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Mitogen activated kinase 4
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Cancerous inhibitor of PP2A (CIP2A) is a recently characterized oncoprotein, which promotes cancer cell proliferation. But the role of CIP2A in lung cancer progression is still not well understood. Methods: The expression level of CIP2A in lung cancer tissues was examined by immunohistochemistry. CIP2Aassociated cell proliferation was performed by knock down or overexpression of CIP2A in lung cancer cells.
11p
vimoscow2711
29-08-2020
17
2
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Currently, the major treatment modalities of advanced melanoma are immune check point and mitogen-activated protein kinase (MAPK) pathway inhibitors.
10p
viputrajaya2711
22-06-2020
8
0
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Acidic extracellular pH is a common feature of tumor tissues. We have reported that culturing cells at acidic pH (5.4–6.5) induced matrix metallo-proteinase-9 expression through phospholipase D, extracellular signal regu-lated kinase 1⁄2 and p38 mitogen-activated protein kinases and nuclear factor-jB.
13p
galaxyss3
19-03-2013
30
3
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InArabidopsis thaliana, the serine⁄threonine protein kinase oxidative signal-inducible 1 (OXI1), mediates oxidative stress signalling. Its activity is required for full activation of the mitogen-activated protein kinases (MAP-Ks), MPK3 and MPK6, in response to oxidative stress.
11p
cosis54
05-01-2013
39
1
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