Lung cancer

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  • Lung cancer is the leading cause of cancer death among men and women in the United States with 170,000 deaths per year. This exceeds the sum of the next three leading causes of death due to cancer: breast, colon, and prostate. There are over 1 million deaths worldwide due to lung cancer, making it truly an epidemic. Fewer than 15% achieve a 5-yr survival. The vast majority (85%) present with advanced disease, although stage I patients may have a 5-yr survival approaching 70% (1).

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  • Carcinoma of the lung is the most common cause of cancer-related death in men and women. Prognosis correlates strongly with stage of disease at presentation and to some degree with the histological subtype of the tumor. Histological classifications of lung cancer were somewhat arbitrary and a matter of convenience. However, multiple lines of differentiation are often found within a single tumor, if it is sufficiently sampled.

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  • Lung cancer is the most frequent cause of cancer deaths in both men and women in the U.S. (1). Although tobacco smoking is accepted as the number one cause of this devastating disease, our understanding of the acquired genetic changes leading to lung cancer is still rudimentary. Lung cancer is classifi ed into two major clinic-pathological groups, small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) (2). Squamous cell carcinoma, adenocarcinoma, and large cell carcinoma are the major histologic types of NSCLC....

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  • Primary lung cancer is one of the most common malignant diseases. The expression of Ciz1b appears to be limited to tumor cells, suggesting that this variant can be used as a marker for the cancer. This study is to evaluate the expression and diagnostic role of Ciz1b in lung cancer patients.

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  • Objectives: To remark on SUV of PET/CT in small-cell and non-small cell lung cancer and determine the value of PET/CT in the diagnosis of lung cancer. Subjects and methods: 58 patients diagnosed with lung cancer on PET/CT (24 patients with small cell and 34 patients with non-small cell in Oncology and Nuclear Medicine Center of Bachmai Hospital, from August 2010 to October 2015.

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  • part 1 book “fast facts - non-small-cell lung cancer” has contents: introduction, prevention and screening, diagnosis and pathological classification, staging and surgery, radiotherapy.

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  • part 2 book “fast facts - non-small-cell lung cancer” has contents: immuno-oncology, first and second-line chemotherapy in advanced nsclc, management of brain metastases, personalized treatment in advanced nsclc.

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  • (bq) “abc of lung cancer” has contents: epidemiology, risk factors and prevention, symptoms and assessment, service organisation and guidelines for referral, small-cell lung cancer, malignant pleural mesothelioma, radiotherapy for non-small cell lung cancer,… and other contents.

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  • Cordycepin, an active ingredient in the insect fungus Cordyceps militaris, is in a category of compounds that exhibit significant therapeutic activity. The aim of the present study was to investigate the effect of cordycepin on cell proliferation, apoptosis, and cell cycle in A549 human lung cancer cells.

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  • Objectives: To give a description of clinical characteristics of brain magnetic resonance image in patients with brain metastases from non-small cell lung cancer. Subjects and method: A prospective study on 104 patients with brain metastases from non-small cell lung cancer, from 2-2017 to 9-2018.

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  • Objectives: Pathological classification of lung cancer is based on the expression of immunohistochemical markers, and evaluating the characteristics of EGFR gene mutations of lung cancers. Subjects and methods: The cross-sectional, descriptive, retrospective and prospective study of 193 patients, 150 males and 43 females, who were diagnosed with lung cancers on lung tumor surgical specimens, bronchoscopy biopsies, transthoracic biopsies, and the cell blocks obtained by pleural fluid at 103 Military Hospital, from April 2014 to June 2018.

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  • Objectives: To evaluate the operation outcomes of stage I - IIIA non-small cell lung cancer patients in Hanoi Medical University Hospital. Subjects and methods: The retrospective descriptive study of 30 non-small cell lung cancer patients staged I to IIIA.

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  • Objectives: To investigate clinical, subclinical features and expression of VEGF gene in nonsmall cell lung cancer in order to accurately diagnose the disease at an earlier stage, before the disease has developed, which can lead to a worse prognosis. Subjects and methods: One hundred patients with non-small cell lung cancer and 51 healthy subjects participated in an analytical cross-sectional study with comparison group.

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  • To explore TNM stage and quantitative parameters (SUVmean, SUVmax, MTV, TLG) in small cell lung cancer patients who underwent 18F-FDG PET/CT before initial treatment. Subjects and methods: Retrospective analysis in 32 patients diagnosed with small cell lung cancer based on pathological results at the Oncology and Nuclear Medicine Department, Bachmai Hospital and 61 non-small cell lung cancer patients at 103 Military Hospital, from November 2009 to June 2019. They were underwent 18F-FDG PET/CT-scans before the treatment.

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  • Non - small cell lung cancer (NSCLC) is the largest subgroup of lung cancers, responsible for about 80% of all lung cancers. Targeted cancer therapy has opened a new window into treatment of non - small cell lung cancer. This therapy is very effective for patients who have EGFR (Epidermal growth factor receptor) activating mutations, primarily located in the tyrosine kinase domain in the form of a base - pair deletion at exon 19 (LREA deletions, accounting for about 54%) or a point mutation at exon 21 (L858R, accounting for about 43%).

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  • Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene impact a patient’s response to targeted therapy in non - small cell lung cancer (NSCLC). Detection of these mutations plays an important role in therapeutic decision - making in NSCLC. Methods: 181 paraffin - embedded tumor tissues from grade IIIB/IV NSCLC patients were screened for mutations in exons 18 to 21 of the EGFR gene, using both the direct sequencing and the Scorpion ARMS method.

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  • Lung cancer is one of the most common malignant tumors. Histone methylation was reported to regulate the expression of a variety of genes in cancer. However, comprehensive understanding of the expression profiles of histone methyltransferases and demethylases in lung cancer is still lacking.

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  • The death receptor 5 (DR5) is a member of the tumor necrosis factor receptor superfamily that can transduce the apoptosis signal in cells. This study assessed serum levels of soluble death receptor 5 (sDR5) in small-cell lung cancer (SCLC) patients compared with those in healthy controls.

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  • Hes3 is a basic helix-loop-helix factor gene, which was found to be involved in neural cell differentiation. Expression and clinicopathological significance of Hes3 in non-small cell lung cancer was not clear. In this study, we used immunohistochemistry to examine Hes3 expression in normal human lung and non-small cell lung cancer tissues.

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  • N-myc downstream regulated gene 1 (NDRG1) plays a variety of roles in human cancers. Our previous studies showed that NDRG1 expression is elevated in non-small cell lung cancer and contributes to cancer growth. However, its function in apoptosis and chemoresistance in malignant tumors, including lung cancer, is not yet fully understood.

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