![](images/graphics/blank.gif)
Maintaining stability
-
Genome stability is maintained by the DNA damage repair (DDR) system composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic variation (PV) in DDR genes damages function of the affected DDR genes, leading to genome instability and high risk of diseases, in particular, cancer.
17p
vishanshan
27-06-2024
2
1
Download
-
The aim of a food distribution center is to meet food supply chain chain throughout the region, avoid food scarcity, stabilize food prices and maintain price disparities thus they can be properly met. The role of food hubs is to aggregate, distribute and market food at the farmer, trader level, and to function the role of the BUMD in realizing the operation of the food distribution center.
13p
longtimenosee07
29-03-2024
6
2
Download
-
Ebook "Tetramer stability and functional regulation of tumor suppressor protein p53" presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis.
82p
coduathanh1122
27-03-2024
1
1
Download
-
In ebook "Recent developments in high pressure processing of foods" fruit processing and preservation technologies must ensure fresh-like characteristics in foods while providing an acceptable and convenient shelf life, as well as assuring safety and nutritional value. Processing technologies include a wide range of methodologies to inactivate microorganisms, improve quality and stability, and preserve and minimize changes of fresh-like characteristics in fruit.
130p
coduathanh1122
27-03-2024
2
1
Download
-
Ebook "Finance and world order: Financial fragility, systemic risk, and transnational regime" advocates the transnational regime theory, which provides an instrument for conceptualizing the internationalization of private finance and directing attention to a new way of structuring the international environment. It also advances a policy prescription for helping maintain order and stability in the global financial market.
126p
mocthanhdao0210
20-11-2023
8
5
Download
-
This is the basis and premise for making an important contribution to the successful implementation of political tasks, socio-economic development, building a strong Party and political system, maintaining political stability, promoting the great national unity bloc, social order and safety in the Central Highlands provinces in the current integration context.
8p
visharma
20-10-2023
11
3
Download
-
Telomeres are repetitive DNA sequences located at the ends of chromosomes, playing a vital role in maintaining chromosomal integrity and stability. Dysregulation of telomeres has been implicated in the develop‑ ment of various cancers, including non-small cell lung cancer (NSCLC), which is the most common type of lung cancer
10p
vioracle
29-09-2023
6
2
Download
-
When the airship moves in the air, the tail-wings play a very important role in controlling and maintaining stability. The choice of the tail-wing layout determines the design, manufacture, construction and aerodynamic shape of each type of airship. On the tail-wings extra wings, brake wings are also put to help the flight process of safety.
8p
viengels
25-08-2023
4
2
Download
-
This study also analyzed different scenarios and noticed that the total loss of the distribution decreased by increasing the number of BESS. The result reveals that with the optimum BESS size achieved, it can dramatically improve the stability of the microgrid and simultaneously maintain a high level of economic viability.
5p
vifalcon
16-05-2023
10
5
Download
-
Considering its superior photocatalytic activity and excellent chemical stability, titanium dioxide (TiO2 ) is an excellent candidate for photoelectrochemical (PEC) hydrogen production. Besides, many challenges exist ahead of improving the photoresponse of TiO2 to visible light while maintaining high photocatalytic activity.
6p
vicedric
08-02-2023
3
1
Download
-
In the current study, the effect of USP7 on pluripotency maintenance of mouse ESCs (mESCs) has been investigated with the help of cell viability assay, morphological analysis, alkaline phosphatase (ALP) staining, qPCR analysis, and Western Blotting. 600 nM P5091 application, which showed no significant toxicity in mESCs, increased the total ubiquitinated protein amount as a proof of the accomplishment of proper USP7 inhibition.
14p
lyhuyenthu
31-01-2023
8
3
Download
-
This paper presents the stability analysis of an isolated microgrid based on wind-photovoltaic-diesel hybrid energy sources with the introduction of a proposed VSG. The proposed VSG is based on a battery-supercapacitor (SC) hybrid energy storage system aiming to maintain the stability of the studied isolated microgrid under disturbance conditions.
6p
visherylsandber
04-07-2022
7
2
Download
-
Marek’s disease (MD) is a chicken neoplastic disease, which brings huge economic losses to the global poultry industry. The wild type p53, a tumor suppressor gene, plays a key role in blocking cell cycle, promoting apoptosis, and maintaining the stability of the genome. However, the mutant p53 losses its tumor inhibitory role and become an oncogene when a mutation has happened.
7p
vigandhi
23-02-2022
5
1
Download
-
CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation of TADs, the role of CTCF binding in their evolution and stability remains elusive.
19p
vielonmusk
30-01-2022
10
0
Download
-
Crystalloids are first line in fluid resuscitation therapy, however there is a lack of evidence-based recommendations on the volume to be administered. Therefore, we aimed at comparing the systemic hemodynamic and respiratory effects of volume replacement therapy with a 1:1 ratio to the historical 1:3 ratio.
9p
vampires36
30-12-2021
8
0
Download
-
To investigate the optimal dose of dexmedetomidine to maintain hemodynamic stability, prevent of cough and minimize postoperative pain for patients undergoing laparoscopic cholecystectomy.
10p
vidietmarhopp
29-12-2021
17
0
Download
-
This review examines DGC remodeling as a common denominator in diseases affecting heart function and health. Dystrophin and the DGC serve as broad cytoskeletal integrators that are critical for maintaining stability of muscle membranes. The presence of pathogenic variants in genes encoding proteins of the DGC can cause absence of the protein and/or alterations in other complex members leading to muscular dystrophies.
20p
lazzaro
30-12-2021
8
0
Download
-
The results of the physiological parameters showed that their profile changes were consistent with those of the proteome analysis. The results of the proteome and physiological parameters showed that K. candel roots could resist highsalinity stress by maintaining a normal Embden-Meyerhof-Parnas and tricarboxylic acid (EMP-TCA) pathway, increasing the activities of various antioxidant enzymes and antioxidant contents, stabilizing the cell wall structure, and accumulating secondary metabolites such as triterpenoids.
13p
thiencuuchu
27-11-2021
6
1
Download
-
The membrane maintained stability under enzymatic conditions for up to 16 days of incubation. The results confirmed tBP as a cell-friendly scaffold for hADSCs due to low cytotoxicity and its ability to support an appropriate attachment and proliferation of hADSCs. Moreover, there was an accumulation of the extracellular matrix proteoglycan in tBP seeded with hADSCs after 7 and 14 days of chondrogenic induction. COMP as a specific marker of chondrogenesis was detected after 7 days, whereas type X-a1 collagen (Col10a1) expression was stable up to day 14.
11p
thiencuuchu
27-11-2021
10
1
Download
-
Autophagy and DNA repair are two essential biological mechanisms that maintain cellular homeostasis. Impairment of these mechanisms was associated with several pathologies such as premature aging, neurodegenerative diseases, and cancer. Intrinsic or extrinsic stress stimuli (e.g., reactive oxygen species or ionizing radiation) cause DNA damage. As a biological stress response, autophagy is activated following insults that threaten DNA integrity.
18p
thiencuuchu
27-11-2021
8
1
Download