Medicinal chemistry

Ebook Chemistry: An introduction for medical and health sciences provides students and practitioners with a clear, readable introduction to the chemical terms and concepts that are relevant to their study and practice. Assuming little prior knowledge of the subject the book describes and explains the chemistry underlying many of the most commonly prescribed drugs and medicines. It also includes information on chemical aspects of digestion and nutrition, oxidation, radioactivity and an overview of how chemicals fight disease.

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Building on the success of the previous editions, the Textbook of drug design and discovery, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.

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The Department of Organic Chemistry, the Department of Inorganic and Applied Chemistry, and the Department of Chemistry are among the six departments, six majors, and three research laboratories that make up the Faculty of Chemistry today, some 70 years after its founding. Physical chemistry, analytical chemistry, polymer chemistry, medicinal chemistry, and three key-research labs, including the labs for natural compounds, cancer, and computational chemistry.

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Ebook "Coupling and decoupling of diverse molecular units in glycosciences" covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry.

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Ebook "Engineering and application of pluripotent stem cells" reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. Particular attention is given to the application of the pluripotent stem cells for vascularision of engineered tissue and for drug screening.

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Ebook "Synthesis of heterocycles in contemporary medicinal chemistry" is special in several aspects. First, it was composed by industrial medicinal and process chemists with decades of industrial experience. Secondly, it is dedicated to the heterocyclic drug compounds that have particularly marked the area of medicinal chemistry over the last decade.

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Ebook "Advancing development of synthetic gene regulators: With the power of high-throughput sequencing in chemical biology" focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove.

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Ebook "SialoGlyco chemistry and biology II: Tools and techniques to identify and capture sialoglycans" provides readers with contents including: sialic acid receptors of viruses; endosialidases versatile tools for the study of polysialic acid; advanced technologies in sialic acid and sialoglycoconjugate analysis; development and applications of the lectin microarray; trypanosomal trans-sialidases valuable synthetic tools and targets for medicinal chemistry;...

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Ebook "Continuous-flow chemistry in the research laboratory: Modern organic chemistry in dedicated reactors at the dawn of the 21st century" presents a short introduction to the historical background to the field, the state of the art and a brief survey of the available instrumentation and the processing techniques used. The following major areas of interest in synthetic, organic and medicinal chemistry are elaborated on: transition-metal catalyzed reactions, organocatalytic transformations, heterocyclic synthesis, and photochemical reactions.

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Ebook "Fluorine in heterocyclic chemistry - Volume 1: 5-membered heterocycles and macrocycles" is dedicated to 5-membered fluorinated heterocycles and macrocycles. The present work combines comprehensive information on the chemistry of the fl uorinated heterocycles of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fi elds of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fl uorine chemistry.

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Ebook "Reducing drug attrition (Topics in Medicinal chemistry, Volume 11)" is to provide guidance to those persons who are dedicated to the creation and development of new drugs to aid patients. Our aim was to address the key factors that have led to failure of preclinical and clinical drug candidates. Despite the significant scientific advances over the past few decades in the disciplines associated with research and development (R&D), the overall productivity, as measured by new approved drugs, has not improved.

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Ebook "Chemistry of plant natural products: Stereochemistry, conformation, synthesis, biology, and medicine" aimed at advanced undergraduate and graduate students and researchers working with natural products, Professors Sunil and Bani Talapatra provide a highly accessible compilation describing all aspects of plant natural products.

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Ebook "Chemokines: Chemokines and their receptors in drug discovery" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

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Ebook "Dietary Chinese herbs: Chemistry, pharmacology and clinical evidence" idea came out a few years ago when the three of us, working in China, Canada, and the United States at that time, were all involved in studying or reviewing the bioactive components of dietary herbs. We realized that, although there is a large and rapidly growing body of scientific information in the literature for various Chinese herbs, it is somewhat scattered and not specific toward dietary applications.

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Ebook "Halogen bonding I: Impact on materials chemistry and life sciences" opens with a historical perspective and a basic understanding of the halogen bond and closes showing the impact that this interaction is having in various fields such as crystal engineering, supramolecular synthesis, and medicinal chemistry.

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Ebook "Halogen bonding II: Impact on materials chemistry and life sciences" presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science.

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Ebook "Nanomaterials and nanoarchitectures: A complex review of current hot topics and their applications" consists of nine contributions describing recent progress in the interdisciplinary of Nanoscience, which involves physics, chemistry, engineering, biology and medicine and one essay outlining some important historical and socioeconomic factors pertaining to recent developments in nanoscale science and technology.

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Ebook "Protein-Protein interactions (Topics in Medicinal chemistry, Volume 8)" surveys the field of inhibitors of the MDM2/p53 interaction, which essentially began with the high-profile disclosure of Nutlins, and quickly and steadily grew through programs at a number of pharmaceutical companies. The MDM2/p53 interaction constitutes a paradigm example of a relatively large, hydrophobic interaction surface for which lead compounds can easily be found.

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Ebook "Applied photochemistry" encompasses the major applications of the chemical effects resulting from light absorption by atoms and molecules in chemistry, physics, medicine and engineering, and contains contributions from specialists in these key areas. Particular emphasis is placed both on how photochemistry contributes to these disciplines and on what the current developments are.

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Ebook "Differentiation of enantiomers I (Topics in Current chemistry, Volume 340)" presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.

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