Link discovery

Ebook "Potcakes: Dog ownership in New Providence, the Bahamas" draws the threads together from previous sections to show how all members of society, dog owners, non-dog owners, and the authorities, need to work together in order for the dog population to be controlled and dog welfare enhanced.

219p dongmelo 27-05-2024 6 3   Download

Ebook "Handbook of industrial cell culture: Mammalian, microbial, and plant cells" attempts to link these common approaches, while also delineating those specific aspects of cell types, to give the reader not only an overview of the best current practices, but also of today’s evolving technologies, with examples of both their practical applications and their future potential.

548p dongmelo 27-05-2024 5 3   Download

Colorectal adenocarcinomas are characterized by abnormal mitochondrial DNA (mtDNA) copy number and genomic instability, but a molecular interaction between mitochondrial and nuclear genome remains unknown. Here we report the discovery of increased copies of nuclear mtDNA (NUMT) in colorectal adenocarcinomas, which supports link between mtDNA and genomic instability in the nucleus.

15p vioraclene 31-03-2024 5 1   Download

Lecture Microprocessor (for Embedded Systems) - Chapter 4: Introduction to STM32 MCUs. This lesson provides students with content about: introduction to STM32; tool-chain for STM32; the STM32F407/411 discovery board; ST-link driver installation & firmware upgrade; STM32CubeMX installation; Keil MDK-5 setup for ARM Cortex-M based MCUs;...

25p nguyetthuongvophong1010 04-03-2024 9 1   Download

Ebook "Urea transporters (Subcellular biochemistry, Volume 73)" offers a state-of-the-art report on recent discoveries concerning urea transport and where the field is going. It mainly focuses on advances made over the past 20 years on the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of urea transport in mammalian cell membranes.

267p manmanthanhla0201 26-02-2024 8 1   Download

Ebook "Evolution that anyone can understand" discovery of the link between smoking and lung cancer and heart disease was not received well by the tobacco industry, and the link between global climate change and fossil fuel use has not been well received by the petroleum industry, to cite just two examples. Usually the response of those whose world has been disrupted by science is denial, often followed by attack on or ridicule of the science that has challenged them. In the long term, however, science usually turns out to be correct.

118p tachieuhoa 28-01-2024 8 2   Download

The goal of this work is to map Unified Medical Language System (UMLS) concepts to DBpedia resources using widely accepted ontology relations from the Simple Knowledge Organization System (skos:exactMatch, skos:closeMatch) and from the Resource Description Framework Schema (rdfs:seeAlso), as a result of which a complete mapping from UMLS (UMLS 2016AA) to DBpedia (DBpedia 2015-10) is made publicly available that includes 221 690 skos:exactMatch, 26 276 skos:closeMatch, and 6 784 322 rdfs:seeAlso mappings.

8p visteverogers 24-06-2023 2 2   Download

Clinical research data warehouses (RDWs) linked to genomic pipelines and open data archives are being created to support innovative, complex data-driven discoveries. The computing and storage needs of these research environments may quickly exceed the capacity of on-premises systems.

9p vighostrider 25-05-2023 5 2   Download

Peanut is one of the primary sources for vegetable oil worldwide, and enhancing oil content is the main objective in several peanut breeding programs of the world. Tightly linked markers are required for faster development of high oil content peanut varieties through genomics-assisted breeding (GAB), and association mapping is one of the promising approaches for discovery of such associated markers.

12p vihagrid 30-01-2023 7 3   Download

Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most abundant. RNA modifications play a key role in RNA folding and function and their dysregulation in humans has been linked to several diseases such as cancer, metabolic diseases or neurological disorder

10p viginny 23-12-2022 13 3   Download

Recent sequencing technologies enable joint quantification of promoters and their enhancer regions, allowing inference of enhancer–promoter links. We show that current enhancer–promoter inference methods produce a high rate of false positive links. We introduce FOCS, a new inference method, and by benchmarking against ChIAPET, HiChIP, and eQTL data show that it results in lower false discovery rates and at the same time higher inference power.

14p vimichaelfaraday 25-03-2022 13 1   Download

Massive genome sequencing data have inspired new challenges in personalized treatments and facilitated oncological drug discovery. We present a comprehensive database, My Personal Mutanome (MPM), for accelerating the development of precision cancer medicine protocols.

18p viarchimedes 26-01-2022 8 1   Download

Identifying genotype-phenotype links and causative genes from quantitative trait loci (QTL) is challenging for complex agronomically important traits. To accelerate maize gene discovery and breeding, we present the Complete-diallel design plus Unbalanced Breeding-like Inter-Cross (CUBIC) population, consisting of 1404 individuals created by extensively inter-crossing 24 widely used Chinese maize founders.

17p viarchimedes 26-01-2022 15 1   Download

Most existing methods for structural variant detection focus on discovery and genotyping of deletions, insertions, and mobile elements. Detection of balanced structural variants with no gain or loss of genomic segments, for example, inversions and translocations, is a particularly challenging task. Furthermore, there are very few algorithms to predict the insertion locus of large interspersed segmental duplications and characterize translocations.

11p viarchimedes 26-01-2022 5 0   Download

Higher fasting Growth Hormone (GH) has been associated with increased cardiovascular morbidity and mortality. Our objective was to find genetic determinants of fasting GH in order to facilitate future efforts of analyzing the association between fasting growth hormone and cardiovascular disease. A genome-wide association study (GWAS) was performed in a discovery cohort of 4134 persons (58% females; age 46–68 yrs), linking SNPs to fasting hs-GH. Fifteen SNPs were replicated in an independent cohort of 5262 persons (28.9% females; age 56–85 yrs).

9p vilarryellison 29-10-2021 11 1   Download

Copy number variations (CNVs) are large segments of the genome that are duplicated or deleted. Structural variations in the genome have been linked to many complex diseases. Similar to how genome-wide association studies (GWAS) have helped discover single-nucleotide polymorphisms linked to disease phenotypes, the extension of GWAS to CNVs has aided the discovery of structural variants associated with human traits and diseases.

9p vibeauty 23-10-2021 11 1   Download

Among naturally occurring small molecules, tRNA-derived cyclodipeptides are a class that have attracted attention for their diverse and desirable biological activities. However, no tools are available to link cyclodipeptide synthases identified within prokaryotic genome sequences to their chemical products. Consequently, it is unclear how many genetically encoded cyclodipeptides represent novel products, and which producing organisms should be targeted for discovery.

11p vibeauty 23-10-2021 7 0   Download

The growth of DNA biobanks linked to data from electronic health records (EHRs) has enabled the discovery of numerous associations between genomic variants and clinical phenotypes.

7p viansan2711 30-07-2021 16 1   Download

In the context of drug discovery, drug target interactions (DTIs) can be predicted based on observed topological features of a semantic network across the chemical and biological space. In a semantic network, the types of the nodes and links are different.

10p vioklahoma2711 19-11-2020 7 1   Download

Drug-drug interactions (DDIs) are one of the major concerns in drug discovery. Accurate prediction of potential DDIs can help to reduce unexpected interactions in the entire lifecycle of drugs, and are important for the drug safety surveillance.

12p vioklahoma2711 19-11-2020 4 0   Download