Medical reversal
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Resistance to immune checkpoint inhibitors (ICIs) represents a major unmet medical need in non-small cell lung cancer (NSCLC) patients. Vascular endothelial growth factor (VEGF) inhibition may reverse a suppressive microenvironment and recover sensitivity to subsequent ICIs.
10p vikoch 27-06-2024 1 1 Download
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The purpose of this paper is to identify factors increasing the waiting time of EMS and prove the need to implement recommendations given on the reverse side of the first aid alert sheet for the citizens after calling an ambulance. The paper analyzes operation of Vladivostok EMS during 2016 – 2018 based on the data of the annual statistics report.
6p longtimenosee09 08-04-2024 10 2 Download
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Cerebral venous thrombosis is a rare form of venous stroke with diverse clinical manifestations. Wordfinding difficulty (anomia) is rarely reported in patients with cerebral venous thrombosis.
4p vigojek 02-02-2024 3 1 Download
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Treatment of hepatitis C infection has evolved dramatically since 2011. Previous conventional therapy with interferon and ribavirin used to have a low sustained virological response rate of less than 40%. In the new directacting antiviral therapy era, a sustained virological response can be achieved in more than 90% of cases.
4p vilazada 31-01-2024 5 2 Download
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Extracorporeal membrane oxygenation (ECMO) is an effective cardiopulmonary support therapy, which can provide temporary cardiopulmonary support for critically ill patients whose condition cannot be reversed by conventional therapy.
5p vilazada 31-01-2024 4 2 Download
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Metformin is commonly used for the treatment of type 2 diabetes mellitus. Its multiple advantages include low risk of hypoglycemia, weight neutrality, low cost, and cardioprotective and anti-inflammatory effects. Renal insufficiency is one of the contraindications for its use.
5p vitiki 30-01-2024 4 2 Download
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Hypospadias is one of the most prevalent urogenital malformations in clinic. However, some hypospadias may have a more complex disorder of sex development. Usually, hypospadias in these patients is severe.
3p vitiki 30-01-2024 3 2 Download
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Mild encephalitis/encephalopathy with reversible splenial lesion is a clinical-radiological entity found to occur in the setting of an acute systemic inflammatory state with isolated lesions of the splenium of the corpus callosum and mild encephalopathy.
6p vitiki 30-01-2024 4 2 Download
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Insulinomas are rare neuroendocrine tumors that typically present with hypoglycemic crises. Peripheral neuropathy is an uncommon complication of insulinoma. Most clinicians expect peripheral neuropathy symptoms to reverse completely after the insulin-secreting tumor is resected, but this may be a misassumption.
10p vitiki 30-01-2024 4 2 Download
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In cases with injuries to the shoulder region, the combination of acromioclavicular joint dislocation, reverse Hill–Sachs lesion, and proximal humeral fracture is a very rare condition.
4p vitiki 30-01-2024 2 2 Download
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Intrauterine devices are a widely used method of contraception worldwide. These devices are reliable, cost-effective, long-acting, and reversible. Their placement in the uterus is usually simple and safe. Forgotten IUDs carry some complications and can adversely affect the health of women. Therefore, appropriate counseling during insertion and timely removal are crucial.
3p vitiki 30-01-2024 3 2 Download
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Cervical epidural hematoma (CEH) is defined as a collection of blood in the suprameningeal space. Mechanisms of this rare pathology include spontaneous, postsurgical, and traumatic as the main subtypes. This unique case of traumatic CEH represents an even smaller subset of these cases. Management varies by symptom presentation, mechanism of injury, and other contraindications.
6p vitiki 30-01-2024 3 2 Download
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The BRCA2 gene is a well-known tumor suppressor gene implicated in breast and ovarian cancers. BRCA1/2 mutations can be sensitive to poly ADP-ribose polymerase (PARP) inhibitors such as olaparib. However, some of these patients develop resistance to this treatment and an essential factor contributing to acquired insensitivity is the occurrence of reversion mutations in the BRCA1/2 genes.
5p vitiki 30-01-2024 4 2 Download
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Abacavir is a nucleoside reverse transcriptase inhibitor that is used as a component of the antiretroviral treatment regimen in the management of the human immunodeficiency virus for both adults and children.
5p vigamora 23-05-2023 5 2 Download
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The clinical manifestation following methanol toxicity accounts for a life-threatening problem that contributes to metabolic disorders, neurological complications, blindness, and even death. There is no completely effective treatment to retain the patient’s vision.
5p vidoctorstrange 06-05-2023 5 2 Download
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Identifying ineffective practices that have been used in oncology is important in reducing wasted resources and harm. We sought to examine the prevalence of practices that are being used but have been shown in RCTs to be ineffective (medical reversals) in published oncology studies.
9p vimahuateng 26-11-2021 6 1 Download
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Hip fracture patients in general are elderly and they often have comorbidities that may necessitate anticoagulation treatment, such as warfarin. It has been emphasized that these patients benefit from surgery without delay to avoid complications and reduce mortality.
7p vitennessee2711 01-02-2021 11 2 Download
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Due to the recent advances in deep learning, this model attracted researchers who have applied it to medical image analysis. However, pathological image analysis based on deep learning networks faces a number of challenges, such as the high resolution (gigapixel) of pathological images and the lack of annotation capabilities.
15p vijisoo2711 27-10-2020 12 1 Download
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Health Care Workers (HCWs) are vulnerable to tuberculosis exposure. Non availability of a reliable test has resulted in underestimation of latent tuberculosis infection (LTBI) among HCWs. The aim is to detect the rate of LTBI among nursing and medical students, Compare Interferon Gamma Release Assay (IGRA) and Tuberculin Skin Test (TST), Detect conversions and reversions.
9p trinhthamhodang1215 23-09-2020 16 1 Download
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Abacavir (ABC) and Zidovudine (AZT) based regimens are the preferred first line nucleoside reverse transcriptase (NRTIs) backbones being widely utilized for managing HIV infection in children. However, there is a dearth of data regarding the clinical outcomes and associated risk factors in Ethiopia.
9p vivalanbo2711 19-03-2020 18 2 Download