Metabolic profiling
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This study implicated the soft coral-associated Micrococcus sp. strain A-2-28 (following relative Micrococcus flavus LW4T) for large-scale cultivation, chemical analyses, and biological activities. Whereas crude extract of the strain A-2-28 inhibited only Staphylococcus epidermidis, metabolites profiles and pure compounds from strain A-2-28 showed that this strain produced phytohormone (IAA), metabolized some new compounds which were almost inactive for biological tests.
8p dianmotminh02 03-05-2024 4 1 Download
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The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus occurs through complex organ-specific cellular mechanisms and networks contributing to impaired insulin secretion and insulin resistance. Genome-wide gene expression profiling systems can dissect the genetic contributions to metabolome and transcriptome regulations.
15p vioraclene 31-03-2024 3 2 Download
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Human pancreatic islets are a central focus of research in metabolic studies. Transcriptomics is frequently used to interrogate alterations in cultured human islet cells using single-cell RNA-sequencing (scRNAseq). We introduce single-nucleus RNA-sequencing (snRNA-seq) as an alternative approach for investigating transplanted human islets.
17p vibransone 28-03-2024 4 2 Download
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Crohn’s disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unafected controls. However, the impact of inflammation and underlying genetic risk on these microbial profiles and their relationship to disease phenotype are unclear. We used lavage sampling to characterize the colonic mucosal-luminal interface (MLI) microbiome of CD patients in endoscopic remission and unafected controls relative to obesity, disease genetics, and phenotype
20p viellison 28-03-2024 5 2 Download
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Spatiotemporal heterogeneity originating from genomic and transcriptional variation was found to contribute to subtype switching in isocitrate dehydrogenase-1 wild-type glioblastoma (GBM) prior to and upon recurrence. Fluorescence-guided neurosurgical resection utilizing 5-aminolevulinic acid (5ALA) enables intraoperative visualization of infiltrative tumors outside the magnetic resonance imaging contrast-enhanced regions.
34p vicwell 29-02-2024 4 1 Download
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Ebook "Systems biology" focuses on methodological aspects of systems biology in order to provide a new theoretical approach with a robust and tailored experimental support. Chapters detail mathematical modeling, methodological issues, modulation of the collective behavior, metabolic, dynamic profiling, and quantitative morphological studies.
372p lucchinguyen 28-12-2023 6 2 Download
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Part 2 book "Farm animal proteomics 2013" includes content: Biomarkers of winter disease in gilthead seabream - a proteomics approach, the absorption of colostral proteins in newborn lambs - an iTRAQ proteomics study, plasma proteome profiles predict diet-induced metabolic syndrome and the early onset of metabolic syndrome in a pig model, changes in protein abundance in the vertebral columnof, atlantic salmon (Salmosalar) fed variable dietary P levels,... and other contents.
129p muasambanhan02 18-12-2023 1 0 Download
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Lung cancer is one of the most lethal tumors with a poor survival rate even in those patients receiving new therapies. Metabolism is considered one of the hallmarks in carcinogenesis and lipid metabolism is emerging as a significant contributor to tumor metabolic reprogramming. We previously described a profile of some lipid metabolism related genes with potential prognostic value in advanced lung cancer.
10p vileonardodavinci 23-12-2023 2 2 Download
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Prostate cancer is a common solid tumor that affects a significant number of men worldwide. Conventional androgen deprivation therapy (ADT) increases the risk of developing castration-resistant prostate cancer (CRPC).
16p vileonardodavinci 23-12-2023 3 2 Download
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Part 1 book "Biomarkers in medicine, drug discovery, and environmental health" includes content: Biomarkers - An evolutionary perspective; genomics; proteomics for biomarker discovery; metabolic profiling for biomarker discovery; the bittersweet promise of glycobiology, biomarkers of alzheimer's and parkinson's disease; biomarkers of cardiac injury; lung injury biomarkers; translational biomarkers of acute drug induced liver injury - the current state, gaps, and future opportunities; biomarkers of acute kidney injury; in search of biomarkers for drug induced vascular injury.
336p oursky09 12-11-2023 5 3 Download
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Part 1 book "Biomarkers - In medicine, drug discovery, and environmental health" includes content: Biomarkers - An evolutionary perspective; genomics; proteomics for biomarker discovery; metabolic profiling for biomarker discovery, the bittersweet promise of glycobiology; biomarkers of Alzheimer's and Parkinson's disease; biomarkers of cardiac injury; lung injury biomarkers; translational biomarkers of acute drug induced liver injury - the current state, gaps, and future opportunities; biomarkers of acute kidney injury; in search of biomarkers for drug induced vascular injury.
336p oursky07 23-10-2023 3 1 Download
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This study attempts to identify LUAD metabolic subtypes with different characteristics and key genes based on gene transcription profiling data related to glycolysis and glutaminolysis, and to construct prognostic models to facilitate patient outcome prediction.
15p vischultz 20-10-2023 2 1 Download
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Breast cancer survivors face long-term sequelae compared to the general population, suggesting altered metabolic profiles after breast cancer. We used metabolomics approaches to investigate the metabolic differences between breast cancer patients and women in the general population, aiming to elaborate metabolic changes among breast cancer patients and identify potential targets for clinical interventions to mitigate long-term sequelae.
11p vischultz 20-10-2023 1 1 Download
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Breast cancer is associated with alterations in lipid metabolism. The treatment of breast cancer can also affect serum lipid composition. The purpose of this study was the examination of serum fatty acids (FAs) profiles in breast cancer survivors to assess if the FA levels normalize.
14p visharma 20-10-2023 3 2 Download
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We investigated the effect of fast food on diurnal lipid and carbohydrate profiles in healthy young Japanese women. Eight healthy young women with the apolipoprotein E3/3 phenotype were studied on two occasions in a randomized crossover design.
6p viisac 23-09-2023 1 1 Download
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Undernutrition is an increasingly common problem. Insufficient calorie intake and nutrient deficiencies during pregnancy may have an impact not only on the mother, but may also alter metabolism in the infant. In this study, we have applied a calorie-restricted diet during gestation and examined its effect on hepatic Fasn mRNA and DNA methylation profiles in rats and their female progeny.
8p vinarcissa 21-03-2023 1 1 Download
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Adipose tissue is recognized as a highly active metabolic and endocrine organ. The hormones secreted by this tissue play an important role in many biochemical processes. It is known that dysfunction of adipocytes can cause insulin resistance, type 2 diabetes or hyperlipidemia.
7p vinarcissa 21-03-2023 5 1 Download
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Sesame (Sesamum indicum) can accumulate over 60% oil in its seed. However, low oil content genotypes with an oil content of less than 50% are also observed. To gain insights into how genes shape this variation, we examined 22 seed and carpel transcriptomes from 3 varieties of sesame with high and low oil content.
11p vihagrid 30-01-2023 4 3 Download
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Overgrazing is a major factor that causes steppe degradation in Inner Mongolian, resulting in extensive ecosystem damage. Scarcity of grass means sheep are smaller and therefore mutton and cashmere production is greatly reduced, which has resulted in massive annual economic losses. Liver is the primary metabolic organ in mammals.
11p vihagrid 30-01-2023 5 3 Download
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In order to study the relations of hepatocellular functions, weight gain and metabolic imbalance caused by low-dose antibiotics (LDA) via epigenetic regulation of gene transcription, 32 weaned piglets were employed as animal models and randomly allocated into two groups with diets supplemented with 0 or LDA (chlorotetracycline and virginiamycin).
12p vihagrid 30-01-2023 8 3 Download