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Keratin associated protein
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According to our results, the N-terminal kinase domain of RIPK4 is responsible for KRT14–RIPK4 interaction; however, the RIPK4 kinase activity is dispensable for the interaction. In accordance with their interaction, RIPK4 and KRT14 colocalize within the cells, particularly at keratin filaments associated with perinuclear ring-like structures. Moreover, RIPK4 did not show any effect on KRT14/KRT5 heterodimer formation. Our results suggest that RIPK4 may regulate the keratin turnover required for keratinocyte differentiation through interacting with KRT14.
11p
thiencuuchu
27-11-2021
7
1
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Keratin-associated proteins are fibrillar proteins and are the vital components of hair and wool fibres as they are part of matrix of fibres and form a cross- linked network with the keratin intermediate filaments. Variation in sequence and expression pattern of KAP may affect fibre characteristics. In this study, we used direct DNA sequencing to analyse the goat HGT-KAP 7.1gene which codes for the protein responsible for the fineness of fibre.
5p
caygaocaolon8
07-11-2020
10
1
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The Hippo pathway plays a vital role in liver regeneration and development by determining cellular lineage and regulating cell proliferation and apoptosis. In this study, we aimed to assess the role of the Hippo pathway in hepatic carcinogenesis and morphogenesis by examining Yes-associated protein 1 (YAP1) expression in the spectrum of hepatic carcinomas based on cellular lineage.
9p
vidhaka2711
31-07-2020
13
1
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