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In vitro activities
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This volume provides current methods to analyze the properties of designer receptors exclusively activated by designer drugs (DREADDs) in vitro and to measure the biological responses of DREADD activation in different neuronal populations in vivo. Chapters focus on the utility of DREADD technology to selectively stimulate or inhibit neuronal activity in selected brain areas of transgenic mice.
175p
vimeyers
29-05-2024
3
2
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This study is the first report on antioxidant activities and chemical composition of S. cambodianum Baill. ethanolic leaf extract. The results showed that ethanolic extract had potent in vitro antioxidant activities in DPPH, ABTS•+ assays (the low concentrations of IC50 were 19.51 ± 0.78 μg/mL and 4.89 ± 0.07 μg/mL, respectively), and in RP, TAC methods (the Abs0.5 were 20.80 ± 0.26 μg/mL and 36.15 ± 1.03 μg/mL).
7p
dianmotminh02
03-05-2024
5
1
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Cancer is the most destructive and fatal disease, representing an urgent medical challenge to the world. The discovery of a new anticancer candidate may help reduce or eliminate this alarming disease to a greater extent. On similar lines, in silico research was carried out on novel naphthylidene isoxazolidinedione derivatives that were logically conceived, synthesized, purified, and structurally characterized. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells.
10p
dianmotminh02
03-05-2024
4
1
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A series of chalcone analogues were synthesized using Claisen-Schmidt condensation and assayed for in vitro inhibitory activity against α-glucosidase. The synthesis involved in solvent-free reaction conditions including NaOHcatalyzed grinding or microwave irradiation in the presence of a clay-based catalyst. Hydroxychalcones and 2′-hydroxychalcones were not isolated when using grinding method, while the microwave-assisted, clay-catalyzed synthesis gave these desired products. In addition, flavanones, cyclization products from 2′-hydroxychalcones were formed in both methods.
8p
dianmotminh02
03-05-2024
5
1
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The melting points of the complexes were >350oC, indicating high thermal stability. Cu-Zn-containing complex showed the least binding energy against the three proteins. The bioactivity scores of the complexes were between -0.50 and 0.0. Against A549 Cu-Zn, Co-Zn and Fe-Zn containing complexes showed potential activity. Against MCF-7, Fe-Cu containing complex had IC50 of 53.5 whereas Co-Zn containing complex was active against HepG2. Three complexes were active against S. aureus in the tested range.
18p
dianmotminh02
03-05-2024
2
1
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. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively.
10p
dianmotminh02
03-05-2024
2
2
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Ebook "Small molecule therapeutics for schizophrenia" covers all relevant aspects of drug research, e.g.
327p
tracanhphuonghoa1007
22-04-2024
3
3
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Hypericum sampsonii or Sampson’s St John’s Wort is a species of flowering plant in the Hypericaceae family. Our previous study revealed the diverse and bioactive chemical constituents of the plant. This study investigates the antioxidant activity and potential hepatoprotective of Hypericum sampsonii extract (BLD1 extract) in vitro and in vivo.
7p
vilarry
12-03-2024
8
1
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Ebook "Tactics in contemporary drug design" covers all relevant aspects of drug research, e.g.
400p
manmanthanhla0201
26-02-2024
2
1
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Ebook "Analytics of Protein–DNA interactions (Advances in biochemical engineering/biotechnology, Volume 104)" focuses on the fascinating possibilities that emerged during the last years to study protein–DNA interactions in vitro. As an essential part of transcriptional activity during development and in tumorgenesis a separate chapter describing the analysis of DNA modification especially methylation of cytosines at their carbon-5 position was included.
212p
manmanthanhla0201
27-02-2024
4
2
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Ebook "The blood brain barrier (BBB)" covers all relevant aspects of drug research, e.g.
169p
nhanphanguyet
28-01-2024
5
2
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Part 2 book "Applied veterinary andrology and frozen semen technology" includes content: Gross evaluation of semen; microscopic test for evaluation of semen; sperm morphology; in vitro fertility tests; assessment of metabolic activity of semen; miscellaneous tests for evaluation of semen quality; estimation of bacterial load in semen samples;... and other contents.
129p
muasambanhan05
22-01-2024
5
2
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The aim of this study is to assess how different extraction temperatures affect the in vitro antioxidant potential of polysaccharides derived from the leaves of Myxopyrum smilacifolium.
5p
viplato
02-01-2024
7
2
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Ebook "Hepatitis B virus: Methods and protocols" details protocols and techniques ranging from cell culture studies to in vivo and clinical immunology. The chapters in this book discuss treatments of in vitro infection systems, analysis and quantification of cccDNA and its mutations; in vitro polymerase activity assays; cellular trafficking of core proteins; intracellular calcium metabolism; detection, cloning, and sequencing of HBV markers; and new strategies aimed at exploiting new mechanisms for drug discovery.
301p
lucchinguyen
28-12-2023
5
2
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Anti-inflammatory is the property of a substance or treatment that reduces inflammation in the body (redness, swelling, and pain) by blocking certain substances in the body that cause inflammation. They are used to treat many different conditions.
5p
vimichaelfaraday
28-12-2023
4
3
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Ebook "Glucose transport: Methods and protocols" explores methods used to examine the structure-function relationship of glucose transporters both in vitro and ex vivo.
270p
lucchinguyen
28-12-2023
3
2
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Ebook "DNA topoisomerases: Methods and protocols"cover various topics, such as type 1 topos with an evolutionary perspective; antimicrobial agents targeting topos; experimental protocols related to DNA topology, including a basic technique to measure DNA supercoiling in bacteria; protocols for in vitro studies, including assays to detect RNA topo activity; topo inhibitors; and a study of plasmid-mediated quinolone resistance in bacteria.
328p
lucchinguyen
28-12-2023
4
2
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Part 1 book "Reproductive technologies in farm animals" includes content: Introduction, artificial insemination, embryo transfer, in vitro embryo production, controlling oestrus and ovulation, control of postpartum ovarian activity.
195p
muasambanhan02
25-12-2023
5
2
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The flowers of Hylocereus undatus (Haw.) Britton & Rose have been reported in vitro antioxidant and tyrosinase inhibitory activities. This study screened preliminarily the triterpenoid constituents and evaluated in vitro tyrosinase inhibitory activity of H. undatus flowers. H. undatus flowers were harvested from Binh Thuan Province, Vietnam at four different flowering stages, and their five separated parts (stamen, pistil, petals, ovary, and sepals) were extracted with ethanol.
7p
vikissinger
21-12-2023
3
1
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Achyranthes bidentata Blume is a precious herb. In the chemical composition of its root, saponin is the main compound that when being hydrolyzed form oleanolic acid - an active ingredient in liver cell protection, anti-tumor and antiviral agent, anti-HIV and HCV in vitro.
5p
vialfrednobel
21-12-2023
4
2
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