Integrative therapies
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For patients with locally advanced rectal cancer (LARC), total neoadjuvant therapy (TNT), namely, intensifying preoperative treatment through the integration of radiotherapy and systemic chemotherapy before surgery, was commonly recommended as the standard treatment.
10p vishanshan 27-06-2024 1 1 Download
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Paclitaxel is commonly used as a second-line therapy for advanced gastric cancer (AGC). The decision to proceed with second-line chemotherapy and select an appropriate regimen is critical for vulnerable patients with AGC progressing after first-line chemotherapy.
9p vishanshan 27-06-2024 2 1 Download
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Breast cancer remains a significant health challenge worldwide, necessitating the identification of reliable biomarkers for early detection, accurate prognosis, and targeted therapy.
13p vikoch 27-06-2024 1 1 Download
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Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC ) stands out as a potential candidate for new therapies.
17p vikoch 27-06-2024 3 1 Download
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Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients’ treatment options.
22p vibransone 28-03-2024 3 2 Download
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Genomic medicine has considerable potential to provide novel diagnostic and therapeutic solutions for patients who have molecularly complex diseases and who are not responding to existing therapies. To bridge the gap between genomic medicine and clinical practice, integration of various data types, resources, and joint international initiatives will be required.
3p vibransone 28-03-2024 3 2 Download
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Clear cell renal cell carcinoma (ccRCC) is the dominant subtype of renal cancer. With currently available therapies, cure of advanced and metastatic ccRCC is achieved only in rare cases. Here, we developed a workflow integrating different -omics technologies to identify ccRCC-specific HLA-presented peptides as potential drug targets for ccRCC immunotherapy.
24p vibransone 28-03-2024 2 1 Download
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Personalized therapy provides the best outcome of cancer care and its implementation in the clinic has been greatly facilitated by recent convergence of enormous progress in basic cancer research, rapid advancement of new tumor profiling technologies, and an expanding compendium of targeted cancer therapeutics.
20p vioraclene 31-03-2024 2 2 Download
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Telomeres maintain genomic integrity in normal cells, and their progressive shortening during successive cell divisions induces chromosomal instability. In the large majority of cancer cells, telomere length is maintained by telomerase. Thus, telomere length and telomerase activity are crucial for cancer initiation and the survival of tumors.
18p vioraclene 31-03-2024 1 1 Download
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Single liquid biopsy analytes (LBAs) have been utilized for therapy selection in metastatic breast cancer (MBC). We performed integrative statistical analyses to examine the clinical relevance of using multiple LBAs: matched circulating tumor cell (CTC) mRNA, CTC genomic DNA (gDNA), extracellular vesicle (EV) mRNA, and cellfree DNA (cfDNA).
14p vibransone 28-03-2024 3 2 Download
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Although immune checkpoint inhibitor (ICI) is regarded as a breakthrough in cancer therapy, only a limited fraction of patients benefit from it. Cancer stemness can be the potential culprit in ICI resistance, but direct clinical evidence is lacking.
18p viellison 28-03-2024 5 1 Download
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Tamoxifen is used in low dose concentrations (20–40 mg per day) as a therapy for breast cancer but is known to have ocular side effects. In this case report, the foveal cone integrity in a tamoxifen-treated patient who complained of a small central scotoma in the left eye while reading was examined using high-resolution adaptive optics imaging.
5p vitiki 30-01-2024 2 2 Download
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Part 2 book "Laser therapy in veterinary medicine - Photobiomodulation" includes content: Clinical applications of laser therapy in companion animal rehabilitation, clinical applications of laser therapy in exotic animals, clinical applications of laser therapy in equine practice, clinical applications of laser therapy in food animal practice, laser therapy and alternative and regenerative therapies, integrating laser therapy into veterinary medicine.
253p muasambanhan05 22-01-2024 4 2 Download
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Part 2 book "Equine neck and back pathology - Diagnosis and treatment" includes content: Nuclear scintigraphy and computed tomography of the neck, back and pelvis; ultrasonography; thermography; neck pathology; back pathology; sacroiliac dysfunction; muscular disorders; integrative and physical therapies; rehabilitation.
183p muasambanhan03 02-01-2024 5 2 Download
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Ebook "Bioinformatics for diagnosis, prognosis and treatment of complex diseases" introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases.
219p lamquandat 28-12-2023 10 2 Download
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Currently, main treatment strategies for early-stage non-small cell lung cancer (ES-NSCLC) disease are surgery or stereotactic body radiation therapy (SBRT), with successful local control rates for both approaches.
7p vileonardodavinci 23-12-2023 2 2 Download
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Prostate cancer is a common solid tumor that affects a significant number of men worldwide. Conventional androgen deprivation therapy (ADT) increases the risk of developing castration-resistant prostate cancer (CRPC).
16p vileonardodavinci 23-12-2023 4 2 Download
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Brain metastases (BMs) are the most frequent intracranial tumours associated with poor clinical outcomes. Radiotherapy is essential in the treatment of these tumours, although the optimal radiation strategy remains controversial. The present study aimed to assess whether whole brain radiation therapy with a simultaneous integrated boost (WBRT + SIB) provides any therapeutic beneft over WBRT alone.
12p vileonardodavinci 23-12-2023 6 3 Download
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Lipid metabolism has a profound impact on gastric cancer (GC) progression and is a newly targetable vulnerability for cancer therapy. Given the importance of lipids in cancer cellular processes, in this study we employed lipidomic clinical and transcriptomic data to connect the variations of lipid metabolism changes of GC.
13p vialfrednobel 23-12-2023 6 3 Download
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To detect the HPV genotype and integration sites in patients with high-risk HPV infection at different stages of photodynamic therapy using nanopore technology and to evaluate the treatment effect.
12p vialfrednobel 23-12-2023 6 3 Download