![](images/graphics/blank.gif)
Mitochondrial dysfunction
-
Ebook "Mitochondria and cancer" presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins.
294p
ladongphongthanh1008
22-04-2024
3
1
Download
-
Ebook "Folding for the synapse" addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an isolated moiety or part of a protein complex.
315p
tracanhphuonghoa1007
22-04-2024
3
2
Download
-
Several articles suggest that DNA methylation levels in blood relate to Parkinson’s disease (PD) but there is a need for a large-scale study that involves suitable population based controls.
12p
vioraclene
31-03-2024
4
1
Download
-
Part 2 book "Biomarkers in medicine, drug discovery, and environmental health" includes content: Biomarkers of immunotoxicity; biomarkers in obstetric medicine; biomarkers in cancer, biomarkers of HIV, biomarkers of in vitro drug induced mitochondrial dysfunction, immunoassay based technologies for the measurement of biological materials used for biomarkers discovery and translational research, nanoscale techniques for biomarker quantification, immunodiagnostics with a focus on lateral flow point of care devices,.... and other contents.
312p
oursky09
12-11-2023
3
2
Download
-
Part 2 book "Biomarkers - In medicine, drug discovery, and environmental health" includes content: Biomarkers of immunotoxicity; biomarkers in obstetric medicine; biomarkers in cancer; biomarkers of HIV; biomarkers of in vitro drug induced mitochondrial dysfunction; immunoassay based technologies for the measurement of biological materials used for biomarkers discovery and translational research; nanoscale techniques for biomarker quantification; immunodiagnostics with a focus on lateral flow point of care devices,... and other contents.
312p
oursky07
23-10-2023
7
1
Download
-
Mitochondrial DNA (mtDNA) mutations frequently manifest with multisystem disease, including cardiomyopathy (CM). Various studies described mutations in protein-encoding mtDNA genes, such as cytochrome-b, manifesting with CM. A detailed clinical, biochemical, and molecular genetic analysis was performed in a 40-year-old male with dilated CM (DCM) to detect the underlying mtDNA defect.
5p
viintuit
26-09-2023
2
0
Download
-
Mitochondrial cytopathies are characterized by a large variability of clinical phenotypes and severity. The amount of mutant mitochondrial DNA (mtDNA) in a cell, called the heteroplasmy level, is an important determinant of the degree of mitochondrial dysfunction and therefore disease severity.
8p
vinarcissa
21-03-2023
2
1
Download
-
Parkinson's disease is a neurodegenerative disease that is characterized by the loss of dopaminergic neurons. Fucoidan, which has emerged as a neuroprotective agent, is a marine-origin sulfated polysaccharide enriched in brown algae and sea cucumbers.
13p
vihermione
30-12-2022
68
2
Download
-
Esophageal squamous cell carcinoma (ESCC) is the most predominant primary malignant tumor among worldwide, especially in China. To date, the successful treatment remains a mainly clinical challenge, it is imperative to develop successful therapeutic agents.
11p
vielonmusk
21-01-2022
14
0
Download
-
Inhalation of sevoflurane can induce neuronal apoptosis, cognitive impairment and abnormal behaviors. Bone marrow mesenchymal stem cells (MSCs) can secret neurotrophic factors and cytokines to protect from oxidative stress-related neuronal apoptosis. However, whether MSCs can protect from sevoflurane-induced neuronal apoptosis and the potential mechanisms are unclear.
9p
vampires36
30-12-2021
8
0
Download
-
Adipose tissue is a major endocrine organ and is thought to play a central role in the metabolic control of reproductive function in cattle. Plane of nutrition during early life has been shown to influence the timing of puberty in both male and female cattle, though the exact biological mechanisms involved are currently unknown. The aim of this study was to investigate the effect of early calf-hood nutrition on the transcriptomic profile of subcutaneous adipose tissue in Holstein-Friesian bulls to identify possible downstream effects on reproductive physiology.
12p
vibeauty
23-10-2021
12
1
Download
-
Fatty liver disease prevalently occurs in commercial postpartum dairies, resulting in a worldwide high culling rate because of their subsequent limitations of production and reproduction performance.
16p
vitzuyu2711
29-09-2021
20
1
Download
-
Cumulative evidence indicates that statins induce myotoxicity. However, the lack of understanding of how statins affect skeletal muscles at the structural, functional, and physiological levels hampers proper healthcare management. The purpose of the present study was to investigate the early after-effects of lovastatin on the slowtwitch soleus (Sol) and fast-twitch extensor digitorum longus (EDL) muscles.
7p
vitennessee2711
02-02-2021
17
2
Download
-
Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether intra-articular administration of oligomycin, an inhibitor of mitochondrial function, induces an oxidative and inflammatory response in rat knee joints.
12p
vitennessee2711
02-02-2021
8
1
Download
-
Visceral obesity has a strong association with both the incidence and mortality of esophageal adenocarcinoma (EAC). Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer, however, the potential role that obesity plays in driving these alterations in EAC is currently unknown.
11p
vilisa271
22-09-2020
9
0
Download
-
Colorectal cancer (CRC) is a major global public health problem and the second leading cause of cancer-related death. Mitochondrial dysfunction has long been suspected to be involved in this type of tumorigenesis, as supported by an accumulating body of research evidence.
12p
vimanama2711
30-07-2020
16
2
Download
-
COPD patients are at increased risk of developing non-small cell lung carcinoma that has a worse prognosis. Oxidative stress contributes to carcinogenesis and is increased in COPD patients due to mitochondrial dysfunction.
9p
viputrajaya2711
22-06-2020
15
1
Download
-
Genipin is a compound derived from gardenia fruit extract. Although Genipin has anti-tumor effects in various cancers, its effect and mechanism in gastric cancer remain unclear.
12p
vikuala271
13-06-2020
8
1
Download
-
Lactic acidosis is a common finding in neonates, in whom mitochondrial dysfunction is often secondary to tissue hypoperfusion, respiratory failure, and/or sepsis. Primary (non-physiological) lactic acidosis is comparatively rare, and suggests the presence of an inborn error of mitochondrial energy metabolism.
4p
viorochimaru2711
29-05-2020
12
0
Download
-
Mitochondrial DNA (mtDNA) is present in multiple copies per cell and undergoes dramatic amplification during development. The impacts of mtDNA damage incurred early in development are not well understood, especially in the case of types of mtDNA damage that are irreparable, such as ultraviolet C radiation (UVC)-induced photodimers.
14p
vienzym2711
03-04-2020
6
0
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)