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Lung repair
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Modulation of DNA damage repair in lung squamous cell carcinoma (LUSC) can result in the generation of neoantigens and heightened immunogenicity. Therefore, understanding DNA damage repair mechanisms holds significant clinical relevance for identifying targets for immunotherapy and devising therapeutic strategies.
15p
vishanshan
27-06-2024
1
1
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Ebook "Mitochondrial DNA and diseases" describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing.
233p
lucchinguyen
28-12-2023
6
2
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Part 2 book "Handbook of low-level laser therapy" includes content: Low-level laser therapy for arthritis in animal models - beneficial effect and action mechanism; low level laser therapy for lung diseases - from the bench to the bed; low level laser (light) therapy in tendon healing in in vitro and in vivo models; bone repair in animal models; transcranial low level laser (light) therapy for stroke and traumatic brain injury in animal models,... and other contents.
447p
muasambanhan02
25-12-2023
6
2
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Repair pathway genes play an important role in the development of lung cancer. The study aimed to assess the correlation between single nucleotide polymorphisms (SNPs) in DNA repair gene (GTF2H1 and RAD54L2) and the risk of lung cancer.
10p
vileonardodavinci
23-12-2023
6
2
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Lung squamous cell carcinoma (LUSC) is prone to metastasis and likely to develop resistance to chemotherapeutic drugs. DNA repair has been reported to be involved in the progression and chemoresistance of LUSC. However, the relationship between LUSC patient prognosis and DNA damage repair genes is still unclear.
14p
vialfrednobel
23-12-2023
7
4
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Radiotherapy is an important treatment for lung cancer, mainly by triggering DNA double-strand breaks to induce cell death. Blocking DNA damage repair can increase the radiosensitivity of tumor cells. Recent studies have identifed long noncoding RNAs as key regulators in DNA damage repair.
13p
vischultz
20-10-2023
5
1
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The association involving mismatch repair (MMR) genes, molecular subtype and specific immune cell group in tumor microenvironment has been focused by more recent studies. Its prognosis value in lung adenocarcinoma (LUAD) neoadjuvant chemotherapy remains elusive.
12p
visharma
20-10-2023
3
2
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Part 1 book "Robbins essential pathology" includes content: Cell injury and cell death; inflammation and repair; hemodynamic disorders, thromboembolism, and shock; diseases of the immune system; neoplasia; genetic diseases; diseases of blood vessels; heart; hematopoietic and lymphoid systems; lung and upper respiratory tract.
228p
oursky05
20-09-2023
4
1
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Part 1 book "Essential pathology" includes content: Cell injury and cell death, inflammation and repair, hemodynamic disorders, thromboembolism, and shock, diseases of the immune system, neoplasia, genetic diseases, diseases of blood vessels, heart, hematopoietic and lymphoid systems; lung and upper respiratory tract.
228p
oursky05
20-09-2023
3
0
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Iatrogenic tracheal ruptures are rare but life-threatening airway complications that often require surgical repair. Data on perioperative vital functions and anesthetic regimes are scarce. The goal of this study was to explore comorbidity, perioperative management, complications and outcomes of patients undergoing thoracotomy for surgical repair.
10p
vizhangzhidong
29-12-2021
12
0
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C-Kit + lung stem cells have been described in the human healthy lung. Their potential relation with smoking and/or chronic obstructive pulmonary disease (COPD) is unknown. The adult human lung contains a mixture of c-Kit+ cells, unlikely to be lung stem cells, which are independent of smoking status and/or presence of COPD.
7p
vimontana2711
05-04-2021
13
2
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Double lumen intubation and one-lung ventilation should be applied without delay in cases of traumatic main bronchial rupture. In most cases, when the patients’ vital signs have been stabilized, the repair can be performed.
5p
vimontana2711
05-04-2021
10
1
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The objectives of this study were to (1) to quantify CD45+ Collagen-1+ fibrocytes and a novel epithelial-like population of bone marrow-derived cells, which express Clara Cell Secretory Protein, in patients at the time of lung transplant and (2) to evaluate mediators that may act to recruit these cells during injury.
12p
vimontana2711
05-04-2021
11
1
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Idiopathic pulmonary fibrosis (IPF) is a progressive parenchymal lung disease of unknown aetiology and poor prognosis, characterized by altered tissue repair and fibrosis. The extracellular matrix (ECM) is a critical component in regulating cellular homeostasis and appropriate wound healing.
9p
vimontana2711
05-04-2021
8
1
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Previous studies have suggested that DNA double-strand break (DSB) repair is an important protective pathway after damage. The ataxia telangiectasia mutated (ATM) gene plays an important role in the DNA DSB repair pathway.
8p
vimaine2711
26-03-2021
7
1
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53BP1 binds to the tumor suppressor p53 and has a key role in DNA damage response and repair. Low 53BP1 expression has been associated with decreased survival in breast cancer and has been shown to interact with several prognostic factors in non-small cell lung cancer.
8p
vijisoo2711
29-09-2020
7
1
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The chemotherapy resistance of non-small cell lung cancer (NSCLC) remains a clinic challenge and is closely associated with several biomarkers including epidermal growth factor receptor (EGFR) ( Drugs 72(Suppl 1):28–36, 012.), p53 ( Med Sci Monit 11(6):HY11–HY20, 2005.) and excision repair cross complementing gene 1 (ERCC1) ( J Thorac Oncol 8(5):582–586, 2013.).
8p
vijennie2711
29-09-2020
11
0
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XPA-binding protein 2 (XAB2) interacts with Cockayne syndrome complementation group A (CSA), group B (CSB) and RNA polymerase II to initiate nucleotide excision repair. This study aims to evaluate the association of XAB2 genetic variants with the risk of non-small cell lung cancer (NSCLC) using a tagging approach.
7p
viamsterdam
18-09-2020
15
1
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Chemotherapy is an important therapeutic approach for non-small cell lung cancer (NSCLC). However, a successful long-term treatment can be prevented by the occurring of chemotherapy resistance frequently, and the molecular mechanisms of chemotherapy resistance in NSCLC remain unclear.
14p
vimoscow2711
29-08-2020
15
1
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BRCA1 is a main component of homologous recombination and induces resistance to platinum in preclinical models. It has been studied as a potential predictive marker in lung cancer. Several proteins modulate the function of BRCA1. The E3 ubiquitin ligase HERC2 facilitates the assembly of the RNF8-UBC13 complex to recruit BRCA1 to DNA damage sites.
6p
vinaypyidaw2711
26-08-2020
12
1
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