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MEP pathway
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Recent advances in single-cell techniques have provided the opportunity to finely dissect cellular heterogeneity within populations previously defined by “bulk” assays and to uncover rare cell types. In human hematopoiesis, megakaryocytes and erythroid cells differentiate from a shared precursor, the megakaryocyte-erythroid progenitor (MEP), which remains poorly defined.
19p
viaristotle
29-01-2022
7
0
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Panax ginseng C. A. Mey is one of famous medicinal herb plant species. Its major bioactive compounds are various ginsenosides in roots and rhizomes. It is commonly accepted that ginsenosides are synthesized from terpene precursors, IPP and DMAPP, through the cytoplasmic mevalonate (MVA) pathway.
14p
visilicon2711
20-08-2021
5
1
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Isoprenoids are the most ancient and essential class of metabolites produced in all organisms, either via mevalonate (MVA)-and/or methylerythritol phosphate (MEP)-pathways. The MEP-pathway is present in all plastid-bearing organisms and most eubacteria.
12p
vilichoo2711
23-06-2021
9
1
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Deoxyxylulose 5-phosphate synthase (DXS) and deoxyxylulose 5-phosphate reductoisomerase (DXR) are the enzymes that catalyze the first two enzyme steps of the methylerythritol 4-phosphate (MEP) pathway to supply the isoprene building-blocks of carotenoids.
16p
viuchiha2711
21-04-2020
5
1
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The 1-deoxyxylulose 5-phosphate reductoisomerase (DXR, EC1.1.1.267)catalyzes the conversionof 1-deoxy-D-xylulose 5-phosphate (DXP)into 2-C-methyl-D-erythritol 4-phos-phate (MEP). This transformation is a two-step process involving a rearrangement of DXP into the putative inter-mediate 2-C-methyl-D-erythrose 4-phosphate followed by a NADPH-dependent reduction of the latter aldehyde. By using [1-13 C]DXP as a substrate, the rearrangement of DXP into [5-13 C]2-C-methyl-D-erythrose 4-phosphate was shown to be NADPH dependent, although it does not involve a reduction step. ...
12p
research12
23-04-2013
34
1
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