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Kidney toxicity
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This research was carried out to evaluate the acute and sub-chronic toxicity of ‘‘Huyet phu truc u hoan’’ (HPTUH) in experimental animals. The acute toxicity was defined on Swiss mice by the Litchfield – Wilcoxon’s method and the sub-chronic toxicity on Wistar rat’s hematopoietic function, liver, and kidney functions according to the World Health Organization Guidance.
10p
vikoch
27-06-2024
2
1
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This research aimed to evaluate the subchronic toxicity of Diabetna capsules through oral administration in experimental animals. Our result showed that Diabetna capsules had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and microscopic images of the livers and kidneys of Wistar rats.
9p
vikoch
27-06-2024
2
1
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Robotic-assisted surgeries have gradually become the standard of care for many procedures, especially in the field of urology. Despite the widespread use of robotic assistance in surgeries, data on its postoperative complications are extremely limited.
5p
vitiki
30-01-2024
7
3
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Methotrexate (MTX) is a chemotherapy and immunosuppressive agent widely used to treat cancer, autoimmune diseases in children and adult patients, and ectopic pregnancy. However, MTX is highly toxic to the liver, kidney, and nervous system. This study aimed to quantify the concentration of MTX in human plasma using high-performance liquid chromatography (HPLC).
6p
vikissinger
21-12-2023
1
1
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Carboplatin is the backbone cytotoxic agent for many chemotherapy regimens for lung cancer. Dosing of carboplatin is complicated due to its relationship to renal function and narrow therapeutic index. Overestimation of renal function may lead to supratherapeutic dosing and toxicity, while underestimation may lead to underdosing and therapeutic failure.
15p
vileonardodavinci
23-12-2023
7
3
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Part 1 book "Casarett and Doull's toxicology - The basic science of poisons" includes content: History and scope of toxicology; principles of toxicology; mechanisms of toxicity; risk assessment; absorption, distribution, and excretion of toxicants; biotransformation of xenobiotics; toxicokinetics8. chemical carcinogenesis; genetic toxicology; developmental toxicology11. toxic responses of the blood; toxic responses of the immune system; toxic responses of the liver; toxic responses of the kidney; toxic responses of the respiratory system.
751p
muasambanhan01
11-12-2023
3
2
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Part 2 book "An introduction to toxicology" includes content: Target organ toxicity - liver and kidney, chemicals and the unborn, chemicals and cancer, everyday toxicology I - Alcohol, everyday toxicology II - Tobacco.
175p
oursky05
23-10-2023
7
3
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In view of the toxic effects of theobromine and the medicinal potentials of Vernonia amygdalina, the present study therefore evaluated the effect of ethanol leaf extract of Vernonia amygdalina on the heart, liver and kidney of theobromine intoxicated male albino rats.
9p
viisac
23-09-2023
4
1
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Polyethylene glycol (PEG) 3350, an active ingredient of over-thecounter MiraLAX, is a commonly used laxative in children and is produced by polymerization of ethylene glycol (EG). Masked EG toxicity secondary to contamination of PEG 3350 could occur.
7p
viwhitewolf
03-07-2023
2
2
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Acute liver failure (ALF) is a rare condition that can have a variable clinical course and potentially fatal outcomes. Medication toxicity is a known etiology, however liver failure induced by amiodarone is rare and has been reported mostly in the setting of intravenous (IV) infusion.
5p
viwhitewolf
03-07-2023
2
2
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Targeted therapy with anaplastic lymphoma kinase inhibitor alectinib has become standard therapy for selected patients with non-small cell lung carcinoma. Few data are available on the renal effects of alectinib. We report on a case of acute kidney injury in a patient using alectinib for less than 2 weeks and on serum sodium and creatinine during long-term use of alectinib.
5p
vigamora
23-05-2023
5
2
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Perchloroethylene is a colorless, strong-smelling substance commonly used for dry cleaning. Liver and kidney toxicities and carcinogenicity are well-known occupational hazards caused by chronic perchloroethylene exposure.
6p
vigamora
23-05-2023
4
2
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The current study includes the histopathological alterations induced by chronic (20 days) exposure of the fish Anabas testudineus to a sublethal concentrations (27.5 mg/L) of inorganic fertilizer, Urea [CO(NH2)2]. Some vital organs were taken for the study that is kidney, liver, intestine, testis and ovary. The present study showed major histopathological alteration like vacuolar degenerative changes, necrosis etc. found in liver, intestine, testis, ovary and kidney organs dysfunction in response to urea toxicity effect in the fish A. testudineus.
10p
chauchaungayxua12
29-07-2021
11
2
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Hydrazine (N2H4) is an important and commonly used chemical reagent for the preparation of textile dyes, pharmaceuticals, pesticides and so on. Despite its widespread industrial applications, hydrazine is highly toxic and exposure to this chemical can cause many symptoms and severe damage to the liver, kidneys, and central nervous system. As a consequence, many efforts have been devoted to the development of fluorescent probes for the selective sensing and/or imaging of N2H4.
21p
hongnguyenwin
24-07-2021
10
0
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The current study includes the histopathological alterations induced by chronic (20 days) exposure of the fish Anabas testudineus to a sublethal concentration (0.092 g/L) of inorganic fertilizer, Di-ammonium phosphate. Some vital organs were taken for the study that is kidney, liver, intestine, testis and ovary. The present study showed major histopathological alteration like vacuolar degenerative changes, necrosis etc. found in liver, intestine, testis, ovary and kidney organs dysfunction in response to DAP toxicity effect in the fish A. testudineus.
9p
cothumenhmong11
11-05-2021
10
1
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The impact of such recommendations after their implementation of guidelines has not usually been evaluated. Herein, we assessed the impact and compliance with the Spanish Oncology Genitourinary Group (SOGUG) Guidelines for toxicity management of targeted therapies in metastatic renal cell carcinoma (mRCC) in daily clinical practice.
10p
vinaypyidaw2711
26-08-2020
12
2
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Phenol is a toxic hydrocarbon for nervous system, kidneys, liver, muscles and immune system. It is also mutagenic and possibly carcinogenic. Phenol containing- pollutants are dangerous and spread worldwide in the industrial effluents.The present study aimed to isolate a potent microorganism able to degrade phenol, as well as to evaluate the nutritional and environmental conditions that lead to its maximum degradation. A yeast isolated from petroleum-contaminated soil on MSM supplemented with phenol as sole carbon source, was identified by 28S rDNA sequencing.
13p
nguaconbaynhay6
24-06-2020
11
0
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The potential for a compound to cause hepatotoxicity and nephrotoxicity is a matter of extreme interest for human health risk assessment. To assess liver and kidney toxicity, repeated-dose toxicity (RDT) studies are conducted mainly on rodents.
11p
vijiraiya2711
27-05-2020
6
1
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Colchicine is a natural alkaloid that is mainly used for the treatment of inflammatory diseases. Effective and toxic doses are very similar, but case reports of higher colchicine doses inducing acute toxicosis is rare.
6p
vimax2711
30-03-2020
17
1
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The present study aimed to assess the acute toxicity effects of herbicide, glyphosate on Nile tilapia (Oreochromis niloticus). The bioassay experiments were performed in a static renewal regime with Oreochromis niloticus exposing to varying acute toxicity concentrations of glyphosate viz., 15.33, 30.67, 61.34, 122.68 and 245.36 mg/l for 96 hrs and the gill, liver and kidney tissues were dissected out. The standard histology protocol was followed to study the histological alterations. In the present study, 100 % mortality was observed in concentrations of 122.68 and 245.
8p
caygaocaolon2
11-03-2020
16
1
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