Limits of detection

Esophageal cancer (EC) is a deadly disease with limited therapeutic options. Although circulating tumor DNA (ctDNA) could be a promising tool in this regard, the availiable evidence is limited. We performed a systematic review and meta-analysis to summarize the clinical applicability of the next-generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR) technology on the ctDNA detection of the EC and listed the current challenges.

12p vikoch 27-06-2024 0 0   Download

This paper addresses the challenge of fault detection in Wireless Sensor Networks (WSNs), commonly used in fields like environmental monitoring and healthcare. WSNs, prone to various faults due to their deployment in unpredictable environments, require effective solutions for fault detection. Traditional machine learning approaches show limitations such as unsuitability for streaming data and the detection of a single fault type.

10p visergeyne 18-06-2024 1 0   Download

State-of-the art research on conventional microwave substrates reveals limitations of restricted flexibility, poor adaptability to irregular surfaces, and reduced effectiveness in complex sensing environments, leading to the development of a flexible microwave substrate using Co–Ca ferrite for feasible applications in detecting industrial chemicals.

15p visergeyne 18-06-2024 0 0   Download

This study addresses the limitations of the current Vessel Traffic Service (VTS) system in monitoring and ensuring navigational safety on the Cai Mep-Thi Vai channel, a crucial waterway in Vietnam's maritime transport system. This research aims to propose solutions to improve the target detection capability of the VTS system in this area.

9p vijaychest 16-05-2024 2 1   Download

The synthesis of the UiO-66/rGO material involved combining UiO-66 with reduced graphene oxide (rGO). This resulting composite found application in the electrochemical determination of salbutamol (SAL) through modification of a glassy-carbon electrode (GCE) with UiO-66/rGO. Differential pulse voltammetry served as the chosen technique, offering a wide linear range spanning 1–160 μM and demonstrating a low limit of detection at 0.84 μM

11p dianmotminh02 03-05-2024 2 1   Download

Detection of nitroaromatic explosives (NAEs) is very important in terms of national security as well as the damage they cause to living things and the environment. The precision detection of these is a very important issue to reduce their harmful effects and take the necessary precautions. Electron-rich polyaromatic fluorescent materials are highly sensitive and selective in the detection of NAEs in terms of their fluorometric quenching abilities.

11p dianmotminh02 03-05-2024 2 1   Download

The plasmon characterization of AgNS on paper was systematically investigated by the diffuse reflectance spectroscopy. The fabricated paper-based SERS substrates were used to detect melamine in an aqueous solution and to determine the influence of type RAs on the enhancement factor (EF) and signal uniformity of SERS substrates. Among the four types of RAs, the SERS substrates used NaBH4 have the highest SERS signal with the limit of detection of 10-8 M for melamine and the EF = 2.3 × 109 .

9p dianmotminh02 03-05-2024 4 1   Download

In this study, we present the experimental evidence demonstrating the utility of electrical double layer (EDL)-induced ion accumulation, using sodium (Na+) ion in water as a model substance, on a negatively charged nanostructured surface, specifically thermally grown silicon dioxide (SiO2). This novel approach, termed Ion Surface Accumulation (ISA), aims to enhance the performance of nanostructured porous silicon (PSi) interferometers in optical refractometric applications.

11p dianmotminh02 03-05-2024 7 1   Download

Pancreatic cancer is an aggressive cancer with dismal prognosis, urgently necessitating better biomarkers to improve therapeutic options and early diagnosis. Traditional approaches of biomarker detection that consider only one aspect of the biological continuum like gene expression alone are limited in their scope and lack robustness in identifying the key regulators of the disease.

20p vioraclene 31-03-2024 5 1   Download

Identifying the complete repertoire of genes that drive cancer in individual patients is crucial for precision oncology. Most established methods identify driver genes that are recurrently altered across patient cohorts. However, mapping these genes back to patients leaves a sizeable fraction with few or no drivers, hindering our understanding of cancer mechanisms and limiting the choice of therapeutic interventions.

14p vibransone 28-03-2024 3 2   Download

Structural variants (SVs) are implicated in the etiology of Mendelian diseases but have been systematically underascertained owing to sequencing technology limitations. Long-read sequencing enables comprehensive detection of SVs, but approaches for prioritization of candidate SVs are needed.

13p viellison 28-03-2024 4 1   Download

Exome sequencing (ES) is becoming more widely available in prenatal diagnosis. However, data on its clinical utility and integration into clinical management remain limited in practice. Herein, we report our experience implementing prenatal ES (pES) in a large cohort of fetuses with anomalies detected by ultrasonography using a hospital-based in-house multidisciplinary team (MDT) facilitated by a three-step genotype-driven followed by phenotype-driven analysis framework.

20p viellison 28-03-2024 5 2   Download

The deregulation of microRNA-140 (miRNA-140) has been reported to be involved in the human pathogenesis of Osteoarthritis (OA). However, in Vietnam, to our knowledge, there is a limited study of evaluation of a miRNA-140 expression. The commercial kits for the quantitation of miRNA-140 are more expensive.

7p vibego 02-02-2024 1 0   Download

This study aimed to validate a procedure for the quantification of verbascoside in the root of Rehmannia glutinosa varieties 19 by high performance liquid chromatography (HPLC) to serve the assessment of medicinal quality.

8p vibego 02-02-2024 1 0   Download

This study overcomes the above limitation. At the noise pixel detection step, the algorithm uses an adaptively sized window to help distinguish the noise candidate points as real noise pixels or texture pixels based on the observation that the noise pixels are usually isolated pixels, whose value changes suddenly compared to the surrounding values.

8p vigrab 02-02-2024 6 2   Download

Ebook "Molecular techniques in food biology: Safety, biotechnology, authenticity and traceability" explores all aspects of microbe-food interactions, especially as they pertain to food safety. Traditional morphological, physiological, and biochemical techniques for the detection, differentiation, and identification of microorganisms have severe limitations. As an alternative, many of those responsible for monitoring food safety are turning to molecular tools for identifying foodborne microorganisms.

475p lamquandat 28-12-2023 8 2   Download

Part 1 book "Molecular diagnostic PCR handbook" includes content: Background; PCR – the basic reaction; amplicon detection, analysis and PCR evaluation; limitations and troubleshooting, specific types of PCR assays.

118p oursky06 17-10-2023 5 1   Download

Outbreaks of the Southern rice black-streaked dwarf virus (SRBSDV) have caused significant losses in many rice-growing areas in Vietnam, especially in both North and Central Vietnam in recent years. To detect the virus, traditional reverse transcription polymerase chain reaction (RT-PCR) methodology and immunoassays are currently employed. RT-PCR is accurate but requires expensive chemicals and instruments, as well as complex procedures that limit its applicability for field tests.

8p viengels 25-08-2023 5 2   Download

Automatic crack detection on road surfaces is an important task for supporting the quality control of road infrastructure in transportation. Various methods have been proposed for crack segmentation, but their accuracy is still limited. To improve the effectiveness of crack detection, we propose the Swin Transformer-V2 UNET for Crack Segmentation Network model (STUCNet) for crack recognition.

15p viengels 25-08-2023 5 5   Download

A portable and simple Raman scattering and photoluminescence spectroscopy system was set up for sensitive and rapid determination of nitrate/nitrite at low concentrations in water samples. The SERS (Surface Enhanced Raman Scattering) e active Ag/ITO substrates were prepared and employed to obtain the enhanced Raman scattering light from the sample.

6p viberbers 09-08-2023 3 3   Download