Latent tuberculosis infection

Therapeutic blockade of tumour necrosis factor alpha (anti-TNF-α) is the mainstay treatment of several rheumatologic diseases. They are unfrequently associated with opportunistic infections and latent tuberculosis (TB) screening is paramount before immunosuppression. A 62-year-old man with psoriatic arthritis was under treatment with adalimumab for over 5 years.

4p viintuit 26-09-2023 2 0   Download

Latent tuberculosis infection is attributed in part to the existence of Mycobacterium tuberculosis in a persistent non-replicating dormant state that is associated with tolerance to host defence mechanisms and antibiotics.

13p viansan2711 30-07-2021 11 1   Download

A study of latent tuberculosis infection (LTBI) burden by chest roentgenography (CXR) with reference to interferon-gamma release assay (IGRA) is still lacking in rheumatic patients of an intermediate tuberculosis burden area.

7p vimichigan2711 26-03-2021 10 1   Download

One forth whole-world population is infected with Mycobacterium tuberculosis (Mtb), but 90% of them are asymptotic latent infection without any symptoms but positive result in IFN-γ release assay. There is lack of ideal strategy to distinguish active tuberculosis (TB) and latent tuberculosis infection (LTBI).

12p vimichigan2711 26-03-2021 6 1   Download

Tuberculosis (TB) is a serious infectious disease in that 90 % of those latently infected with Mycobacterium tuberculosis present no symptoms, but possess a 10 % lifetime chance of developing active TB. To prevent the spread of the disease, early diagnosis is crucial.

13p vioklahoma2711 19-11-2020 10 2   Download

Health Care Workers (HCWs) are vulnerable to tuberculosis exposure. Non availability of a reliable test has resulted in underestimation of latent tuberculosis infection (LTBI) among HCWs. The aim is to detect the rate of LTBI among nursing and medical students, Compare Interferon Gamma Release Assay (IGRA) and Tuberculin Skin Test (TST), Detect conversions and reversions.

9p trinhthamhodang1215 23-09-2020 16 1   Download

The association between tuberculosis and HIV presents an immediate and grave public health and socioeconomic threat, particularly in the developing world. The interaction of TB with HIV is two-folded, with TB being the leading cause of death among HIV infected, and HIV infection being the most potent risk factor for a latent TB infection to convert to active disease. The study was conducted on patients diagnosed with pulmonary and extra pulmonary tuberculosis, who were admitted in the wards of National Institute of Tuberculosis & Respiratory diseases (NITRD), New Delhi.

11p trinhthamhodang7 31-08-2020 11 2   Download

Tuberculosis is the leading cause of death due to bacterial infections worldwide, mainly caused by Mycobacterium tuberculosis. The antigen 85 complex comprises a set of major secreted proteins of M. tuberculosis, which are potential biomarkers for diagnostic.

16p viuchiha2711 21-04-2020 12 1   Download

Outline of Tuberculosis - An update for Primary care physicians: Epidemiology of tuberculosis; diagnosis and treatment of latent tuberculosis infection (LTBI); diagnosis of pulmonary tuberculosis, including new diagnostics; Overview of tuberculosis treatment.

31p tuoihaimuoi32 17-06-2014 47 2   Download

Mycobacterium tuberculosisheat shock protein 16.3 (MTB HSP 16.3) accumulates as the dominant protein in the latent stationary phase of tuberculosis infection. MTB HSP 16.3 displays several characteristics of small heat shock proteins (sHsps): its expression is increased in response to stress, it protects against protein aggregationin vitro, and it contains thecoreÔa-crystallinÕdomainfound inall sHsps.

8p research12 23-04-2013 30 1   Download

Data are rapidly accumulating from all over the world regarding the efficacy of standardized treatment regimens for drug-sensitive, drug-resistant TB and latent TB infection. While we are facing the menace of multi drug-resistant TB [MDR-TB], extensively drug-resistant tuberculosis [XDR­ TB] has emerged threatening to undermine global efforts at TB control. Hence we have included chapters to cover all aspects of the diagnosis and management of MDR TB. This book will cover all these developments in great detail....

500p haiduong_1 15-04-2013 117 10   Download

decrease the burden of tuberculosis for people living with hiv. Countries should integrate “the Three I’s” into services for people living with HIV, namely: intensified case finding for active tuberculosis in people living with HIV; isoniazid preventive therapy in individuals with latent tuberculosis to prevent progression to active disease; and infection control in order to minimize transmission of tuberculosis. provide comprehensive care and support for people living with hiv.

37p nhamnhiqa 01-03-2013 50 1   Download

Despite the dramatic decline in the number of reported cases of tuberculosis (TB) in New York City, many New Yorkers remain at high risk for developing active tuberculosis disease, once infected with Mycobacterium tuberculosis. Groups at especially high risk include contacts of persons with active tuberculosis, HIV-infected persons, individuals with certain predisposing medical conditions, and recent immigrants from countries with high rates of TB.

25p taisaocothedung 12-01-2013 73 5   Download

Tuberculosis (TB) remains a worldwide health threat. One-third of the world’s population is currently infected with Mycobacterium tuberculosis that results in active or latent infection. TB causes nearly 1.8 million deaths annually (Doherty et al., 2009). Because of the increasing mobility of the population, the changing environment, and the biology of bacilli, the prevalence of TB is higher in China. Epidemiological studies indicate that only 5 to 10% of people infected with M. tuberculosis develop active TB (van Crevel et al.

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Tuberculosis is transmitted from person to person by respiratory droplets. Although some people develop active tuberculosis disease after infection, almost all tuberculosis infections are asymptomatic and remain latent. Latent tuberculosis infection (LTBI) itself progresses to active disease in approximately 5% to 10% of infected persons. The rate of progression is much greater in immunocompromised individuals. The estimated 2 billion people living with LTBI represent a vast reservoir of potential cases of tuberculosis around the world.

26p taisaocothedung 12-01-2013 41 2   Download

There is reason to expect strong genetic influences on the risk of developing active pulmonary tuberculosis (TB) among latently infected individuals. Many of the genome wide linkage and association studies (GWAS) to date have been conducted on African populations. In order to identify additional targets in genetically dissimilar populations, and to enhance our understanding of this disease, we performed a multi-stage GWAS in a Southeast Asian cohort from Indonesia. Methods: In stage 1, we used the Affymetrix 100 K SNP GeneChip marker set to genotype 259 Indonesian samples.

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Small samples and study area covering only 2 DOTS centers are some of the study limitations. Other limitations include exclusion of testing for latent TB infection (LTBI). This was as a result of shortcomings associated with use of the only available diagnostic tool- Tuberculin (Mantoux) skin test (TST). These include invasive nature of the test, the need for the patient to come back for follow up TST reading, cross-reactivity with environmental mycobacteria and previous BCG vaccination.

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Several explanations may account for the absence of an initial steep decline in incidence rates. First, the proportion of immigrants who were recently infected or reinfected may already have been low at the time of immigration. Next, the risk of reactivation of latent tuberculosis infection in these immigrants may have been higher than previously modeled in white nonimmigrant populations (8,9).

4p taisaocothedung 12-01-2013 40 2   Download

In many industrialized countries, an increasing proportion of tuberculosis patients are immigrants. Immigrants account for 50% of the incidence in the Netherlands (12). Control policies with regard to immigrant tuberculosis usually rely on chest x-ray screening and treatment of active tuberculosis. A supplemental approach, recommended by the Institute of Medicine (14), is to conduct tuberculin skin testing and to apply preventive treatment of latent infections.

5p taisaocothedung 12-01-2013 40 1   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Results of five-year systematic screening for latent tuberculosis infection in healthcare workers in Portugal

7p panasonic09 13-01-2012 46 2   Download