Integration of metabolomics
-
The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus occurs through complex organ-specific cellular mechanisms and networks contributing to impaired insulin secretion and insulin resistance. Genome-wide gene expression profiling systems can dissect the genetic contributions to metabolome and transcriptome regulations.
15p vioraclene 31-03-2024 4 2 Download
-
Spatial multi-omic studies have emerged as a promising approach to comprehensively analyze cells in tissues, enabling the joint analysis of multiple data modalities like transcriptome, epigenome, proteome, and metabolome in parallel or even the same tissue section. This review focuses on the recent advancements in spatial multi-omics technologies, including novel data modalities and computational approaches.
17p vicwell 29-02-2024 5 2 Download
-
Part 2 book "Comprehensive analysis of parasite biology" includes content: Methods to investigate metabolic systems in trypanosoma; the role of metabolomics in antiparasitic drug discovery; the importance of targeting lipid metabolism in parasites for drug discovery; carbon metabolism of plasmodium falciparum; mathematical modeling and omic data integration to understand dynamic adaptation of apicomplexan parasites and identify pharmaceutical targets; ... and other contents.
255p muasambanhan03 02-01-2024 7 2 Download
-
Ebook "Systems biology of marine ecosystems" describes the latest advances in systems biology in four plant-based marine ecosystems: seaweeds, seagrasses, microalgae, and corals. Marine organisms that inhabit the oceanic environment experience a diverse range of environmental fluctuations, anthropogenic stress, and threats from invasive species and pathogens.
355p lucchinguyen 28-12-2023 4 2 Download
-
Prostate cancer is a common solid tumor that affects a significant number of men worldwide. Conventional androgen deprivation therapy (ADT) increases the risk of developing castration-resistant prostate cancer (CRPC).
16p vileonardodavinci 23-12-2023 4 2 Download
-
Precision medicine has spurred new innovations in molecular pathology leading to recent advances in the analysis of exhaled breath as a non-invasive diagnostic tool. Volatile organic compounds (VOCs) detected in exhaled breath have the potential to reveal a wealth of chemical and metabolomic information.
13p viginny 23-12-2022 9 2 Download
-
Pathophysiology of transformation of inflammatory lesions in chronic pancreatitis (CP) to pancreatic ductal adenocarcinoma (PDAC) is not clear. Methods: We conducted a systematic review, meta-analysis of circulating metabolites, integrated this data with transcriptome analysis of human pancreatic tissues and validated using immunohistochemistry. Our aim was to establish biomarker signatures for early malignant transformation in patients with underlying CP and identify therapeutic targets.
13p vikolindagrabar 27-07-2022 9 3 Download
-
Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and nongenetic host factors.
22p viarchimedes 26-01-2022 11 0 Download
-
Isatidis Radix, the root of Isatis indigotica Fort. (Chinese woad) can produce a variety of efficacious compound with medicinal properties. The tetraploid I. indigotica plants exhibit superior phenotypic traits, such as greater yield, higher bioactive compounds accumulation and enhanced stress tolerance. In this study, a comparative transcriptomic and metabolomic study on Isatidis Radix autotetraploid and its progenitor was performed.
13p vitzuyu2711 29-09-2021 14 1 Download
-
We present results from a computational analysis developed to integrate transcriptome and metabolomic data in order to explore the heat stress response in the liver of the modern broiler chicken. Heat stress is a significant cause of productivity loss in the poultry industry, both in terms of increased livestock morbidity and its negative influence on average feed efficiency.
16p visilicon2711 20-08-2021 13 1 Download
-
Candida albicans is an opportunistic pathogenic yeast, which could become pathogenic in various stressful environmental factors including the spaceflight environment. In this study, we aim to explore the phenotypic changes and possible mechanisms of C. albicans after exposure to spaceflight conditions.
9p vijeeni2711 24-07-2021 11 0 Download
-
Sugarcane (Saccharum officinarum) is one of the most valuable feedstocks for sugar production. In addition to the production of industrial raw materials such as alcohol, papermaking, the fiber of livestock feed, respectively, sugarcane can produce bioactive compounds such as anthocyanins.
15p vijichea2711 28-05-2021 13 1 Download
-
Carotenoids and flavonoids are important secondary metabolites in plants, which exert multiple bioactivities and benefits to human health. Although the genes that encode carotenogenesis and flavonoid biosynthetic enzymes are well characterized, the transcriptional regulatory mechanisms that are related to the pathway genes remain to be investigated.
14p vijichea2711 28-05-2021 10 1 Download
-
Catechins, caffeine, and theanine as three important metabolites in the tea leaves play essential roles in the formation of specific taste and shows potential health benefits to humans. However, the knowledge on the dynamic changes of these metabolites content over seasons, as well as the candidate regulatory factors, remains largely undetermined.
14p vijichea2711 28-05-2021 8 1 Download
-
The objectives of this study were to reveal the anthocyanin biosynthesis metabolic pathway in white and purple flowers of Salvia miltiorrhiza using metabolomics and transcriptomics, to identify different anthocyanin metabolites, and to analyze the differentially expressed genes involved in anthocyanin biosynthesis.
13p vijichea2711 28-05-2021 12 1 Download
-
Safflower (Carthamus tinctorius L.) is an important cash crop, of which the dried tube flower is not only an important raw material for dyes and cosmetics but also an important herb widely used in traditional Chinese medicine.
12p vijichea2711 28-05-2021 13 1 Download
-
To fully elucidate the roles and mechanisms of plant hormones in leaf senescence, we adopted an integrated analysis of both non-senescing and senescing leaves from red maple with transcriptome and metabolome data.
22p vijichea2711 28-05-2021 10 1 Download
-
Petals are the colorful region of many ornamental plants. Quality traits of petal color directly affect the value of ornamental plants. Although the regulatory mechanism of flower color has been widely studied in many plants, that of lily flower color is still worth further exploration.
18p vijichea2711 28-05-2021 19 1 Download
-
Exposure to environmental tobacco smoke (ETS) leads to higher rates of pulmonary diseases and infections in children. To study the biochemical changes that may precede lung diseases, metabolomic effects on fetal and maternal lungs and plasma from rats exposed to ETS were compared to filtered air control animals.
15p viwyoming2711 16-12-2020 11 1 Download
-
Integrative network methods are commonly used for interpretation of high-throughput experimental biological data: Transcriptomics, proteomics, metabolomics and others.
20p vikentucky2711 24-11-2020 15 1 Download