Inner cell mass

Cell division and death play an important role in embryonic development. Cell specialization is accompanied with slow proliferation and quiescence. Cell death is important for morphogenesis. Gene expression changes during differentiation is coordinated by lineage-specific transcription factors and chromatin factors. It is not yet fully understood how alterations in gene expression and cell cycle/death mechanisms are connected. We previously identified a chromatin protein Arid4b as a critical factor for meso/ endoderm differentiation of mouse embryonic stem cells (mESCs).

9p thiencuuchu 27-11-2021 10 1   Download

Little is understood of the molecular mechanisms involved in the earliest cell fate decision in human development, leading to the establishment of the trophectoderm (TE) and inner cell mass (ICM) stem cell population. Notably, there is a lack of understanding of how transcriptional networks arise during reorganisation of the embryonic genome post-fertilisation.

15p visilicon2711 20-08-2021 8 1   Download

The first distinct differentiation event in mammals occurs at the blastocyst stage when totipotent blastomeres differentiate into either pluripotent inner cell mass (ICM) or multipotent trophectoderm (TE). Here we determined, for the first time, global gene expression patterns in the ICM and TE isolated from bovine blastocysts.

13p vimariana2711 22-12-2020 6 0   Download

This study describes the generation and analysis of the transcriptional profile of bovine inner cell mass (ICM) and trophectoderm (TE), obtained from in vivo developed embryos by using a bovine-embryo specific array (EmbryoGENE) containing 37,238 probes.

13p viwyoming2711 16-12-2020 4 0   Download

Work in other species suggests that interleukin-6 (IL6) promotes early embryo development. It was unclear whether IL6 serves as an embryokine in cultured bovine embryos. This work was undertaken to elucidate the role of IL6 during in vitro bovine embryo production.

11p viwyoming2711 16-12-2020 9 0   Download

Aquarium fishes, like medaka, zebrafish and goldfish offer an excellent model to conduct studies on molecular mechanisms of embryonic developmental pathways, patterns of genes involved in pluripotency and cell fate decision. To determine the possible candidate gene as an ideal pluripotency marker in goldfish, the comparative study on quantitative expression of a set of genes were conducted in the mid-blastula derived inner cell mass (ICM) and adult somatic cells.

11p angicungduoc6 22-07-2020 12 2   Download

When studiedin vitro, mitochondrial permeability transition (MPT) is associated with an increase in mitochondrial per-meability to solutes up to 1500 Da in mass and a loss of electrical potential difference across the inner mitochondrial membrane (Dwmit). The MPT has been implicated as being important in cellular calcium homeostasis, autophagy and cell death via necrosis and apoptosis.

8p research12 23-04-2013 45 2   Download

The mitochondrial permeability transition pore is a high conductance chan-nel whose opening leads to an increase of mitochondrial inner membrane permeability to solutes with molecular masses up to
1500 Da. In this review we trace the rise of the permeability transition pore from the status ofin vitro artifact to that of effector mechanism of cell death.

23p inspiron33 26-03-2013 39 4   Download

Human embryonic stem cell (hESC) lines, like those from other species, are pluripotent cell lines derived from the inner cell mass (ICM) of the developing embryo. Due to their exceptional capability of proliferating indefi nitely as undifferentiated cells when cultured in appropriate conditions, and of sustaining a normal karyotype, hESCs may have broad applications for industrial uses; clinical purposes, namely, cell-based therapy; and research of early human development, differentiation mechanisms, and lineage commitment.

157p thienbinh1311 13-12-2012 50 7   Download