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Lysine acetylation
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Ebook "Protein acetylation: Methods and protocols" expert researchers in the field detail many of the methods which are now commonly used to study protein acetylation. These include methods and techniques for identification of protein acetylation, column- and gel electrophoresis-based approaches, computationally prediction, and the biological response to protein acetylation.
279p
dongmelo
27-05-2024
2
2
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Histone lysine acylations by short-chain fatty acids are distinct from the widely studied histone lysine acetylation in chromatin, although both modifications are regulated by primary metabolism in mammalian cells. It remains unknown whether and how histone acylation and acetylation interact to regulate gene expression in plants that have distinct regulatory pathways of primary metabolism.
14p
vigalileogalilei
27-02-2022
8
1
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H3K27ac is well recognized as a marker for active enhancers and a great indicator of enhancer activity. However, its functional impact on transcription has not been characterized. By substituting lysine 27 in histone variant H3.3 with arginine in mouse embryonic stem cells, we diminish the vast majority of H3K27ac at enhancers.
7p
viarchimedes
26-01-2022
8
0
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Precise regulation of gene expression is required for embryonic stem cell (ESC) differentiation. Transcription factor (TF) networks coordinate the balance of pluripotency and differentiation in response to extracellular and intracellular signals. Chromatin factors work alongside TFs to achieve timely regulation of gene expression for differentiation process. Our previous studies showed that a member of the Sin3a corepressor complex, Arid4b, is critical for proper mouse ESC differentiation into mesoderm and endoderm.
9p
thiencuuchu
27-11-2021
8
0
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Deep-sea hydrothermal vents are unique chemoautotrophic ecosystems with harsh conditions. Alvinocaris longirostris is one of the dominant crustacean species inhabiting in these extreme environments. It is significant to clarify mechanisms in their adaptation to the vents. Lysine acetylation has been known to play critical roles in the regulation of many cellular processes. However, its function in A. longirostris and even marine invertebrates remains elusive. Our study is the first, to our knowledge, to comprehensively investigate lysine acetylome in A. longirostris.
13p
vibeauty
23-10-2021
12
1
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Nε -Acetylation of lysine residues, a frequently occurring post-translational modification, plays important functions in regulating physiology and metabolism. However, the information of global overview of protein acetylome under nitrogen-starvation/resupply in tea (Camellia sinensis) leaves was limited. And the full function of lysine acetylated proteins of tea plants in nitrogen absorption and assimilation remains unclear.
13p
vitzuyu2711
29-09-2021
8
1
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Histone deacetylases (HDACs) are the proteins responsible for removing the acetyl group from lysine residues of core histones in chromosomes, a crucial component of gene regulation. Eleven known HDACs exist in humans and most other vertebrates. While the basic function of HDACs has been well characterized and new discoveries are still being made, the transcriptional regulation of their corresponding genes is still poorly understood.
12p
visilicon2711
20-08-2021
6
1
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Fusarium graminearum is a destructive fungal pathogen of wheat, barley and other small grain cereals. During plant infection, the pathogen produces trichothecene mycotoxin deoxynivalenol (DON), which is harmful to human and livestock. FgGCN5 encodes a GCN5 acetyltransferase.
11p
viansan2711
30-07-2021
10
1
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Fatty liver is a high incidence of perinatal disease in dairy cows caused by negative energy balance, which seriously threatens the postpartum health and milk production. It has been reported that lysine acetylation plays an important role in substance and energy metabolism.
17p
vijeeni2711
24-07-2021
9
0
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Histone modifications are critical in regulating neuronal processes. However, the impacts of individual histone modifications on learning and memory are elusive. Here, we investigated the contributions of histone H3 lysine modifications to learning and memory in Drosophila by using histone lysine-to-alanine mutants.
14p
viwyoming2711
16-12-2020
10
1
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Lysine acetylation in protein is one of the most important post-translational modifications (PTMs). It plays an important role in essential biological processes and is related to various diseases. To obtain a comprehensive understanding of regulatory mechanism of lysine acetylation, the key is to identify lysine acetylation sites.
11p
vicoachella2711
27-10-2020
8
0
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Acetylation on lysine is a widespread post-translational modification which is reversible and plays a crucial role in some biological activities. To better understand the mechanism, it is necessary to identify acetylation sites in proteins accurately.
15p
vijisoo2711
27-10-2020
7
0
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Reprogramming of energy metabolism of malignant cancer cells confers competitive advantage in growth environments with limited resources. However, not every process of cancer development is associated with competition for resources.
12p
virose2711
25-09-2020
14
1
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Targeted therapy has always been the focus in developing therapeutic approaches in cancer, especially in the treatment of acute myeloid leukemia (AML). A new small molecular inhibitor, JQ1, targeting BRD4, which recognizes the acetylated lysine residues, has been shown to induce cell cycle arrest in different cancers by inhibiting MYC oncogene.
11p
vimanila2711
29-06-2020
8
0
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Tamoxifen, an agonist of estrogen receptor, is widely prescribed for the prevention and long-term treatment of breast cancer. A side effect of tamoxifen is fatty liver, which increases the risk for non-alcoholic fatty liver disease.
10p
vienzym2711
03-04-2020
19
1
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Biotin protein ligase (BPL) catalyses the biotinylation of the biotin carboxyl carrier protein (BCCP) subunit of acetyl CoAcarboxylase and this post-translational modificationof a single lysine residue is exceptionally specific. The exact details of the protein–protein interactions involved are unclear as a BPL:BCCP complex has not yet been isolated. Moreover, detailed information is lacking on the composi-tion, biosynthesis and role of fatty acids in hyperthermo-philic organisms.
11p
tumor12
20-04-2013
32
2
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Histone H4 lysine 16 acetylation breaks the genome’s silence...
3p
thulanh20
10-11-2011
42
1
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Peptide tương tự cũng đã được tổng hợp với một nắp acetyl Hcontaining lysine N-thiết bị đầu cuối để truyền đạt một radiolabel peptide và các sản phẩm photolysis. Cleavage của photoproduct với cyanogen bromide hoặc S. aureus V8 proteinase dẫn đến sự phân tách chọn lọc của trái phiếu amide trong calmodulin polypeptide mà không có bất kỳ sự phân tách của các phối tử peptide
41p
kimku17
26-10-2011
63
6
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- Lysin acetyl salicylat (Aspégic): là dạng muối hòa tan, mỗi lọ tương đương với 0,5g aspirin. Tiêm tĩnh mạch hoặc tiêm bắp 1 -4 lọ/ngày. - Aspirin pH8: viên nén chứa 0,5 g aspirin, được bao bằng chất kháng với dịch vị, nhưng tan trong dịch ruột, ở đoạn 2 của tá t ráng, từ đó thuốc được hấp thu vào máu và bị thuỷ phân thành acid salicylic. Nồng độ tối đa trong máu đạt được sau 7 giờ, thời gian bán thải dài hơn aspirin bình thường, do đó giảm được số lần uống thuốc trong ngày,...
48p
myxaodon08
06-06-2011
212
81
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