Mature microRNAs
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The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-silencing pathways It exerts a pivotal role in microRNA maturation and activity and can modulate chromatin remodeling, transcriptional gene regulation and RNA splicing.
27p vialfrednobel 29-01-2022 8 0 Download
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MicroRNAs proceeds through the different canonical and non-canonical pathways; the most frequent of the non-canonical ones is the splicing-dependent biogenesis of mirtrons. We compare the mirtrons and nonmirtrons of human and mouse to explore how their maturation appears in the precursor structure around the miRNA.
12p vibeauty 23-10-2021 7 0 Download
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MicroRNAs (miRNAs) regulate gene expression and have been targeted as indicators of environmental/ toxicologic stressors. Using the data from our deep sequencing of miRNAs in an extensive sampling of rat tissues, we developed a database called RATEmiRs for the Rat Atlas of Tissue-specific and Enriched miRNAs to allow users to dynamically determine mature-, iso- and pre-miR expression abundance, enrichment and specificity in rat tissues and organs.
13p vitzuyu2711 29-09-2021 8 1 Download
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MicroRNAs play important roles in regulating biological processes, including organ morphogenesis and maturation. However, little is known about specific pathways regulated by miRNA during lung development. Between the canalicular and saccular stages of the developing lung several important cellular events occur, including the onset of surfactant synthesis, microvascular remodeling and structural preparation for subsequent alveolarization.
11p vimariana2711 22-12-2020 8 1 Download
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Hazels (Corylus spp.) are economically important nut-producing species in which ovule development determines seed plumpness, one of the key parameters reflecting nut quality. microRNAs (miRNAs) play important roles in RNA silencing and the post-transcriptional regulation of gene expression.
15p viwyoming2711 16-12-2020 14 2 Download
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MicroRNAs (miRNAs) are about 22 nucleotides, non-coding RNAs that affect various cellular functions, and play a regulatory role in different organisms including human. Until now, more than 2500 mature miRNAs in human have been discovered and registered, but still lack of information or algorithms to reveal the relations among miRNAs, environmental chemicals and human health.
10p vioklahoma2711 19-11-2020 12 1 Download
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Dicer is necessary for the process of mature microRNA (miRNA) formation because the Dicer enzyme cleaves pre-miRNA correctly to generate miRNA with correct seed regions. Nonetheless, the mechanism underlying the selection of a Dicer cleavage site is still not fully understood.
11p vioklahoma2711 19-11-2020 6 1 Download
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MicroRNAs (miRNAs) are small RNAs that regulate gene expression at a post-transcriptional level and are emerging as potentially important biomarkers for various disease states, including pancreatic cancer. In silicobased functional analysis of miRNAs usually consists of miRNA target prediction and functional enrichment analysis of miRNA targets.
17p vijisoo2711 27-10-2020 17 0 Download
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MiRNA-27a has been confirmed as an important regulator in carcinogenesis and other pathological processes. Whether and how it plays a role in the laryngeal carcinoma is unknown. Methods: Mature miRNA-27a expression in laryngeal cancer was detected by qRT-PCR.
12p vilisa271 22-09-2020 9 1 Download
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Cancers are commonly characterised by hypoxia and also by global reductions in the levels of mature microRNAs. We have examined the hypothesis that hypoxia might mediate this reduction through repressive effects on microRNA biogenesis proteins.
18p vilisa271 22-09-2020 10 0 Download
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MicroRNA-663a expression is downregulated in several tumors. However, its functions and mechanisms in human non-small cell lung (NSCLC) cancer remain obscure. The present study aimed to identify the expression pattern, biological roles and potential mechanisms by which miR-663a dysregulation is associated with NSCLC.
10p vinaypyidaw2711 26-08-2020 19 2 Download
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MicroRNAs (miRNAs) reportedly participate in the mesenchymal stem cell (MSC) chondrogenic differentiation regulation. We objected to examine how miR-218 regulate chondrogenic differentiation of synovium-derived MSCs (SDSCs) and the maturation of RCJ3.1C5.1 chondrocytes.
10p vihamax2711 21-04-2020 10 1 Download
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Generally, the 3¢-end of the duplex microRNA (miR) precursor (pre-miR) is known to be stable in vivo and serve as a mature form of miR. However, both the 3¢-end (miR9) and 5¢-end (miR9*) of a brain-specific miR9 have been shown to function biologically in brain development.
8p media19 06-03-2013 37 2 Download
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MicroRNAs (miRNAs) are generated from primary transcripts through sequential processing by two RNase III enzymes, Drosha and Dicer, in association with other proteins. This maturation is essential for their func-tion as post-transcriptional regulators.
8p media19 06-03-2013 25 2 Download
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The most frequent chromosomal abnormality in CLL is deletion of 13q14, being monoallelic in 76% of cases, and biallelic in 24% [13, 14, 24]. This deletion, also detected in MBL [11] occurs at a much lower frequency in multiple myeloma, DLBCL, mature T-cell lymphomas, and in several solid tumors [25-29]. A minimal deleted region (MDR) has been defined in a large number of CLL cases with monoallelic 13q14 deletion. This region contains the long non-coding RNA deleted in leukemia (DLEU)-2, and the first exon of the DLEU1 gene [30, 31].
302p wawawawawa 26-07-2012 51 4 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: microRNAs mature with help from cancer biology...
0p thulanh21 12-11-2011 34 1 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system...
16p thulanh19 05-11-2011 45 2 Download