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Landscape genetics
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Meningiomas are among the most common primary tumors of the central nervous system. Previous research into the meningioma histological appearance, genetic markers, transcriptome and epigenetic landscape has revealed that benign meningiomas significantly differ in their glucose metabolism compared to aggressive lesions.
10p
vishanshan
27-06-2024
2
1
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Hepatocellular carcinoma (HCC) genomic research has discovered actionable genetic changes that might guide treatment decisions and clinical trials. Nonetheless, due to a lack of large-scale multicenter clinical validation, these putative targets have not been converted into patient survival advantages.
12p
vikoch
27-06-2024
1
1
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Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response to viral infection provides insight into disease etiology and therapeutic opportunities.
18p
vibransone
28-03-2024
2
2
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Alterations in genetic and epigenetic landscapes are known to contribute to the development of different types of cancer. However, the mechanistic links between transcription factors and the epigenome which coordinate the deregulation of gene networks during cell transformation are largely unknown.
16p
vioraclene
31-03-2024
2
2
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Multimorbidities greatly increase the global health burdens, but the landscapes of their genetic risks have not been systematically investigated. Methods: We used the hospital inpatient data of 385,335 patients in the UK Biobank to investigate the multimorbid relations among 439 common diseases. Post-GWAS analyses were performed to identify multimorbidity shared genetic risks at the genomic loci, network, as well as overall genetic architecture levels.
20p
vibransone
28-03-2024
4
1
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Cancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective.
21p
vibransone
28-03-2024
5
2
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The Colombian population, as well as those in other Latin American regions, arose from a recent tricontinental admixture among Native Americans, Spanish invaders, and enslaved Africans, all of whom passed through a population bottleneck due to widespread infectious diseases that left small isolated local settlements.
22p
viellison
28-03-2024
4
2
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Next-generation sequencing (NGS) has significantly transformed the landscape of identifying diseasecausing genes associated with genetic disorders. However, a substantial portion of sequenced patients remains undiagnosed.
22p
vicwell
29-02-2024
4
2
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Estrogen receptor-positive and progesterone receptor-negative (ER+/PR-) breast cancer comprise a special type. More than 10% breast cancer patients belonged to ER+/PR-. In this study, we identified the clinical and genetic characteristics of ER+/PR- breast cancer patients in China. Distinct PR statuses indicated different biological processes of ER+breast cancer and survival outcomes. Future treatment strategies may need to be tailored for ER+/PR- patients.
11p
vileonardodavinci
23-12-2023
6
2
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The Deo Ca Special Use Forest also plays a very important role in maintaining ecological balance, environment and landscape protection, climate regulation for the region, watershed protection, genetic resources, and biodiversity protection of tropical forest flora and fauna.
9p
vispacex
16-11-2023
2
2
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The aim of the study was to comprehensively explore the genetic susceptibility correlations among diseases and traits from large-scale individual genotype data. The study suggests that common genetic background exists between diseases and traits with epidemiologic associations. The GRS correlation approach provides a rich source of candidate associations among diseases and traits from the genetic perspective, warranting further epidemiologic studies.
6p
visteverogers
24-06-2023
4
2
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The ancient Silk Road has been a trading route between Europe and Central Asia from the 2nd century BCE to the 15th century CE. While most populations on this route have been characterized, the genetic background of others remains poorly understood, and little is known about past migration patterns.
10p
vinarcissa
21-03-2023
4
1
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Connectivity among jaguar (Panthera onca) populations will ensure natural gene flow and the longterm survival of the species throughout its range. Jaguar conservation efforts have focused primarily on connecting suitable habitat in a broad-scale. Accelerated habitat reduction, human-wildlife conflict, limited funding, and the complexity of jaguar behaviour have proven challenging to maintain connectivity between populations effectively.
13p
vihagrid
30-01-2023
3
3
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Constraints in migratory capabilities, such as the disruption of gene flow and genetic connectivity caused by habitat fragmentation, are known to affect genetic diversity and the long-term persistence of populations. Although negative population trends due to ongoing forest loss are widespread, the consequence of habitat fragmentation on genetic diversity, gene flow and genetic structure has rarely been investigated in Bornean small mammals.
13p
vihagrid
30-01-2023
8
3
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The transcription factor reservoir and chromatin landscape in activated plasmacytoid dendritic cells
Transcription factors (TFs) control gene expression by direct binding to regulatory regions of target genes but also by impacting chromatin landscapes and modulating DNA accessibility for other TFs. In recent years several TFs have been defined that control cell fate decisions and effector functions in the immune system.
20p
vihagrid
30-01-2023
6
3
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Belonging to the protein arginine methyltransferase (PRMT) family, the enzyme encoded by coactivator-associated arginine methyltransferase 1 (CARM1) catalyzes the methylation of protein arginine residues, especially acts on histones and other chromatin-related proteins, which is essential in regulating gene expression.
21p
vihagrid
30-01-2023
10
3
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Describing how genetic history shapes the pattern of medically relevant variants could improve the understanding of how specific loci interact with each other and affect diseases and traits prevalence. The Qatari population is characterized by a complex history of admixture and substructure, and the study of its population genomic features would provide valuable insights into the genetic landscape of functional variants.
10p
vihagrid
30-01-2023
10
3
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The genetic landscape of pancreatic head ductal adenocarcinoma in China and prognosis stratification
Pancreatic ductal adenocarcinoma (PDAC) is the major subtype of pancreatic cancer and head PDACs show distinct characteristics from body/tail PDACs. With limited studies based on Asian population, the mutational landscape of Asian PDAC remains unclear.
12p
vikolindagrabar
27-07-2022
5
2
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Bread wheat is one of the most important and broadly studied crops. However, due to the complexity of its genome and incomplete genome collection of wild populations, the bread wheat genome landscape and domestication history remain elusive.
16p
vigalileogalilei
27-02-2022
11
1
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Sequence exchange between homologous chromosomes through crossing over and gene conversion is highly conserved among eukaryotes, contributing to genome stability and genetic diversity. A lack of recombination limits breeding efforts in crops; therefore, increasing recombination rates can reduce linkage drag and generate new genetic combinations.
16p
vigalileogalilei
27-02-2022
11
1
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