Minimum subset of genes

The advances in target control of complex networks not only can offer new insights into the general control dynamics of complex systems, but also be useful for the practical application in systems biology, such as discovering new therapeutic targets for disease intervention. In many cases, e.g. drug target identification in biological networks, we usually require a target control on a subset of nodes (i.e., disease-associated genes) with minimum cost, and we further expect that more driver nodes consistent with a certain well-selected network nodes (i.e., prior-known drug-target genes).

13p vilarryellison 29-10-2021 12 2   Download

Previous studies on tumor classification based on gene expression profiles suggest that gene selection plays a key role in improving the classification performance. Moreover, finding important tumor-related genes with the highest accuracy is a very important task because these genes might serve as tumor biomarkers, which is of great benefit to not only tumor molecular diagnosis but also drug development.

26p viwyoming2711 16-12-2020 6 2   Download

Microarray technology, as well as other functional genomics experiments, allow simultaneous measurements of thousands of genes within each sample. Both the prediction accuracy and interpretability of a classifier could be enhanced by performing the classification based only on selected discriminative genes.

20p vikentucky2711 26-11-2020 14 2   Download

Feature selection, aiming to identify a subset of features among a possibly large set of features that are relevant for predicting a response, is an important preprocessing step in machine learning. In gene expression studies this is not a trivial task for several reasons, including potential temporal character of data.

14p vioklahoma2711 19-11-2020 13 1   Download

The objectives of Alberta Environment’s approach to setting wastewater release standards are to ensure water quality objectives are maintained, that appropriate pollution prevention and control technologies are adopted so that substance releases to receiving waters are minimized. Two standards are developed to assess the limit that should be applied in an approval: one standard is based on best available technology economically achievable, and the second is based on maintaining water quality objectives. The technology-based standard is the minimum effort required. ...

52p loixinloi 08-05-2013 50 3   Download