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MHC polymorphisms
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Defining hidden genetic diversity within species is of great significance when attempting to maintain the evolutionary potential of natural populations and conduct appropriate management. Our hypothesis is that isolated (and eventually small) wild animal populations hide unexpected genetic diversity due to their maintenance of ancient polymorphisms or introgressions.
9p
vinarcissa
21-03-2023
3
1
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The Major Histocompatibility Complex (MHC) is a key component of the adaptive immune system of all vertebrates and consists of the most polymorphic genes known to date. Due to this complexity, however, MHC remains to be characterized in many species including any Neotropical cichlid fish.
17p
vinarcissa
21-03-2023
5
1
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Rhodeus sinensis is a bitterling species occurring throughout the numerous freshwater systems on the East Asia. Here, we analyzed the diversity of the MHC class IIB (DAB) genes from this species, which may offer meaningful insights into evolutionary processes in this species as well as other bitterlings.
12p
vihagrid
30-01-2023
9
3
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Major histocompatibility complex (MHC) class I glycoproteins present selected peptides or antigens to CD8+T cells that control the cytotoxic immune response. The MHC class I genes are among the most polymorphic loci in the vertebrate genome, with more than twenty thousand alleles known in humans.
14p
vihagrid
30-01-2023
5
3
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The mammalian Major Histocompatibility Complex (MHC) is a genetic region containing highly polymorphic genes with immunological functions. MHC class I and class II genes encode antigen-presenting molecules expressed on the cell surface.
15p
vijeeni2711
30-06-2021
12
1
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Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown etiology. Genetic variation within different major histocompatibility complex (MHC) loci contributes to the susceptibility to IPF. The effect of 70 kDa heat shock proteins (HSP70) gene polymorphisms in the susceptibility to IPF is unknown.
8p
vimontana2711
05-04-2021
14
2
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CD4+ T-cell epitopes play a crucial role in eliciting vigorous protective immune responses during peptide (epitope)-based vaccination. The prediction of these epitopes focuses on the peptide binding process by MHC class II proteins. The ability to account for MHC class II polymorphism is critical for epitope-based vaccine design tools, as different allelic variants can have different peptide repertoires.
11p
viwyoming2711
16-12-2020
20
1
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The highly polymorphic gene of the MHC is central molecule in immune system in recognition of pathogens and parasites. The purpose of this study was to study the polymorphism of CLA-DRB3 gene in Salem black goat using PCR-RFLP technique.
6p
caygaocaolon2
14-03-2020
10
1
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Similar MHC class II polymorphisms and T cell dysfunc- tions have been implicated in lupus,[127,128] and lower levels of free tryptophan[129] and MHC II protein over expression is also linked to autoimmune attack on beta cells in Type I diabetes (IDDM) [130]. Over expression of the MHC II following failure to select against self-reactive T-cells is also a useful model for rheumatoid arthritis, Graves disease, and Hashimoto's thyroiditis, in which T- cells react to proteins produced in the body, failing to dis- criminate them from invading organisms [131].
7p
thankinhphanliet
20-12-2012
53
7
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