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Mitochondrial homeostasis
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Ebook "Mitochondria and cell death" examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity.
242p
tracanhphuonghoa1007
22-04-2024
2
2
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Ebook "Protein metabolism and homeostasis in aging (Advances in experimental medicine and biology, Volume 694)" provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data.
268p
duongthandue0501
28-02-2024
1
1
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Ebook "Mitochondrial DNA and diseases" describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing.
233p
lucchinguyen
28-12-2023
6
2
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Leucine-rich pentatricopeptide repeat containing (LRPPRC) is a potential oncogene in multiple tumor types, including lung adenocarcinoma, esophageal squamous cell carcinoma and gastric cancer. LRPPRC exerts its tumor-promoting effects mainly by regulating mitochondrial homeostasis and inducing oxidative stress.
11p
visharma
20-10-2023
4
2
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Apoptosis-inducing factor (AIF), named for its involvement in cell death pathways, is a mitochondrial protein that regulates metabolic homeostasis. In addition to supporting the survival of healthy cells, AIF also plays a contributory role to the development of cancer through its enzymatic activity, and we have previously shown that AIF preferentially supports advanced-stage prostate cancer cells.
15p
vinaypyidaw2711
26-08-2020
7
2
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This study reports the results of a meta-analysis that was performed: To compare HtrA1 expression as mRNA and protein, in cancer tissue versus non-cancer tissue and to assess overall survival in relation to low or medium-high HtrA1 tissue expression.
9p
vibaku2711
22-07-2020
17
1
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Mitochondrial diseases are a heterogeneous group of disorders that are currently the focus of intense research. The many cell functions performed by mitochondria include ATP production, calcium homeostasis, and apoptosis.
16p
sony2711
28-01-2019
16
2
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When studiedin vitro, mitochondrial permeability transition (MPT) is associated with an increase in mitochondrial per-meability to solutes up to 1500 Da in mass and a loss of electrical potential difference across the inner mitochondrial membrane (Dwmit). The MPT has been implicated as being important in cellular calcium homeostasis, autophagy and cell death via necrosis and apoptosis.
8p
research12
23-04-2013
45
2
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The development of targeted probes (based on the molecular engineering of luminescent or fluorescent proteins) has allowed the specific measure-ment of [Ca 2+ ] in intracellular organelles or cytoplasmic subdomains. This approach gave novel information on different aspects of cellular Ca 2+ homeostasis. Regarding mitochondria, it was possible to demonstrate that, upon physiological stimulation of cells, Ca 2+ is rapidly accumulated in the matrix.
10p
fptmusic
11-04-2013
40
1
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Adaptations of the kinetic properties of mitochondria in striated muscle lacking cytosolic (M) and⁄or mitochondrial (Mi) creatine kinase (CK) iso-forms in comparison to wild-type (WT) were investigated in vitro. Intact mitochondria were isolated from heart and gastrocnemius muscle of WT and single- and double CK-knock-out mice strains (cytosolic (M-CK –⁄ – ), mitochondrial (Mi-CK –⁄ – ) and double knock-out (MiM-CK –⁄ – ), respect-ively).
10p
awards
05-04-2013
36
3
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Three pairs of parental (q + ) and established mitochondrial DNAdepleted (q 0 ) cells, derived frombone, lungandmuscle were used to verify the influence of the nuclear background and the lack of efficient mitochondrial respiratory chain on antioxidant defences and homeostasis of intracellular reactive oxygen species (ROS).
11p
awards
05-04-2013
39
2
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Cell death by the process of apoptosis plays important roles in development, tissue homeostasis, diseases and drug responses. The cysteine aspartyl prote-ase caspase-9 plays a central role in the mitochondrial or intrinsic apoptotic pathway that is engaged in response to many apoptotic stimuli.
11p
viettel02
20-02-2013
32
1
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Frataxin, a conserved mitochondrial protein implicated in cellular iron homeostasis, has been involved as the iron chaperone that delivers iron for the Fe–S cluster and heme biosynthesis. However, its role in iron metabo-lism remains unclear, especially in photosynthetic organisms.
12p
mobifone23
07-01-2013
34
3
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