Iron homeostasis

Hepcidin (H25) is a hormone peptide synthesized by the liver that binds to ferroportin and blocks iron export. In this study, H25 was inhibited by administration of single and multiple doses of an anti-H25 monoclonal antibody Ab 12B9m in cynomolgus monkeys. The objective of this analysis was to develop a pharmacodynamic model describing the role of H25 in regulating iron homeostasis and the impact of hepcidin inhibition by Ab 12B9m. Total serum H25 and Ab 12B9m were determined in each animal. Corresponding measurements of serum iron and hemoglobin (Hb) were obtained.

15p caothientrangnguyen 09-05-2020 13 1   Download

The discovery of iron-responsive elements (IREs), along with the identifica-tion of iron regulatory proteins (IRP1, IRP2), has provided a molecular basis for our current understanding of the remarkable post-transcriptional regulation of intracellular iron homeostasis. In iron-depleted conditions, IRPs bind to IREs present in the 5¢-UTR of ferritin mRNA and the 3¢-UTR of transferrin receptor (TfR) mRNA.

9p inspiron33 25-03-2013 41 3   Download

Hemopexin (HPX), which serves as a scavenger and transporter of toxic plasma heme, has been postulated to play a key role in the homeostasis of NO. In fact, HPX–heme(II) reversibly binds NO and facilitates NO scaven-ging by O2. HPX–heme is formed by two four-bladed b-propeller domains. The heme is bound between the twob-propeller domains, residues His213 and His266 coordinate the heme iron atom.

12p inspiron33 23-03-2013 43 5   Download

Recent discoveries have indicated that the hormone hepcidin plays a major role in the control of iron homeostasis. Hepcidin regulates the iron level in the blood through the interaction with ferroportin, an iron exporter molecule, causing its internalization and degradation.

10p viettel02 22-02-2013 39 3   Download

Control of transferrin expression by b-amyloid through the CP2 transcription factor Sang-Min Jang1,*, Jung-Woong Kim1,*, Chul-Hong Kim1, Joo-Hee An1, Eun-Jin Kang1, Chul Geun Kim2, Hyun-Jung Kim3 and Kyung-Hee Choi1 1 Department of Life Science (BK21 Program), College of Natural Sciences, Chung-Ang University, Seoul, Korea 2 Department of Life Science and Research Institute for Natural Sciences, Hanyang University, Seoul, Korea 3 College of Pharmacy, Chung-Ang University, Seoul, Korea Keywords Alzheimer’s disease; CP2; iron homeostasis; oxidative stress; transferrin Correspondence K.-H.

12p viettel02 19-02-2013 32 3   Download

The iron responsive regulator Irr is found in a wide range ofa-proteobac-teria, where it regulates many genes in response to the essential but toxic metal iron. Unlike Fur, the transcriptional regulator that is used for iron homeostasis by almost all other bacterial lineages, Irr does not sense Fe 2+ directly, but, rather, interacts with a physiologically important form of iron, namely heme.

11p cosis54 05-01-2013 44 4   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Transcriptome analysis by GeneTrail revealed regulation of functional categories in response to alterations of iron homeostasis in Arabidopsis thaliana

10p panasonic02 14-12-2011 68 4   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study

8p toshiba12 21-10-2011 60 4   Download