Knowledge and natural

The rationale for this study is that the social enterprise sector provides an important locale in which to situate research that aims to identify the impact of ICTs on development. Recognising the complex dynamics and range of actors involved in this diverse and emerging area of development practice, this study chooses to focus on the social enterprise sector. It is specifically concerned with mapping the external influences, use and impact of ICT on social enterprises in Cambodia.

228p runthenight04 02-02-2023 22 3   Download

The study was carried out during 2013-14 in Meerut district of Uttar Pradesh state to focus on the sugarcane growers regarding impact of knowledge on adoption level of IPM practices. The 80 contact farmers were selected as respondents. The study revealed that the maximum knowledge gap was found to be existing in previous crop residues, crop rotation, hand picking of the insect and their destruction, hot air and water treatment, light and pheromone trap, microbial control, use of natural enemies, resistant varieties, biopesticides/ bio-agents, application and dose of different pest etc.

7p chauchaungayxua6 26-06-2020 21 3   Download

Development of knowledge of cardiovascular diseases and treatments strongly depends on understanding of hemodynamic measurements. Hemodynamic parameters, therefore, have been investigated using simulation-based methods.

10p tohitohi 19-05-2020 17 1   Download

Lecture “Natural language processing - Chapter 2: Fundamental algorithms and mathematical models” has contents: Probability theory and Bayes theorems (Concepts in probability, Bayes theorems, application of the probability theory in NLP).

14p dien_vi01 21-11-2018 34 1   Download

Lecture “Natural language processing - Chapter 1: Introduction and Overview of NLP” has contents: Introduce some of the classical problems in NLP, learn to address empirical problems, talk/write clearly about your work, decision and observations.

12p dien_vi01 21-11-2018 33 1   Download

The study is basically studied the syntactic, semantic and cultural characteristics of English idioms and proverbs relating to women in comparison with Vietnamese ones. More importantly, providing language learners with a basic knowledge of this field will help them master the meaning of idioms and proverbs, and easily and naturally translating them to each of these languages.

12p bautroibinhyen27 04-05-2017 211 18   Download

In order to study some of its enzymatic properties, phosphatidylinositol synthase 1 (AtPIS1) from the plant Arabidopsis thaliana was expressed in Escherichia coli, a host naturally devoid of phosphatidylinositol (PtdIns). In the context of the bacterial membrane and in addition to de novo synthesis, the plant enzyme is capable of catalysing the exchange of the inositol polar head for another inositol. Our data clearly show that the CDP-diacylglycerol-independent exchange reaction can occur using endogenous PtdIns molecular species or PtdIns molecular species from soybean added exogenously....

6p research12 01-06-2013 34 5   Download

Lipid rafts are liquid-ordered membrane microdomains with a unique protein and lipid composition found on the plasma membrane of most, if not all, mammalian cells. A large number of signalling molecules are concentrated within rafts, which have been proposed to function as signalling centres capable of facilitating efficient and specific signal transduction. This review summarizes current knowledge regarding the composition, structure, and dynamic nature of lipid rafts, as well as a number of different signalling path- ways that are compartmentalized within these microdomains....

16p research12 01-06-2013 37 3   Download

The solution structure of three small serine proteinase inhibitors, two natural and one engineered protein, SGCI (Schistocerca gregaria chymotrypsin inhibitor), SGCI[L30R, K31M] and SGTI (Schistocerca gregaria trypsin inhibitor), were determined by homonuclear NMR-spectroscopy. The molecules exhibit di€erent speci®cities towards target proteinases, where SGCI is a good chymo-trypsin inhibitor, itsmutant is apotent trypsin inhibitor, and SGTI inhibits both proteinases weakly.

11p research12 23-04-2013 33 2   Download

The catalytic activity of phenylalanine hydroxylase (PAH, phenylalanine 4-monooxygenase EC 1.14.16.1) is regulated by three main mechanisms, i.e. substrate (L-phenylalanine, L-Phe) activation, pterin cofactor inhibition and phos-phorylation of a single serine (Ser16) residue.To address the molecular basis for the inhibition by the natural cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, its effects on the recombinant tetrameric human enzyme (wt-hPAH) was studied using three different conformational probes, i.e.

10p tumor12 20-04-2013 34 3   Download

Only 2% of the known natural products with acetylenic bonds area-alkynoates. Their polarized, conjugated triple bond is an optimal target for an enzymic hydration. Therefore they are good substrates for the enzymes involved in metabolism of acetylenic compounds, resulting in products that are suitable for bacterial growth. We isolated a Pseudomonas putida strain growing on 2-butynedioate as well as on propynoate, and determined the metabolic pathways of these two a-alkynoates.

6p tumor12 20-04-2013 28 1   Download

The nature and amount of information needed for learning a natural language, and the underlying mechanisms involved in this process, are the subject of much debate: is it possible to learn a language from usage data only, or some sort of innate knowledge and/or bias is needed to boost the process? This is a topic of interest to (psycho)linguists who study human language acquisition, as well as computational linguists who develop the knowledge sources necessary for largescale natural language processing systems. ...

1p hongphan_1 15-04-2013 66 2   Download

In a previous study we showed that natural polyamines interact in the nuclear environment with phosphate groups to form molecular aggregates [nuclear aggregates of polyamines (NAPs)] with estimated molecular mass values of 8000, 4800 and 1000 Da. NAPs were found to interact with genomic DNA, influence its conformation and interfere with the action of nucleases.

11p fptmusic 11-04-2013 43 2   Download

Aedes aegyptikynurenine aminotransferase (AeKAT) catalyzes the irrevers-ible transamination of kynurenine to kynurenic acid, the natural antagonist of NMDA and 7-nicotinic acetycholine receptors. Here, we report the crys-tal structure of AeKAT in its PMP and PLP forms at 1.90 and 1.55 A ˚ , respectively. The structure was solved by a combination of single-wave-length anomalous dispersion and molecular replacement approaches.

9p awards 06-04-2013 38 2   Download

a-Crystallin is the principal lens protein which, in addition to its structural role, also acts as a molecular chaperone, to prevent aggregation and preci-pitation of other lens proteins. One of its two subunits,aB-crystallin, is also expressed in many nonlenticular tissues, and a natural missense muta-tion, R120G, has been associated with cataract and desmin-related myopa-

14p awards 05-04-2013 44 2   Download

With the amount of genetic information available, a lot of attention has focused on systems biology, in particular biomolecular interactions. Con-sidering the huge number of such interactions, and their often weak and transient nature, conventional experimental methods such as X-ray crystal-lography and NMR spectroscopy are not sufficient to gain structural insight into these. A wealth of biochemical and⁄or biophysical data can, however, readily be obtained for biomolecular complexes.

20p awards 05-04-2013 46 3   Download

Cellular functions are ultimately linked to metabolic fluxes brought about by thousands of chemical reactions and transport processes. The synthesisof theunderlying enzymes and membrane transporters causes the cell a certain
effort of energyandexternal resources.Considering that those cells should have had a selection advantage during natural evo-lution that enabled them to fulfil vital functions (such as growth, defence against toxic compounds, repair of DNA alterations, etc.)

18p dell39 03-04-2013 34 5   Download

Using solution NMR spectroscopy, three-dimensional structures have been obtained for an 18-residue synthetic polypeptide fragment of 18.5 kDa myelin basic protein (MBP, human residues Q81–T98) under three condi-tions emulating the protein’s natural environment in the myelin membrane to varying degrees: (a) an aqueous solution (100 mmKCl pH 6.5), (b) a mixture of trifluoroethanol (TFE-d2) and water (30 : 70% v⁄v), and (c) a dispersion of 100 mm dodecylphosphocholine (DPC-d38 , 1 : 100 pro-tein⁄lipid molar ratio) micelles....

14p dell39 27-03-2013 39 3   Download

A versatile software tool,virtualmslab, is presented that can perform advanced complex virtual proteomic experiments with mass spectrometric analyses to assist in the characterization of proteins. The virtual experimen-tal results allow rapid, flexible and convenient exploration of sample prepar-ation strategies and are used to generate MS reference databases that can be matched with the real MS data obtained from the equivalent real experi-ments.

11p dell39 27-03-2013 35 3   Download

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including humans, melatonin is synthes-ized primarily in the pineal gland and is regulated by the environmental light⁄dark cycle via the suprachiasmatic nucleus.

26p inspiron33 25-03-2013 37 4   Download