Inhibitors of acetylcholinesterase

The selective effects of these inhibitors are governed by substituent at position 5. Kinetic studies and molecular docking simulation were performed for elucidating mechanisms of enzyme-inhibitor complex formation.

12p tocectocec 25-05-2020 7 0   Download

Our recent studies have shown that, as indicated by vagal stimulation, an acetylcholinesterase inhibitor donepezil, an anti-Alzheimer’s disease drug, prevents progression of heart failure in rats with myocardial infarction, and activates a common cell survival signal shared by acetylcholine (ACh) in vitro.

15p vinaphone15 25-02-2013 33 3   Download

The hydrolysis of acetylthiocholine by acetylcholinesterase fromElectro-phorus electricuswas investigated in the presence of the inhibitors tacrine, gallamine and compound1. The interaction of the enzyme with the sub-strate and the inhibitors was characterized by the parametersKI , a¢, borb, Kmand Vmax, which were determined directly and simultaneously from nonlinear Michaelis–Menten plots.

16p viettel02 22-02-2013 24 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies

13p toshiba23 18-11-2011 79 3   Download