Iron transport

Ebook "Molecular biology of metal homeostasis and detoxification: From microbes to man" brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription.

519p ladongphongthanh1008 22-04-2024 7 2   Download

Ebook "Iron uptake in bacteria with emphasis on E. coli and Pseudomonas" reviews the recent advancements in the field of iron transport systems in bacteria. Chapter 1 is dedicated to Dr. Dick van der Helm’s contribution to the field of siderophore biology. It then describes and discusses the structural advances in the components and the mechanism of siderophore mediated iron transport systems in E.coli. Chapter 2 details the variety of iron transport and iron regulatory systems of both gram negative and gram positive bacteria.

98p coduathanh1122 27-03-2024 2 1   Download

Rice (Oryza sativa L.) is one of the major food crops but is deficient in minerals such as Zn. In rice, there were eight genes belonging to the Natural resistance-associated macrophage protein (NRAMP) family, of which OsNRAMP1, OsNRAMP4, OsNRAMP5, OsNRAMP6, and OsNRAMP8 were reported to transport metals such as iron (Fe), zinc, mangan (Mn).

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Gram-negative bacterium Neisseria meningitidis, responsible for human infectious disease meningitis, acquires the iron (Fe3+) ion needed for its survival from human transferrin protein (hTf). For this transport, transferrin binding proteins TbpA and TbpB are facilitated by the bacterium. The transfer cannot occur without TbpA, while the absence of TbpB only slows down the transfer. Thus, understanding the TbpA-hTf binding at the atomic level is crucial for the fight against bacterial meningitis infections.

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GTN stimulation increased both CRLR/ CGRPR1 expression, and immunostaining was apparent in microglia and meningeal cells. This study showed for the first time that GTN modulates intracellular iron trafficking regulated by storage and transport proteins expressed in meningeal cells and glia. CRLR/ CGRPR1 expression might be related to altered iron homeostasis and they both may stimulate nociceptive pathways activated in migraine.

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Aedes aegypti is the principle vector of many arboviruses, including dengue virus and Zika virus, which are transmitted when an infected female mosquito takes a blood meal in order to initiate vitellogenesis. During blood digestion, ~ 10 mM heme-iron is ingested into the midgut lumen.

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The low yield of pulses is mainly attributed to their cultivation on poor soils with inadequate and imbalanced nutrient application without the application of organic manures and micronutrients like boron, zinc and iron. Since the poor soils are low in organic matter content, use of organic manures plays a vital role in improving soil physical condition, provides vital plant nutrients and maintains long term productivity of the soil. Boron helps in carbohydrate transport. It is necessary for the germination of pollen, formation of flowers and fruits and for the absorption of cations.

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Iron is one of the essential mineral for all organisms and its deficiency leads to many serious problems in human being worldwide. Plants have evolved with specific ZIP transporters to uptake and transport the iron from the soil. IRT2 is one of the ZIPs family members, which has a role in uptake of Fe2+ from the soil. Indian barnyard millet (E. frumentacea L.) is one of the rich sources of iron among millets. IRT2 gene of Indian barnyard millet is up regulated under iron deficient condition and hence we isolated EfIRT2 gene.

12p angicungduoc6 20-07-2020 12 1   Download

Ba Lat estuary is the large mouth of the Red river; every year, the Ba Lat estuary receives million cubic meters of water before the water is dissolved in the sea. Therefore, polluted materials in the water from the continent are also transported to the sea through the estuary. However, the volume of the water pouring into the sea varies with the season. In this paper, the water quality at Ba Lat estuary (Red river) was surveyed in July 2017 representing the Southwest wind season (rainy season) and in October 2017 representing the Northeast wind season (dry season).

9p caygaocaolon6 22-07-2020 23 2   Download

During wheat senescence, leaf components are degraded in a coordinated manner, releasing amino acids and micronutrients which are subsequently transported to the developing grain.

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Resequencing can be used to identify genome variations underpinning many morphological and physiological phenotypes. Legume model plant Medicago truncatula ecotypes Jemalong A17 (J. A17) and R108 differ in their responses to mineral toxicity of aluminum and sodium, and mineral deficiency of iron in growth medium.

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Plant adaptation to limited phosphate availability comprises a wide range of responses to conserve and remobilize internal phosphate sources and to enhance phosphate acquisition. Vigorous restructuring of root system architecture provides a developmental strategy for topsoil exploration and phosphate scavenging.

21p vihashirama2711 21-05-2020 8 0   Download

Iron is an essential micro-mineral in human nutrition. It is a mineral found in every cell of the body and required to make part of blood cell. It participates as a catalyst in several metabolic reactions. As a component of haemoglobin, myoglobin, cytochrome and other proteins, iron plays an important role in the transport, storage and utilization of oxygen and cellular proliferation. In this study, an attempt was made to prepare dahi by using 1% starter culture, fortified with iron by using ferrous lactate @ 40 mg/kg milk.

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Hepcidin (H25) is a hormone peptide synthesized by the liver that binds to ferroportin and blocks iron export. In this study, H25 was inhibited by administration of single and multiple doses of an anti-H25 monoclonal antibody Ab 12B9m in cynomolgus monkeys. The objective of this analysis was to develop a pharmacodynamic model describing the role of H25 in regulating iron homeostasis and the impact of hepcidin inhibition by Ab 12B9m. Total serum H25 and Ab 12B9m were determined in each animal. Corresponding measurements of serum iron and hemoglobin (Hb) were obtained.

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MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level in eukaryotes. In rice, MIR7695 expression is regulated by infection with the rice blast fungus Magnaporthe oryzae with subsequent down-regulation of an alternatively spliced transcript of natural resistanceassociated macrophage protein 6 (OsNramp6). NRAMP6 functions as an iron transporter in rice.

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Iron has an important role in various metabolic processes and as a central structure of hemoglobin (Hb) for the process of transporting oxygen. Malnutrition from the beginning of pregnancy until the end of pregnancy will cause problems with labor, premature birth, low birth weight in infants to maternal death. The importance of examining serum Ferritin levels as early detection of iron deficiency anemia is especially carried out before pregnancy or early pregnancy (trimester I), given the high incidence of iron deficiency anemia in pregnant women and its impacts.

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Deficiency of micronutrients in soil particularly, that of Fe is a major nutritional and production constraint worldwide. We hypothesize a role of sulphur nutrition in altering the Fe deficiency tolerance response of crop plants. Present investigation was conducted to elucidate the role of S in regulating uptake and in-plant partitioning of Fe in bread and durum wheat through a field and a nutrient solution culture experiment.

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An experimental setup allowing pH measurements inside a confined volume representing a lapped joint was designed in our last study [1]. The pH evolution over steel surface in confined conditions was monitored. In this study, the experimental pH was compared with that calculated using a two-dimensional transport-reaction model only in the case of a confined iron surface.

9p abcxyz123_02 03-03-2020 10 1   Download

Iron and Zinc are the key ingredient in human nutrition, soil and crop management. Rice is the major dietary source for the population in India but it is deficient in iron and zinc. An effort was made to quantify the iron and zinc content in brown, white and cooked white rice and to study the effect of nucleotide variations in genes associated with zinc. 14 genotypes were selected and grown in field at UAS, GKVK in RCBD, during Kharif-2014. Quality parameter zinc in brown rice showed negative effect on yield.

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Diabetic osteoporosis is gradually attracted people's attention. However, the process of bone microstructure changes in diabetic patients, and the exact mechanism of osteoblast iron overload are unclear.

9p viwashington2711 04-12-2019 10 1   Download