Including target therapy
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In neuro-oncology, the inclusion of tumor patients in the molecular tumor board has only become increasingly widespread in recent years, but so far there are no standards for indication, procedure, evaluation, therapy recommendations and therapy implementation of neuro-oncological patients. The present work examines the current handling of neuro-oncological patients included in molecular tumor boards in Germany.
9p vikoch 27-06-2024 1 1 Download
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Ebook "Mitochondria and cancer" presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins.
294p ladongphongthanh1008 22-04-2024 3 1 Download
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Ebook "Targeted therapies in cancer: Myth or Reality?" contributes to improve our approach to cancer drug discovery and, ultimately, to find new, more efficacious and better tolerated drugs for cancer patients. It provides an overview of diverse approaches ranging from drug discovery to cellular therapy. Although this change in paradigm has been useful, its entry into the clinical arena was associates with unforeseen problems including the emergence of resistance, unexpected side effects and failures.
200p ladongphongthanh1008 22-04-2024 7 1 Download
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In high-grade serous ovarian cancer (HGSOC), intrinsic and/or acquired resistance against platinumcontaining chemotherapy is a major obstacle for successful treatment. A low frequency of somatic mutations but frequent epigenetic alterations, including DNA methylation in HGSOC tumors, presents the cancer epigenome as a relevant target for innovative therapy.
15p vioraclene 31-03-2024 4 2 Download
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Ebook "Impact of genetic targets on cancer therapy" provides a forum for original peer-reviewed short communications, full-length research and review articles on new research findings and developments on the topic of genetic targets on cancer therapies. As the field is highly important it requires co-operation between research communities from all over the world to share their knowledge and experience in order to move the field forward.
447p cotieubac1004 15-03-2024 2 0 Download
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Ebook "Bioactive sphingolipids in cancer biology and therapy" presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics.
491p cotieubac1004 15-03-2024 2 0 Download
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Part 2 book "Cancer immunology and immunotherapy" includes content: Adoptive cellular therapy, dendritic cell subsets as vectors and targets for improved cancer therapy, identification of human idiotype specific T-cells in lymphoma and myeloma, immunologically active biomaterials for cancer therapy,... and other contents.
156p muasambanhan08 23-02-2024 10 1 Download
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Cancer therapy has evolved from non-specific cytotoxic agents to a selective, mechanism-based approach that includes targeted agents and immunotherapy. Although the response to targeted therapies for unresectable hepatocellular carcinoma (HCC) is acceptable with the improved survival, the high tumor recurrence rate and drug-related side effects continue to be problematic.
8p vileonardodavinci 23-12-2023 9 4 Download
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Part 2 book "Handbook of small animal imaging - Preclinical imaging, therapy, and applications" includes content: Radiochemistry for preclinical imaging studies, molecular targets and optical probes, developing technologies for small animal radiotherapy, quantification in nuclear preclinical imaging,.... and other contents.
342p oursky08 04-11-2023 6 3 Download
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As the dominant component of the tumor microenvironment, cancer-associated fibroblasts (CAFs), play a vital role in tumor progression. An increasing number of studies have confirmed that CAFs are involved in almost every aspect of tumors including tumorigenesis, metabolism, invasion, metastasis and drug resistance, and CAFs provide an attractive therapeutic target.
15p vischultz 20-10-2023 5 2 Download
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Lymph node (LN) metastasis is the earliest sign of metastatic spread and an established predictor of poor outcome in gallbladder cancer (GBC). Patients with LN positive GBC have a significantly worse survival (median survival- 7 months) than patients with LN negative disease (median survival-~23 months) in spite of standard treatment which includes extended surgery followed by chemotherapy, radiotherapy and targeted therapy.
15p visharma 20-10-2023 4 2 Download
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Targeting the immune checkpoint of programmed death ligand 1 (PDL1) and programmed cell death protein 1 (PD-1) with immunotherapy has improved the treatment of many tumors including non-small cell lung cancer (NSCLC). Checking PD-L1 status must be done during the course of therapy.
4p viintuit 26-09-2023 0 0 Download
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Part 1 book "Ectoparasites drug discovery against moving targets" includes content: Comparison of anti‐ectoparasite and anti‐endoparasite therapies and control strategies, vaccination against ticks, blocking transmission of vector‐borne diseases, the threat and reality of drug resistance in the cattle tick rhipicephalus (boophilus) microplus, monitoring drug sensitivity in cattle ticks, new developments in the control of human lice.
150p oursky04 14-09-2023 7 2 Download
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Part 1 of ebook "Veterinary laser therapy in small animal practice (First edition)" provides readers with content including: light’s actions in the body; light is just the catalyst; blood and light; anti-inflammatory effect; analgesic effect; tissue healing; pointing the light into the patient; light’s path to all these places in the body; pointing light at soft tissue: clinical applications; different flavors (frequencies) for different tissues;...
171p lytamnguyet 04-08-2023 5 2 Download
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Several studies have demonstrated the antitumor activity of rosiglitazone (RGZ) in cancer cells, including breast cancer cells. However, the molecular targets of RGZ in the inhibition of angiogenesis in breast cancer cells remain unclear.
17p vihagrid 30-01-2023 5 3 Download
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This includes group-based support delivered by trained lay local community facilitators (CFs) and free nicotine replacement therapy (NRT). The intervention was pilot tested in a cluster randomised controlled trial, ‘We Can Quit 2’. This paper reports on the WCQ2 process evaluation which assessed feasibility and acceptability of the programme and trial processes.
14p viferrari 28-11-2022 7 2 Download
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We aimed to investigate response and prognostic factors in patients with human epidermal growth factor receptor 2 (HER2) positive metastatic colorectal cancer (mCRC) and compare the curative effects on patients who received different therapy regimens (including chemotherapy and chemotherapy combined with targeted drugs).
9p viangelamerkel 27-07-2022 3 1 Download
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Optimizing cardiac stroke volume during major surgery is of interest to many as a therapeutic target to decrease the incidence of postoperative complications. Because dynamic preload indicators are strongly correlated with stroke volume, it is suggested that these indices can be used for goal directed fluid therapy. However, threshold values of these indicators depend on many factors that are influenced by surgery, including opening of the abdomen.
5p viisaacnewton 26-04-2022 10 1 Download
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Pancreatic ductal adenocarcinoma (PDAC) patients suffer poor outcomes, including a five-year survival of below 10%. Poor outcomes result in part from therapeutic resistance that limits the impact of cytotoxic first-line therapy. Novel therapeutic approaches are needed, but currently no targeted therapies exist to treat PDAC.
13p vimahuateng 26-11-2021 7 1 Download
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Single Nucleotide Polymorphism (SNP) in the genome has become crucial information for clinical use. For example, the targeted cancer therapy is primarily based on the information which clinically important SNPs are detectable from the tumor. Many hospitals have developed their own panels that include clinically important SNPs. The genome information exchange between the patient and the hospital has become more popular.
12p visilicon2711 20-08-2021 4 1 Download