develops over years upon continuous exposure to Plasmodiumtrans-mission. Experimental model vaccines, such as attenuated live parasites and transmission-blocking antigens, induce immune responses superior to naturally acquired immunity.
8p
media19
04-03-2013
38
1
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Immunotherapy, based on mAbs specifically directed against cancer cells, is considered a precious strategy in the fight against cancer because of its selec-tivity and lack of multidrug resistant effects. However, there are obstacles to the complete success of current immunotherapy such as immune responses to nonhuman or even humanized antibodies and the large size of the anti-bodies, which hinders their diffusion into bulky tumors.
9p
vinaphone15
27-02-2013
31
2
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The complexes formed by partially folded human and bovine a-lactalbumin with oleic acid (OA) have been reported to display selective apoptotic activity against tumor cells. These complexes were named human (HAMLET) or bovine (BAMLET) alpha-lactalbumin made lethal to tumor cells.
15p
mobifone23
18-01-2013
45
4
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Even though human oncogenic viruses belong to different virus families and utilize diverse strategies to contribute to cancer development, they share many common features. One key feature is their ability to infect, but not kill, their host cell. In contrast to many other viruses that cause disease, oncogenic viruses have the tendency to establish long-term persistent in- fections. Consequently, they have evolved strategies for evading the host immune response, which would otherwise clear the virus during these persistent infections.
28p
taisaokhongthedung
09-01-2013
64
3
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