Mechanisms

Resveratrol is a naturally occurring compound with anti-inflammatory properties. However, the protective molecular mechanisms of resveratrol against LPS-induced inflammation have not been thoroughly known. In the present study, we examined the antiinflammatory effect of resveratrol in inflammatory model using murine macrophage-like cell RAW264.7 stimulated with LPS. Resveratrol suppressed the production of inflammatory cytokines in LPS-stimulated RAW264.7 cells with the IC50 value as 17.5 ± 0.7 μM for IL-6, 14.2 ± 1.9 μM for IL-10, and 18.9 ± 0.6 μM for TNF-α.

9p xuanphongdacy06 18-09-2024 1 1   Download

Pesticides (mainly herbicides, insecticides, and fungicides) are used to chemically combat certain plants, animals, or microorganisms perceived as harmful to agriculture. Due to the fundamental similarities in all living beings, it is challenging to target unwanted species without affecting others, including humans.

16p viyoko 01-10-2024 7 1   Download

Chamaecrista pumila has empirically been used to treat inflammation-associated complications. However, the molecular mechanism and chemical components underlying the anti-inflammatory activity of this medicinal plant are poorly understood. Hence, the present study aimed to identify main bioactive compounds from the ethyl acetate fraction of C. pumila extract, which was demonstrated to possess the strongest anti-inflammatory effect in a previous study, and provide mechanistic insights into modulation of inflammatory responses by the compound of interest.

13p vihyuga 04-03-2025 1 1   Download

This paper presents the design of a lower limb exoskeleton made for the purpose of wrist joint rehabilitation. The authors use the exoskeleton structure in order to cope with the user’s upper-limb kinematics and to provide motion to the wrist joint when the arm is in any possible spatial configuration.

9p viinuzuka 28-02-2025 4 1   Download

Internal combustion engines are extensively used in various modes of transportation, including ships and cars. However, their operation generated significant noise, which can disrupt daily life and poses health risks. Prolonged exposure to noise can lead to insomnia, cardiovascular diseases, and even death, making noise pollution a growing social concern.

8p viinuzuka 28-02-2025 2 1   Download

This study evaluates the three-dimensional (3D) printing materials used in Fused Deposition Modeling (FDM) printing technology. 3D printing technology has been developing strongly, becoming an effective support tool in production and research.

11p viinuzuka 28-02-2025 1 1   Download

This study combines the integrated model to test the mechanism effects while previous studies have mostly relied on only one of the research models, namely the Theory of Reasoned Action (TRA), Theory of Planned Behavior (TPB), or Technology Acceptance Model (TAM).

13p viinuzuka 28-02-2025 5 1   Download

This article deals with optimizing the shape of a bearing plate commonly found in mechanical engineering. The verification of the suitability of the newly optimized model will be done on the basis of a static simulation of the shape using Inventor Pro 2023 software.

7p viyamanaka 06-02-2025 3 1   Download

Currently, the field of science and technology, particularly Artificial Intelligence (AI), is undergoing significant progress. AI involves the computer-based simulation of human cognitive functions. Within the realm of AI, machine learning, a specialized branch, utilizes mathematical algorithms to enhance computational capabilities.

10p viyamanaka 06-02-2025 2 2   Download

Steel pipe piles are widely used in coastal infrastructure due to their high strength and durability. This study investigated the accelerated corrosion effects on steel pipe pile materials in a simulated Nha Trang seawater environment, representing typical coastal conditions in Vietnam.

13p viyamanaka 06-02-2025 3 2   Download

Silica fume as a partial replacement for cement in high-strength concrete has been the focus of numerous studies. However, the impact of substituting cement with silica fume in concrete mixtures on the mechanical and thermal properties of high-strength concrete remains insufficiently explored.

10p viyamanaka 06-02-2025 2 2   Download

This article provides an overview of human rights; the right of grievance and denunciation; legal provisions on grievances, denunciations, and some mechanisms to ensure the exercise of the right of grievance and denunciation at present. This presents evaluative viewpoints and directions for further improvement to enhance the effectiveness of exercising these rights in practice.

10p viyamanaka 06-02-2025 2 2   Download

The article presents the current status of technological innovation in underground coal mining of Dong Bac Corporation. The primary research subject is the semi-mechanized longwall face I-6-2 at Bac Quang Loi coal mine of Company 790, Dong Bac Corporation.

10p viyamanaka 06-02-2025 2 2   Download

The results of ultrasonic wave propagation experiments indicated that the presence of steel fibers at a 2% content increased the time of wave propagation. On the other hand, curing conditions, specimen maintenance time, and transmission path distance affected the ultrasonic wave propagation time in high-strength concrete.

11p viyamanaka 06-02-2025 2 2   Download

This article examines the use of theme in English mechanical engineering (ME) discourse from systemic functional linguistics (SFL) perspective developed by Halliday and other systemists.

8p tuetuebinhan000 23-01-2025 4 1   Download

With firm-wide big data analytics capability growing rapidly, academics and practitioners have been considering the mechanism through which big data analytics capability can leverage innovation capability. This article analyzes the influence of big data analytics capability on both two types of innovation capability: incremental and radical, with the mediating role of total market orientation.

9p tuetuebinhan000 23-01-2025 2 2   Download

The application of hydro-mechanical transmissions is recently the trend in agricultural vehicles where a continuously variable transmission ratio has advantages. Hydro-mechanical transmissions provide efficient power transfer while maneuverability is still maintained, and therefore, fuel efficiency is enhanced.

11p tuetuebinhan000 23-01-2025 4 2   Download

This experiment aimed to synthesize isoamyl acetate and understand preparing ester’s mechanism. The test compounds underwent reflux, distillation, extraction and vacuum filtration. Through an acid, acetic acid could serve as a substrate. This could easily be attacked by isoamyl alcohol, thus producing isoamyl acetate.

4p thanhtrinhqc 23-08-2014 57 7   Download

Bone tissue, a vital component for self-healing. This inherent regenerative capacity enables bones to repair themselves following injury or damage. Understanding the mechanisms behind bone tissue self-healing is of great significance in the field of medical research and has implications for the development of novel therapeutic approaches.

7p vinara 11-01-2025 2 1   Download

Nowadays, there are many factors causing the decrease of male reproductive function such as diet, routine, chemical, ... But some of them have not been paid appropriate attention to, especially the use of paracetamol, which has a significant negative effect on the reproductive process. In this study, we will summarize the results of several studies on the harmful effects of prolonged high-dose use of paracetamol on sperm number, quality, portability and testicular morphology in experimental animals and humans.

15p vinara 11-01-2025 4 1   Download