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JNK pathway activation
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In ebook "Stress-activated protein kinases" leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signalling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signalling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis.
322p
tachieuhoa
28-01-2024
4
2
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Cancerous inhibitor of PP2A (CIP2A) is a recently characterized oncoprotein, which promotes cancer cell proliferation. But the role of CIP2A in lung cancer progression is still not well understood. Methods: The expression level of CIP2A in lung cancer tissues was examined by immunohistochemistry. CIP2Aassociated cell proliferation was performed by knock down or overexpression of CIP2A in lung cancer cells.
11p
vimoscow2711
29-08-2020
17
2
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The aim of this study was to explore the efficacy and define mechanisms of action of PRIMA-1MET as a TP53 targeted therapy in soft-tissue sarcoma (STS) cells. Methods: We investigated effects of PRIMA-1MET on apoptosis, cell cycle, and induction of oxidative stress and autophagy in a panel of 6 STS cell lines with different TP53 status.
8p
vimoscow2711
29-08-2020
8
1
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Renal cell carcinoma (RCC) is one of the tumors most refractory to chemotherapy to date. Therefore, novel therapeutic agents are urgently needed for this disease. Capsaicin (CPS), a natural active ingredient of green and red peppers, and a ligand of transient receptor potential vanilloid type 1 (TRPV1), has been showed potential in suppression of tumorigenesis of several cancers.
13p
vimale2711
25-08-2020
13
2
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Rac1, known as a “molecular switch”, plays a crucial role in plenty of cellular processes. Rac1 aggravates the damage of myocardial cells in the process of myocardial ischemia-reperfusion during myocardial infarction through activating the NADPH oxidase and bringing about the reactive oxygen species(ROS) generation.
10p
vihasaki2711
12-11-2019
17
1
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This study aims to explore the role and the possible underlying molecular mechanism of SNF5 in the pathogenesis of rheumatoid arthritis (RA). MH7A cells were respectively transfected with pc-SNF5 (pcDNA3.1 containing the Brg1 coding sequence), short hairpin RNA against SNF5 (shSNF5), and their negative controls (pcDNA3.1 and shNC).
8p
nutifooddau
27-01-2019
13
1
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Interleukin-1 (IL-1) induces multiple genes via activation of transcription factors that include NF-jB and activator protein-1 (AP-1).We found that IL-1-mediated c-Src acti-vation was required for AP-1 activation, but not for NF-jB activation and also revealed that c-Src-induced AP-1 acti-vation was enhanced synergistically by the coexpression of TNF receptor associated factor 6 (TRAF6).In addition, c-Src interacts with TRAF6 in response to IL-1 and this interaction is required for c-Src activity....
12p
tumor12
20-04-2013
51
1
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Leucine zipper-bearing kinase (LZK) is a novel member of themixed lineage kinase (MLK) family [Sakuma, H., Ikeda, A.,Oka,S.,Kozutsumi,Y.,Zanetta,J.P., andKawasaki, T. (1997)J. Biol.Chem.272, 28622–28629].Wehavepreviously shown that LZK activates the c-Jun-NH2terminal kinase (JNK) pathway, but not the extracellular signal-related kinase (ERK) pathway, by acting as a mitogen-activated protein kinase kinase kinase (MAPKKK) [Ikeda, A., Hasegawa, K., Masaki, M., Moriguchi, T., Nishida, E., Kozutsumi, Y., Oka, S., and Kawasaki, T. (2001)J. Bio-chem.130, 773–781]....
8p
tumor12
20-04-2013
23
2
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Ubiquitination and proteasomal degradation have recently emerged as an additional level of regulation of activated forms of Rho GTPases. To char-acterize this novel regulatory pathway and to gain insight into its biological significance, we studied the ubiquitination of two constitutively activated forms of Rac1, i.e.
11p
media19
05-03-2013
37
1
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Screening a compound library of compound 48⁄80 analogues, we identified 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate (E1) as a novel inhibitor of the phosphoinositide 3-kinase⁄Akt pathway. In order to determine the mechanism of action of E1, we analysed the effect of E1 on components of the phosphoinositide 3-kinase⁄Akt⁄mammalian target of rapamycin (mTOR) pathway.
14p
vinaphone15
25-02-2013
37
0
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Chronic high doses of morphine inhibit the growth of various human cancer cell lines. However, the mechanisms by which such high-dose morphine inhibits cell proliferation and induces cell death are not fully understood. Here we show that c-Jun N-terminal kinase (JNK) plays a pivotal role in high-dose morphine-induced apoptosis of SH-SY5Y cells in a mitochondria-dependent manner.
15p
viettel02
22-02-2013
23
1
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Activation of the c-JUN N-terminal kinase (JNK) pathway is implicated in a number of important physiological processes, from embryonic morpho-genesis to cell survival and apoptosis. JNK stimulatory phosphatase 1 (JSP1) is a member of the dual-specificity phosphatase subfamily of protein tyrosine phosphatases.
11p
mobifone23
21-01-2013
46
2
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin...
13p
thulanh27
13-12-2011
36
2
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Endotoxin-activated microglia injure brain derived endothelial cells via NF-B, JAK-STAT and JNK stress kinase pathways...
15p
thulanh27
12-12-2011
44
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Lipopolysaccharide-induced Notch signaling activation through JNK-dependent pathway regulates inflammatory response...
9p
toshiba23
21-11-2011
29
2
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways
11p
toshiba23
18-11-2011
40
1
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways...
17p
toshiba11
19-10-2011
43
2
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes...
9p
thulanh13
15-10-2011
39
1
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis...
10p
toshiba10
15-10-2011
42
1
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