Lower respiratory infections
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The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory tract infections in humans is not well understood.
17p vibransone 28-03-2024 6 1 Download
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Antimicrobial resistance (AMR) is rising at an alarming rate and complicating the management of infectious diseases including lower respiratory tract infections (LRTI). Metagenomic next-generation sequencing (mNGS) is a recently established method for culture-independent LRTI diagnosis, but its utility for predicting AMR has remained unclear.
12p viellison 28-03-2024 2 2 Download
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To determine the nutritional status and the dietary intake of inpatient children with lower respiratory infections. Methods: This cross-sectional study was conducted in 106 children aged under 5 years admitted to the Pediatric Department of the National Lung Hospital in Hanoi, Vietnam, from August to December 2018.
10p vihennessey 26-09-2022 7 2 Download
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Whether procalcitonin (PCT) or C-reactive protein (CRP) combined with certain clinical characteristics can better distinguish viral from bacterial infections remains unclear. The aim of the study was to assess the ability of PCT or CRP combined with clinical characteristics to distinguish between viral and bacterial infections in hospitalized non-intensive care unit (ICU) adults with lower respiratory tract infection (LRTI).
7p vimackenziebezos 29-11-2021 12 1 Download
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Identifying trends of hospital admissions for respiratory diseases is crucial for public health and research to guide future clinical improvements for better outcomes. This study aims to define the trends of respiratory disease-related hospital admissions (RRHA) in England and Wales between 1999 and 2019.
10p vimackenziebezos 29-11-2021 3 1 Download
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Bacterial infection of the lower respiratory tract is believed to play a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and acute exacerbations of COPD (AECOPD).
13p vimontana2711 05-04-2021 16 1 Download
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The aim of this case–control study was to analyse the clinical characteristics of children with recurrent community-acquired pneumonia (rCAP) affecting different lung areas (DLAs) and compare them with those of children who have never experienced CAP in order to contribute to identifying the best approach to such patients.
8p vimontana2711 05-04-2021 18 2 Download
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Many patients with pneumonia and lower respiratory tract infection that could be treated as outpatients according to their clinical severity score, are in fact admitted to hospital. We investigated whether, with medical and social input, these patients could be discharged early and treated at home.
8p vimontana2711 05-04-2021 15 2 Download
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The aims of this study were to analyse the potential correlations between the risk of developing recurrent wheezing and the presence of specific polymorphisms of some genes regulating immune system function, and to study the relative importance of the associations of different viruses and genetic polymorphisms in causing recurrent episodes.
10p vimontana2711 05-04-2021 16 1 Download
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Cambodia, a lower middle-income country of about 16 million individuals in southeast Asia, endures a high burden of both tuberculosis and other lower respiratory infections. Differentiating tuberculosis from other causes of respiratory infection has important clinical implications yet may be challenging to accomplish in the absence of diagnostic microbiology facilities.
7p vimaine2711 26-03-2021 10 2 Download
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Lower respiratory tract infection (LRIs) is very common both in terms of community-acquired infection and hospital-acquired infection. Sputum and bronchoalveolar lavage fluid (BALF) are the most important specimens obtained from patients with LRI. The choice of antibiotic with which to treat LRI usually depends on the antimicrobial sensitivity of bacteria isolated from sputum and BALF.
7p vimichigan2711 26-03-2021 18 1 Download
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Diagnosis of lower respiratory tract infections (LRTI) depends on the presence of clinical, radiological and microbiological findings. Endotracheal suction aspirate (ETSA) is the commonest respiratory sample sent for culture from intubated patients. Very few studies have compared quantitative and semi-quantitative processing of ETSA cultures for LRTI diagnosis.
7p vimichigan2711 26-03-2021 11 2 Download
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Pneumocystis jirovecii pneumonia (PCP) is an opportunistic fungal infection that is associated with a high morbidity and mortality in immunocompromised individuals. In this study, we analysed the microbiome of the lower respiratory tract from critically ill intensive care unit patients with and without pneumocystosis.
8p vimaine2711 26-03-2021 12 2 Download
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Many patients with bronchiectasis have recurrent hospitalisations for infective exacerbations. Acute kidney injury (AKI) is known to be associated with increased in-hospital mortality. This study examined the frequency of AKI, associated risk-factors, and the association of AKI with in-hospital mortality among patients with bronchiectasis.
8p vimaine2711 26-03-2021 14 1 Download
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A minority of patients presenting with lower respiratory tract infection (LRTI) to their general practitioner (GP) have community-acquired pneumonia (CAP) and require antibiotic therapy. Identifying them is challenging, because of overlapping symptomatology and low diagnostic performance of chest X-ray.
9p vimaine2711 26-03-2021 6 1 Download
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Community-acquired pneumonia (CAP) is a severe infection, with high mortality. Antibiotic strategies for CAP differ across Europe. The objective of the study was to describe the epidemiology of CAP in Denmark and evaluate the prognosis of patients empirically treated with penicillin-G/V monotherapy.
9p vimaine2711 26-03-2021 7 1 Download
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The aim of the study is to isolate and speciate the different fungal pathogens from bronchial wash specimens from immunocompetent and immunocompromised patients with lower respiratory tract infections.
7p cothumenhmong9 18-01-2021 9 1 Download
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Though the declaration by the WHO of a ‘global TB emergency’ was in 1993, the emphasis has been more on adult disease. Pediatric TB was neglected, mainly due to greater challenges in diagnosis and the lower priority traditionally afforded to children by TB control programmes. As a result both research and surveillance data in the field of childhood TB have been greatly limited.
10p nguaconbaynhay8 13-10-2020 7 1 Download
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There has always been a controversy in bacteriological assessment of sputum samples in diagnosing lower respiratory tract infections (LRTIs). Commonly in the Microbiological laboratory, expectorated sputum samples are microscopically examined for diagnosing LRTIs. The study was aimed to determine the diagnostic value of sputum gram’s stain and sputum culture in Lower Respiratory Tract Infections in a tertiary care hospital.
5p nguaconbaynhay8 13-10-2020 18 3 Download
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Lower respiratory tract infections are one of the leading causes of morbidity and mortality in children worldwide. Several viruses can cause bronchiolitis. Respiratory syncytial virus (RSV), parainfluenza viruses (PIV), influenza type A, adenovirus and human metapneumovirus (HMPV) are some of the common viruses found in hospital studies. This study aimed to study the molecular diagnosis of HPMV infections by using a realtime, reverse-transcriptase PCR assay and the evaluation of its prevalence among Egyptian infants clinically diagnosed with acute viral bronchiolitis.
8p kethamoi6 29-06-2020 19 2 Download