Increase disease risk
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Dyslipidemia is one of the popular issues in developed countries and an increasing trend in developing countries. It is a major risk factor for cardiovascular disease, hypertension and diabetes. Polyherbal formulations have been used to treat dyslipidemia for many years. This study was designed to evaluate the effects of SAGYDI (SAD) on endogenous dyslipidemia experimental animal model.
8p vicarlos 16-05-2024 2 0 Download
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Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ), a severe neuropsychiatric disorder that is characterized by psychosis as well as multifactorial medical co-morbidities, including metabolic disease, contributing to markedly increased morbidity and mortality.
19p vibransone 28-03-2024 9 2 Download
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Increases in α-synuclein protein expression are suspected to increase the risk of the development of Parkinson’s disease (PD). A recent study has demonstrated that β2-adrenergic receptor (β2AR) agonists decrease histone acetylation in the α-synuclein gene and suppress transcription.
3p vioraclene 31-03-2024 3 2 Download
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Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive liver diseases. The confinement of HBV replication to the liver, which also acts as the central hub for metabolic and nutritional regulation, emphasizes the interlinked nature of host metabolism and the disease.
13p vioraclene 31-03-2024 6 2 Download
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Patients with certain genetic diseases, such as autism spectrum disorder, have increased rates of de novo mutations within some protein-coding genes. We introduce the VARiant PRIoritization SuM (VARPRISM), a software package which incorporates functional variant prioritization information to improve the power to detect de novo mutations influencing disease risk.
11p vioraclene 31-03-2024 1 1 Download
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The clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear. The PRSs derived and validated here highlight the potential for early genomic screening and personalized risk assessment for cardiovascular disease.
18p vibransone 28-03-2024 5 2 Download
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Multimorbidities greatly increase the global health burdens, but the landscapes of their genetic risks have not been systematically investigated. Methods: We used the hospital inpatient data of 385,335 patients in the UK Biobank to investigate the multimorbid relations among 439 common diseases. Post-GWAS analyses were performed to identify multimorbidity shared genetic risks at the genomic loci, network, as well as overall genetic architecture levels.
20p vibransone 28-03-2024 4 1 Download
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Health-related quality of life (HRQoL) is increasingly recognized as one of the goals of holistic healthcare. Crohn's disease is the most common inflammatory bowel disease that necessitates long-term management and increases the risk of psychological distress and social disruption, leading to impaired HRQoL in comparison to healthy controls.
13p vilarry 12-03-2024 5 1 Download
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Ebook "Studies in diabetes (Oxidative stress in applied basic research and clinical practice series)" examines how increased oxidative and nitrosative stress – one of the leading causes of diabetes complications – pathologically affects multiple tissues in the body. The volume editors and chapter authors are leading investigators in the field of basic and clinical research in diabetes and vascular disease.
277p manmanthanhla0201 26-02-2024 2 1 Download
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Ebook "Diagnostics in plant breeding" is systematically organizing cutting-edge research reviews on the development and application of molecular tools for the prediction of plant performance. Given its significance for mankind and the available research resources, medical sciences are leading the area of molecular diagnostics, where DNA-based risk assessments for various diseases and biomarkers to determine their onset become increasingly available.
517p lucchinguyen 28-12-2023 4 2 Download
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Brain cancer is one of the most aggressive cancer types owing to poor treatment effects. Epidemiological studies have demonstrated that allergies may increase the disease risk. Therefore, this study evaluated the association between eczema and the risk of various brain cancers.
9p vileonardodavinci 23-12-2023 5 2 Download
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Environmental injustice and health problems have been found detrimental to the quality of life in the West Bank. Insufficient water supply and unequal water distribution often lead to increased rates of communicable waterborne diseases and uncommunicable illnesses (World Health Organization, 2009).
9p vikissinger 21-12-2023 2 1 Download
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Previous studies have observed an increased incidence of Cetuximab-induced hypersensitivity infusion reactions (CI-IRs) in the southeastern states of the USA. Tick’s bites were suspected of generating cross-reactions between cetuximab and alpha-gal. This study aims was to describe the incidence and associated risk factors of CI-IRs, in the French areas chosen according to their Lyme disease incidence.
11p vileonardodavinci 23-12-2023 7 3 Download
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Breast cancer is an umbrella term referring to a group of biologically and molecularly heterogeneous diseases originating from the breast. Globally, incidences of breast cancer has been increasing dramatically over the past decades.
9p vileonardodavinci 23-12-2023 6 4 Download
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Myelodysplastic syndromes (MDS) are clonal hematopoietic diseases of the elderly characterized by chronic cytopenias, ineffective and dysplastic haematopoiesis, recurrent genetic abnormalities and increased risk of progression to acute myeloid leukemia.
10p vialfrednobel 23-12-2023 4 3 Download
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People who spend too much time being sedentary are more likely to develop musculoskeletal disorders and other non-communicable diseases (NCDs). This health risk is likely to increase with increasing sedentary office setting and lifestyle. In Kenya, the sedentary lifestyle is on the increase while its baseline data has not been documented appropriately.
28p vikissinger 21-12-2023 5 2 Download
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Residual fibroglandular breast tissue (RFGT) following a mastectomy has been claimed to be associated with the occurrence of an in-breast local recurrence (IBLR) or new primary tumor (NP). Yet, scientific evidence proving this assumption is lacking.
10p vischultz 20-10-2023 3 2 Download
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Anti−vascular endothelial growth factors (VEGFs) treatment has been associated with an increased risk of thromboembolic events. Therefore, the use of anti−VEGFs for patients with colorectal cancers (CRC) has raised concerns about the potential risk of retinal vein occlusion (RVO), an ocular disease caused by embolism or venous stasis.
11p visharma 20-10-2023 3 2 Download
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Dobutamine stress echocardiography is a safe diagnostic test with low incidence of serious complications. Atropine has been shown to reduce test duration without increasing the rate of complications.
4p viintuit 26-09-2023 0 0 Download
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Selenium (Se) is an essential trace element, and its deficiency in the humans leads to increase the risk of various diseases, such as cancer and heart diseases. The objective of this study was to investigate the influence of biofield energy treatment on the physical and thermal properties of the selenium powder. The selenium powder was divided into two parts denoted as control and treated.
6p viisac 23-09-2023 2 1 Download