Indicates genomic instability

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A prospective study on histone γ-H2AX and 53BP1 foci expression in rectal carcinoma patients: Correlation with radiation therapy-induced outcome

The prognostic value of histone γ-H2AX and 53BP1 proteins to predict the radiotherapy (RT) outcome of patients with rectal carcinoma (RC) was evaluated in a prospective study. High expression of the constitutive histone γ-H2AX is indicative of defective DNA repair pathway and/or genomic instability, whereas 53BP1 (p53-binding protein 1) is a conserved checkpoint protein with properties of a DNA double-strand breaks sensor.

10p vimoscow2711 29-08-2020 6 1 Download

Spatial UBE2N protein expression indicates genomic instability in colorectal cancers

One major hallmark of colorectal cancers (CRC) is genomic instability with its contribution to tumor heterogeneity and therapy resistance. To facilitate the investigation of intra-sample phenotypes and the de novo identification of tumor sub-populations, imaging mass spectrometry (IMS) provides a powerful technique to elucidate the spatial distribution patterns of peptides and proteins in tissue sections.

8p vikuala271 13-06-2020 9 1 Download