Microbial activity

Croton tonkinensis has been a focal point of medicinal research due to its rich phytochemical composition, particularly ent-kaurane diterpenoids. These compounds exhibit diverse biological activities, including anticancer, anti-inflammatory, anti-microbial, and osteogenic effects, which are explored in this review.

6p viyamanaka 06-02-2025 1 1   Download

Researching objectives: Evaluating the diversity and using values of essential oil plants at Ben En National Park, Thanh Hoa province; determining the content and composition of essential oils of some plant species; determinating the anti-mosquito and anti-microbial activities of essential oils of Zingiber zerumbet (L.) Smith.

27p capheviahe27 23-02-2021 30 4   Download

A field experiment was conducted at main research farm of OUAT, Bhubaneswar, Odisha. The experiment was laid out in double split design with 27 treatment combinations and three replications. In main plot sunflower residue was removed in one plot, incorporated in another plot and in third plot no sunflower was grown. In subplot three methods of establishment of rice was taken namely dry direct seeded, wet direct seeded and transplanting method of rice establishment.

8p angicungduoc6 22-07-2020 24 3   Download

A pot culture experiment was conducted to study the effect of humic acid on soil microbial population and enzymatic activity in groundnut in an Alfisol at Main Agricultural Research Station, Dharwad.

5p gaocaolon5 14-06-2020 7 2   Download

The present study was aimed to investigate the phytochemical screening and antimicrobial activities of Calotropis gigantea leaf extracts. In addition to these studies we also check the effect of UV light radiation on the anti microbial activity of leaf extract.

8p tocectocec 25-05-2020 25 1   Download

Researching objectives: Evaluating the diversity and using values of essential oil plants at Ben En National Park, Thanh Hoa province. Determining the content and composition of essential oils of some plant species. Determinating the anti-mosquito and anti-microbial activities of essential oils of Zingiber zerumbet (L.) Smith.

27p xacxuoc4321 08-07-2019 38 3   Download

a-Sarcin, a cyclizing ribonuclease secreted by the mould Aspergillus giganteus, is one of the best characterized members of a family of fungal ribotoxins. This protein induces apoptosis in tumour cells due to its highly specific activity on ribosomes. Fungal ribotoxins display a threedimensional protein fold similar to those of a larger group of microbial noncytotoxic RNases, represented by RNases T1 and U2.

7p system191 01-06-2013 27 3   Download

Dendrimeric peptides selective for microbial surfaces have been developed to achieve broad antimicrobial activity and low hemolytic activity to human erythrocytes. The dendrimeric core is an asymmetric lysine branching tethered with two to eight copies of a tetrapeptide (R4) or an octapeptide (R8). The R4 tetrapeptide (RLYR) contains a putative microbial surface recognition BHHB motif (B ¼ basic, H ¼ hydrophobic amino acid) found in protegrins and tachyplesins whereas the octapeptide R8 (RLYRKVYG) consists of an R4 and a degenerated R4 repeat....

10p research12 01-06-2013 41 6   Download

Gaegurin 4 (GGN4), a 37-residue antimicrobial peptide, consists of two amphipathic ahelices (residues 2–10and 16–32) connected by a flexible loop region (residues 11– 15). As part of an effort to develop new peptide antibiotics with low molecular mass, the activities of C-terminally truncated GGN4 analogues were tested. D 24)37 GGN4, a peptide analogue with 14 residues truncated from the C-terminus of GGN4, showed a complete loss of anti-microbial activity.

8p research12 23-04-2013 31 2   Download

The serotype a-specific polysaccharide antigen ofActinoba-cillus actinomycetemcomitansis an unusual sugar, 6-deoxy-D-talose.Guanosinediphosphate (GDP)-6-deoxy-D-talose is the activated sugar nucleotide form of 6-deoxy-D-talose, which has been identified as a constituent of only a few microbial polysaccharides. In this paper, we identify two genes encoding GDP-6-deoxy-D-talose synthetic enzymes, GDP-a-D-mannose 4,6-dehydratase and GDP-4-keto-6-deoxy-D-mannose reductase, in the gene cluster required for the biosynthesis of serotype a-specific polysaccharide anti-gen from A.

9p tumor12 22-04-2013 32 2   Download

Lactoferrin (LF) is a Fe 3+ -binding glycoprotein, first recognized in milk and then in other human epithelial secretions and barrier fluids. Many different functions have been attributed to LF, including protection from iron-induced lipid peroxidation, immunomodulation and cell growthregulation, DNA binding, and transcriptional acti-vation. Its physiological role is still unclear, but it has been suggested to be responsible for primary defense against microbial and viral infection.

9p tumor12 20-04-2013 38 3   Download

GE23077, a novel microbial metabolite recently isolated from Actinomadurasp. culture media, is a potent and selective inhibitor of bacterial RNApolymerase (RNAP). It inhibitsGram-positive (Bacillus subtilis) andGram-negative (Escherichia coli)RNAPs with IC50 values (i.e. the concen-tration at which the enzyme activity is inhibited by 50%) in the 10 )8 Mrange, whereas it is not active onE. coliDNA polymerase or on eukaryotic (wheat germ) RNAP II (IC50 values10 )4 Min both cases).

0p awards 05-04-2013 56 2   Download

Antimicrobial peptides are effector molecules of the innate immune system. We recently showed that the human anti-microbial peptidesa-defensin and LL-37 bind to glycos-aminoglycans (heparin and dermatan sulphate). Here we demonstrate the obverse, i.e. structural motifs associated with heparin affinity (cationicity, amphipaticity, and con-sensus regions)may confer antimicrobial properties to a given peptide.

8p dell39 03-04-2013 38 3   Download

We recently discovered several nonlysine-analog conforma-tional modulators for plasminogen. These include SMTP-6, thioplabin B and complestatin that are low molecular mass compounds of microbial origin. Unlike lysine-analog mod-ulators,which increaseplasminogenactivationbut inhibit its binding to fibrin, the nonlysine-analog modulators enhance both activation and fibrin binding of plasminogen.

12p dell39 03-04-2013 31 4   Download

Triticum aestivum xylanase inhibitor (TAXI)-type inhibitors are active against microbial xylanases from glycoside hydrolase family 11, but the inhibition strength and the specificity towards different xylanases differ between TAXI isoforms. Mutational and biochemical analyses of TAXI-I, TAXI-IIA andBacillus subtilisxylanase A showed that inhibition strength and specificity depend on the identity of only a few key residues of inhibitor and xylanase [Fierens K et al. (2005) FEBS J272, 5872–5882; Raedschelders Get al....

12p vinaphone15 25-02-2013 31 2   Download

Hirsutellin (HtA) is intermediate in size between other ribotoxins and less specific microbial RNases, and thus offers a unique chance to determine the minimal structural requirements for activities unique to ribotoxins. Here, we have determined the structure of HtA by NMR methods.

10p viettel02 22-02-2013 22 3   Download

Antimicrobial peptides participate in innate host defense by directly elimi-nating pathogens as a result of their ability to damage the microbial mem-brane and by providing danger signals that will recruit innate immune cells to the site of infection. Dermaseptin DA4 (DRS-DA4), a new antimicrobial peptide of the dermaseptin superfamily, was identified based on its chemo-tactic properties, contrasting with the currently used microbicidal proper-ties assessment.

14p viettel02 20-02-2013 39 3   Download

Whereas significant knowledge is accumulating on the antibacterial and antifungal properties of host defense peptides (HDPs) and their synthetic mimics, much less is known of their activities against parasites. A variety ofin vitro andin vivo antiparasitic assays suggest that these notorious anti-microbial compounds could represent a powerful tool for the development of novel drugs to fight parasites in the vertebrate host or to complement current therapeutic strategies

9p viettel02 20-02-2013 45 3   Download

Antimicrobial peptides constitute one of the main classes of molecular weapons deployed by the innate immune system of all multicellular organisms to resist microbial invasion. A good proportion of all antimi-crobial peptides currently known, numbering hundreds of molecules, have been isolated from frog skin.

18p viettel02 20-02-2013 32 3   Download

Microbial pathogens exploit the ubiquitin system to facilitate infection and manipulate the immune responses of the host. In this study, susceptibility to Yersinia enterocolitica and Yersinia pseudotuberculosis invasion was found to be increased upon overexpression of the deubiquitinating enzyme otubain 1 (OTUB1), a member of the ovarian tumour domain-containing protein family.

16p mobifone23 21-01-2013 49 6   Download