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Metabolic stability
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Ebook "Flow chemistry for the synthesis of heterocycles" provides an overview of recent developments and scope in the use of flow chemistry in relevance to heterocyclic synthesis. The heterocyclic ring is the most prominent structural motif in the vast majority of natural products as well as pharmaceutical compounds since this facilitates tuneable interactions with the biological target besides conferring a degree of structural and metabolic stability.
400p
tracanhphuonghoa1007
22-04-2024
6
3
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Part 1 book "Veterinary technician’s manual for small animal emergency and critical care" includes content: Triage and initial assessment of the emergency patient, shock and initial stabilization, venous access, monitoring the critical patient, cardiopulmonary cerebral resuscitation, cardiovascular emergencies, respiratory emergencies, gastrointestinal emergencies, urogenital emergencies, endocrine and metabolic emergencies, hemolymphatic, immunologic, and oncology emergencies.
278p
muasambanhan03
02-01-2024
3
2
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Part 1 book "Veterinary technician's manual for small animal emergency and critical care" includes content: Triage and initial assessment of the emergency patient, shock and initial stabilization, venous access, monitoring the critical patient, cardiopulmonary resuscitation, cardiovascular emergencies, respiratory emergencies, gastrointestinal, hepatobiliary, and pancreatic emergencies, urogenital emergencies, endocrine and metabolic emergencies,... and other contents.
336p
oursky07
24-10-2023
6
3
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3′-Untranslated regions (3′UTRs) play crucial roles in mRNA metabolism, such as by controlling mRNA stability, translation efficiency, and localization. Intriguingly, in some genes the 3′UTR is longer than their coding regions, pointing to additional, unknown functions.
24p
viarchimedes
26-01-2022
7
0
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N6-methyladenosine (m6 A) modification is known to impact many aspects of RNA metabolism, including mRNA stability and translation, and is highly prevalent in the brain. We show that m6 A modification displays temporal and spatial dynamics during neurodevelopment and aging.
19p
viarchimedes
26-01-2022
9
0
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The results of the physiological parameters showed that their profile changes were consistent with those of the proteome analysis. The results of the proteome and physiological parameters showed that K. candel roots could resist highsalinity stress by maintaining a normal Embden-Meyerhof-Parnas and tricarboxylic acid (EMP-TCA) pathway, increasing the activities of various antioxidant enzymes and antioxidant contents, stabilizing the cell wall structure, and accumulating secondary metabolites such as triterpenoids.
13p
thiencuuchu
27-11-2021
6
1
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: Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, cell wall stability in plants, and bone and carbohydrate metabolism in animals. The number of studies about the effect of boron in biological model systems is very limited; so far, there has been no study on the correlation between boron and amyloid-beta toxicity.
7p
thiencuuchu
27-11-2021
6
1
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Asparagine is a very important nitrogen transport and storage compound in plants due to its high nitrogen/carbon ratio and stability. Asparagine intracellular concentration depends on a balance between asparagine biosynthesis and degradation. The main enzymes involved in asparagine metabolism are asparagine synthetase (ASN), asparaginase (NSE) and serine-glyoxylate aminotransferase (SGAT).
14p
vilarryellison
29-10-2021
7
1
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Small RNAs (sRNAs) are non-coding RNAs known to regulate various biological functions such as stress adaptation, metabolism, virulence as well as pathogenicity across a wide range of bacteria, mainly by controlling mRNA stabilization or regulating translation.
16p
vijeeni2711
30-06-2021
15
1
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Flap endonuclease 1 (FEN1) is a structure-specific nuclease that plays a role in a variety of DNA metabolism processes. FEN1 is important for maintaining genomic stability and regulating cell growth and development. It is associated with the occurrence and development of several diseases, especially cancers.
14p
vianrose2711
27-04-2021
9
2
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As an important type of post-translational modification (PTM), protein glycosylation plays a crucial role in protein stability and protein function. The abundance and ubiquity of protein glycosylation across three domains of life involving Eukarya, Bacteria and Archaea demonstrate its roles in regulating a variety of signalling and metabolic pathways.
17p
vicoachella2711
27-10-2020
8
0
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Metabolic coupling of product synthesis and microbial growth is a prominent approach for maximizing production performance. Growth-coupling (GC) also helps stabilizing target production and allows the selection of superior production strains by adaptive laboratory evolution.
17p
vijisoo2711
27-10-2020
16
1
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Water deficit is one of the major abiotic stresses which adversely affect the crop growth and yield. Moisture stress induce the metabolic functions, such as reduced synthesis of photosynthetic pigments, accumulation of osmoprotectants like proline, decline in the Chlorophyll stability and alterations in physiological parameters. The Field experiment was conducted at Agricultural College and Research Institute, Madurai during summer season 2016 with the variety of SVPR - 4.
8p
trinhthamhodang1215
23-09-2020
23
1
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Despite an improvement of prognosis in breast and colon cancer, the outcome of the metastatic disease is still severe. Microevolution of cancer cells often leads to drug resistance and tumor-recurrence. To target the driving forces of the tumor microevolution, we focused on synergistic drug combinations of selected compounds.
14p
vidhaka2711
31-07-2020
10
2
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The transcription factor Nuclear factor erythroid-2-related factor 2 (NRF2) and its principal repres‑ sive regulator, Kelch-like ECH-associated protein 1 (KEAP1), are perilous in the regulation of inflammation, as well as maintenance of homeostasis.
10p
vijiraiya2711
27-05-2020
7
0
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To develop and validate a bio-analytical HPLC–MS/MS method for the determination of conivaptan (CVA) an arginine-vasopressin receptor blocker in human plasma and in rat liver microsomes (RLMs).
9p
vijiraiya2711
27-05-2020
18
2
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Vandetanib (VNT) is a new oral tyrosine kinase inhibitor that acts mainly by inhibiting vascular endothelial growth factor receptor (VEGFR). Fast, specific, sensitive and validated LC–MS/MS was established for the determination of VNT in two various matrices including rat liver microsome (RLMs) and human plasma.
8p
vijiraiya2711
27-05-2020
15
1
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Water deficit is one of the principal abiotic stresses which adversely affect the crop growth and yield. Drought induces the metabolic functions such as reduced synthesis of photosynthetic pigments, the decline in the chlorophyll stability and alternations in physiological parameters.
9p
cothumenhmong5
17-05-2020
15
1
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Mosapride belongs to class IV in Biopharmaceutics Classification System and is used in the treatment of reflux esophagitis. It exhibits poor bioavailability due to limited permeability, solubility and extensive first-pass metabolism. In this study, intranasal mosapride-loaded cross-linked xyloglucan Pluronic micelles (MOS-XPMs) was formulated and optimized to improve the low solubility & bioavailability of MOS. The solid dispersion technique using 23 full factorial design was applied. (MOS-XPMs) (F4) had the highest desirability value (0.
12p
partimesinhvien
08-05-2020
6
1
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Anthocyanins are the primary source of colour in flowers and also accumulate in vegetative tissues, where they have multiple protective roles traditionally attributed to early compounds of the metabolic pathway (flavonols, flavones, etc.).
13p
viharuno2711
21-04-2020
8
0
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