Lymphocyte activation
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Although immune cell therapy has long been used for treating solid cancer, its efficacy remains limited. Interferon (IFN)-producing killer dendritic cells (IKDCs) exhibit cytotoxicity and present antigens to relevant cells; thus, they can selectively induce tumor-associated antigen (TAA)-specific CD8 T cells and may be useful in cancer treatment.
12p vishanshan 27-06-2024 2 1 Download
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The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity.
19p vibransone 28-03-2024 5 2 Download
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NF-κB is widely involved in lymphoid malignancies; however, the functional roles and specific transcriptomes of NF-κB dimers with distinct subunit compositions have been unclear. Using combined ChIP-sequencing and microarray analyses, we determined the cistromes and target gene signatures of canonical and non-canonical NF-κB species in Hodgkin lymphoma (HL) cells.
16p vioraclene 31-03-2024 8 2 Download
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Sarcoidosis is a multisystemic granulomatous disease of unknown origin. It is characterized by abnormal activation of lymphocytes and macrophages with the formation of granulomas. Most cases have asymptomatic pulmonary involvement. In case of symptoms, they have an excellent response to glucocorticoid therapy.
6p vitiki 30-01-2024 2 2 Download
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Part 1 book "Principles of fish immunology - From cells and molecules to host protection" includes content: Anatomy of teleost fish immune structures and organs; innate immunity; adaptive immunity; cellular immune responses; lymphocytes of teleosts; fish macrophages; immunoglobulins inteleost; b-cell responses and antibody repertoires in teleost fish - from ag receptor diversity to immune memory and vaccine developm; complement activation in fish with emphasis on MBL masp; cytokines and immunity.
358p muasambanhan02 25-12-2023 3 2 Download
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Platelet distribution width (PDW), but not platelet count, was found to more comprehensively reflect platelet activity. The present study, thus, aimed to evaluate the prognostic value of PDW to lymphocyte ratio (PDWLR) in patients with hepatocellular carcinoma (HCC) following hepatectomy.
8p vileonardodavinci 23-12-2023 2 2 Download
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Lymphocyte-activation gene 3 (LAG3) is an immune checkpoint receptor; novel LAG3 immune checkpoint inhibitors (ICIs) exhibit therapeutic activity in melanoma. The role of LAG3and ICIs of LAG3 are unknown in malignant pleural mesothelioma (MPM). This study aimed to uncover the prognostic landscape of LAG3 in multiple cancers and investigate the potential of using LAG3 as an ICIs target in patients with MPM.
11p vileonardodavinci 23-12-2023 3 2 Download
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Previous assessments of peritumoral infammatory infltrate in colorectal cancer (CRC) have focused on the role of CD8+ T lymphocytes. We sought to compare the prognostic value of CD8 with downstream indicators of active immune cell function, specifically granzyme B (GZMB) and CD68 in the tumour microenvironment.
13p vialfrednobel 23-12-2023 4 3 Download
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Autologous hematopoietic stem cell transplantation therapy has been widely used in recent decades for the treatment of hematological diseases, cancer, and autoimmune diseases. In autoimmune diseases, self-activated T lymphocytes and B lymphocytes secreting antibodies against host antigens are considered to be central in the pathogenesis of the disease.
7p vispacex 13-11-2023 6 2 Download
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A Wilms’ tumor 1 (WT1) oral vaccine, Bifidobacterium longum (B. longum) 420, in which the bacterium is used as a vector for WT1 protein, triggers immune responses through cellular immunity consisting of cytotoxic T lymphocytes (CTLs) and other immunocompetent cells (e.g., helper T cells).
11p vischultz 20-10-2023 2 1 Download
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Part 1 book "Encyclopedia of immunobiology (Vol 3 - Activation of the immune system)" includes content: Adapter molecules in immune receptor signaling, immunological synapses, kinase and phosphatase effector pathways in T Cells, cellular metabolism controls lymphocyte activation and differentiation, signal Transduction by the B Cell antigen receptor,...and other contents.
308p oursky06 17-10-2023 3 2 Download
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Part 1 book "How the immune system works" includes content: An overview, the innate immune system, B cells and antibodies, the magic of antigen presentation, T cell activation, T cells at work, secondary lymphoid organs and lymphocyte trafcking.
94p oursky05 20-09-2023 2 1 Download
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Part 2 book "Basic veterinary immunology" includes content: T-Lymphocyte development, B-Cell development, T-Cell activation, B-Cell activation and differentiation, fetal and neonatal immunity, adaptive immune responses to infections and immunological memory. vaccination, immune deficiencies and immunemediated diseases, veterinary clinical laboratory immunology, the immune system and cancer
196p oursky05 20-09-2023 4 2 Download
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Part 1 book "Lippincott's illustrated reviews, immunology" includes content: The need for self recognition; antigens and receptors, barriers to infection, cells of the innate immune system, innate immune function, molecules of adaptive immunity, cells and organs, lymphocyte development, lymphocyte activation, lymphocyte effector functions, regulation of adaptive responses, generation of immune diversity - lymphocyte antigen receptors.
174p oursky05 20-09-2023 2 1 Download
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Part 2 book "Lippincott's illustrated reviews, immunology" includes content: Molecules of adaptive immunity, caells and organs, generation of immune diversity - lymphocyte antigen receptors, lymphocyte development, lymphocyte activation, lymphocyte effector functions,.... and other contents,
210p oursky05 20-09-2023 6 1 Download
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Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with diverse clinical manifestations and relapsing - remitting disease course. Nephritis is a major cause of morbidity and mortality in patients with lupus. Many clinical parameters and laboratory markers can be used to evaluate disease activity and nephritis.
7p vicaptainmarvel 21-04-2023 8 2 Download
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To study structure-function relationships of pectic polysaccharides with their immunostimulatory activity, broccoli by-products were used. Pectic polysaccharides composed by 64 mol% uronic acids, 18 mol% Ara, and 10 mol% Gal, obtained by hot water extraction, activated B lymphocytes in vitro (25–250 μg/mL).
13p vihermione 30-12-2022 44 2 Download
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Interaction of physical activity and overall immune profile is very complex and depends on the intensity, duration and frequency of undertaken physical activity, the exposure to cytomegalovirus (CMV) infection and the age-related changes in the immune system.
13p viisaacnewton 25-04-2022 8 4 Download
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Melanoma-intrinsic activated β-catenin pathway, the product of the catenin beta 1 (CTNNB1) gene, has been associated with low/absent tumor-infiltrating lymphocytes, accelerated tumor growth, metastases development, and resistance to anti-PD-L1/anti-CTLA-4 agents in mouse melanoma models.
14p vielonmusk 21-01-2022 8 0 Download
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In this study, we presented the results of immune cells expansion from peripheral blood of nine patients belonging to three types of leading cancer in Vietnam: lung, liver and gastric cancers. These cells were expanded by using BINKIT developed by Dr. Terunuma (Biotherapy Institute in Japan), which was proved to efficiently induce the number of selective cells and activate them to kill cancer cells.
11p guitaracoustic02 08-12-2021 12 1 Download