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Maturation promoting factor
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GATA1 is a key transcription factor in the GATA family, and promotes the differentiation and maturation of red blood cell, which is essential for normal hematopoiesis. Our study provides cues for further studying the roles of GATA1 gene in fish development, and suggested a potential molecular mechanism by which NP leads to abnormal development of fish embryos.
13p
vihagrid
30-01-2023
7
3
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Immature mammalian oocytes are held arrested at prophase I of meiosis by an inhibitory phosphorylation of cyclin-dependent kinase 1 (CDK1). Release from this meiotic arrest and germinal vesicle breakdown is dependent on dephosphorylation of CDK1 by the protein, cell cycle division 25B (CDC25B).
22p
viwyoming2711
16-12-2020
19
1
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MiRNA-27a has been confirmed as an important regulator in carcinogenesis and other pathological processes. Whether and how it plays a role in the laryngeal carcinoma is unknown. Methods: Mature miRNA-27a expression in laryngeal cancer was detected by qRT-PCR.
12p
vilisa271
22-09-2020
9
1
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The eukaryotic translation initiation factor (eIF) 4E, is regulated by modulating both its phosphorylation and its availability to interact with the scaffold protein, eIF4G, to form the mature eIF4F complex. Here we show that treat-ment of C2C12 myoblasts with the proteasomal inhibitor, MG132 (N-carbobenzoxyl-Leu-Leu-leucinal), resulted in an early decrease inprotein synthesis rates followed by a partial recovery, reflecting the reprogramming of translation.
16p
dell39
03-04-2013
41
2
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Tissue-type plasminogen activator (t-PA) has recently been identified as a modulator of neuronal plasticity and can initiate conversion of the pro-form of brain-derived neurotrophic factor (BDNF) into its mature form. BDNF also increases t-PA gene expression implicating t-PA as a downstream effector of BDNF function.
13p
galaxyss3
19-03-2013
63
2
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As children grow and mature, the scope of their environment predictably expands from the womb to the wider community to the broadest reach of the planet. The child’s built environment is a central factor in this progression. Both known and newly emerging diseases are linked to risk factors within the built environment, including injuries, lead poisoning, and the current epidemics of asthma and obesity. Building and land-use policies can either undermine or promote safety, health and optimal development while simultaneously preserving future resources.
8p
connhobinh
10-12-2012
57
0
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