Individualized therapies

Street-connected individuals (SCI) in Kenya experience barriers to accessing HIV care. This pilot study provides proof-of-concept for Enabling Adherence to Treatment (EAT), a combination intervention providing modified directly observed therapy (mDOT), daily meals, and peer navigation services to SCI living with HIV or requiring therapy for other conditions (e.g. tuberculosis).

14p vithomson 25-07-2024 2 2   Download

Predicting short-term efficacy and intracranial progression-free survival (iPFS) in epidermal growth factor receptor gene mutated (EGFR-mutated) lung adenocarcinoma patients with brain metastases who receive third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy was of great significance for individualized treatment.

15p vishanshan 27-06-2024 1 1   Download

In the era of targeted therapies, the influence of aging on cancer management varies from one patient to another. Assessing individual frailty using geriatric tools has its limitations, and is not appropriate for all patients especially the youngest one.

8p vikoch 27-06-2024 1 1   Download

Ebook "Cell therapy: cGMP facilities and manufacturing" is an attempt to provide a written guide to how academic cell therapy product manufacturing facilities (usually referred to as Good Manufacturing Practice (GMP) facilities) operate. The aim is to share the common experience of individuals who have worked in the field. It has its origins in the contract facilities of the original Production Assistance for Cellular Therapies (PACT) group – at Universities of Minnesota and Pittsburgh and Baylor College of Medicine.

258p tracanhphuonghoa1007 22-04-2024 2 2   Download

Part 2 book "Psychology - A self teaching guide" includes content: Emotions - Riding life’s roller coaster; thinking - exploring mental life, intelligence - in pursuit of rational thought and effective action, developmental psychology - how children become adults, sex and love - are you in the mood; personality - psychological factors that make you an individual; abnormal psychology - exploring mental disorders; therapy - helping troubled people; social psychology - interacting with other people.

171p muasambanhan10 06-04-2024 5 1   Download

The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2-mutated breast or ovarian cancer.

12p vibransone 28-03-2024 3 2   Download

The human plasma proteome is important for many biological processes and targets for diagnostics and therapy. It is therefore of great interest to understand the interplay of genetic and environmental factors to determine the specific protein levels in individuals and to gain a deeper insight of the importance of genetic architecture related to the individual variability of plasma levels of proteins during adult life.

16p vibransone 28-03-2024 5 2   Download

Copaxone is an efficacious and safe therapy that has demonstrated clinical benefit for over two decades in patients with relapsing forms of multiple sclerosis (MS). On an individual level, patients show variability in their response to Copaxone, with some achieving significantly higher response levels.

15p vioraclene 31-03-2024 8 2   Download

Malignancies are molecularly complex and become more resistant with each line of therapy. We hypothesized that offering matched, individualized combination therapies to patients with treatment-naïve, advanced cancers would be feasible and efficacious.

14p vibransone 28-03-2024 2 2   Download

Drug resistance continues to be a major limiting factor across diverse anti-cancer therapies. Contributing to the complexity of this challenge is cancer plasticity, in which one cancer subtype switches to another in response to treatment, for example, triple-negative breast cancer (TNBC) to Her2-positive breast cancer

17p viellison 28-03-2024 3 2   Download

Renal cell carcinoma (RCC) is a heterogeneous disease comprising histologically defned subtypes. For therapy selection, precise subtype identification and individualized prognosis are mandatory, but currently limited. Our aim was to refne subtyping and outcome prediction across main subtypes, assuming that a tumor is composed of molecular features present in distinct pathological subtypes.

19p viellison 28-03-2024 4 2   Download

Although anti-apoptotic proteins of the B-cell lymphoma-2 (BCL2) family have been utilized as therapeutic targets in acute myeloid leukaemia (AML), their complicated regulatory networks make individualized therapy difficult.

13p viellison 28-03-2024 3 2   Download

We propose DEGAS (Diagnostic Evidence GAuge of Single cells), a novel deep transfer learning framework, to transfer disease information from patients to cells. We call such transferrable information “impressions,” which allow individual cells to be associated with disease attributes like diagnosis, prognosis, and response to therapy.

23p viellison 28-03-2024 3 2   Download

Ebook "Anticancer genes" discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as “Anticancer Genes”, are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application.

288p cotieubac1004 15-03-2024 5 0   Download

Pathogenic germline variants (PGVs) in certain genes are linked to higher lifetime risk of developing breast cancer and can influence preventive surgery decisions and therapy choices. Public health programs ofer genetic screening based on criteria designed to assess personal risk and identify individuals more likely to carry PGVs, dividing patients into screened and non-screened groups.

20p vicwell 29-02-2024 8 2   Download

The precise characterization of individual tumors and immune microenvironments using transcriptome sequencing has provided a great opportunity for successful personalized cancer treatment.

21p vicwell 29-02-2024 3 2   Download

Human immunodeficiency virus-1-associated neurocognitive disorder is a known complication in individuals treated with antiretroviral therapy. Cerebrospinal fluid escape, which is defined as discordant higher cerebrospinal fluid viremia than plasma, may occur in antiretroviral therapy-experienced individuals.

4p vigojek 02-02-2024 2 1   Download

The goal of research was to investigate the possible relations between serum concentrations of IL-6 and TGF-β1, individual and clinical characteristics, and adverse effects of radiotherapy in patients with prostate cancer: acute and late genitourinary and gastrointestinal toxicity, and fatigue.

14p vileonardodavinci 23-12-2023 6 2   Download

Ovarian strumal carcinoid is an extremely rare ovarian malignant tumor with limited data on clinical characteristics and survival outcomes. Patients with ovarian strumal carcinoid have an excellent prognosis irrespective of the surgical option. Conservative surgery especially USO with individualized adjuvant therapy is recommended.

9p vileonardodavinci 23-12-2023 8 3   Download

Evaluating the effects of cancer diagnosis and treatment on a patient’s overall well-being is crucial and health-related quality of life (HRQoL) is a reliable metric for assessing this impact. Little is known about HRQoL among cancer survivors across various stages and treatments. The study examined individual and clinical factors influencing HRQoL among cancer survivors.

13p vileonardodavinci 23-12-2023 2 2   Download