MM cell
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Ebook "Advances in biology and therapy of multiple myeloma - Volume 1: Basic science" despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.
322p duongthandue0501 28-02-2024 3 1 Download
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To evaluate the results of Mohs Micrography Surgery (MMS) in the treatment of basal cell carcinoma (BCC). Materials and methods: We used the database of PUBMED and EMBASE to evaluate the results of MMS in treatment of BCC.
8p vigojek 02-02-2024 2 1 Download
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Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as surgery, chemotherapy, and radiotherapy. Our previous studies have suggested that tumor cell-derived connective tissue growth factor (CTGF) regulates the proliferation of MM cells as well as the tumor growth in mouse xenograft models.
12p vialfrednobel 23-12-2023 8 4 Download
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B cell maturation antigen (BCMA) targeted immunotherapies have demonstrated remarkable clinical efficacy in multiple myeloma (MM). Here, we evaluated the BCMA expression in MM and other plasma cell dyscrasias (PCDs), hoping to provide a potential treatment strategy for the relapsed/refractory PCDs besides MM.
9p vischultz 20-10-2023 1 1 Download
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Upfront high-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) remains a profitable strategy for newly diagnosed multiple myeloma (MM) patients in the context of novel agents.
13p visharma 20-10-2023 3 2 Download
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Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cells. The diagnosis of this disease is often suspected through a constellation of clinical signs and symptoms of hypercalcemia, renal failure, anemia, and M-spike proteins.
4p viintuit 26-09-2023 3 0 Download
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Primary plasma cell leukemia (PPCL) is a rare form of multiple myeloma (MM) and is a rare aggressive disease with a median overall survival of 6 - 11 months. We present a case of acute hyperammonemic encephalopathy as the initial presentation of PPCL in a 78-yearold woman to highlight an atypical presentation of this disorder.
4p viintuit 26-09-2023 2 0 Download
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Synchronous or metachronous multiple primary malignancies (MPMs) are a known phenomenon. These occurrences may be spontaneous or related to environmental risk factors or genetic predisposition. Chronic myelogenous leukemia (CML) and Multiple myeloma (MM) are two uncommon hematologic malignancies, arises from two different cell lineage.
6p videadpool 05-05-2023 6 2 Download
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Bài viết này trình bày kết quả nghiên cứu ban đầu khi áp dụng phương pháp thí nghiệm nén tĩnh O-cell cho cọc khoan nhồi đường kính nhỏ, với cọc đường kính 600 mm và 800 mm. Sức chịu tải của cọc được xác định từ thí nghiệm theo phương pháp Osterber truyền thống và phương pháp cải tiến.
5p chieuchieu03 25-04-2023 10 2 Download
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Gold nanoparticles (AuNPs) with average particle sizes of 13.3 nm were synthesized by γrays irradiation of 1.0 mM Au3+ solutions using low molecular weight β-glucan extracted from yeast cell wall as a stabilizer. The UV-Vis spectra and TEM images were used to analyze the optical characteristic and particle size of AuNPs.
6p vicedric 08-02-2023 2 1 Download
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The objectives of this study were to prove the control of the lake water quality in terms of turbidity, total suspended solid (TSS), chemical oxygen demand (COD), and number of the algal cells by using the Riplox-based chemical complex (including (Ca(NO3)2) and (FeCl3) at concentrations ranging from 5 mM to 50 mM, with the presence of CuSO4 4 mg/L), considering the effects of the chemical fraction, the chemical concentration, and the treatment time.
8p vimalfoy 08-02-2023 3 2 Download
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Multiple myeloma remains an incurable disease with multiple relapses due to residual myeloma cells in the bone marrow of patients after therapy. Presence of small number of cancer cells in the body after cancer treatment, called minimal residual disease, has been shown to be prognostic for progression-free and overall survival.
11p vipriyankagandhi 27-07-2022 9 1 Download
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A rhodamine B derivative containing 1,2,4-triazole as subunit was characterized as an “off–on” type Cu2+ - selective fluorescent probe. It exhibited high selectivity and sensitivity for Cu2+ in ethanol–water solution (9:1, v:v, pH 7.0, 20 mM HEPES) and underwent ring opening. A prominent fluorescence enhancement at 570 nm was observed in the presence of Cu2+ with the change in the absorption spectrum, and a 1:1 metal–ligand complex was formed.
7p langthannam 29-12-2021 10 0 Download
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A fluorescent probe based on benzoyl hydrazine was synthesized and characterized as an Al3+-selective fluorescent probe. This probe showed good selectivity towards Al 3+ compared to other common ions. Under optimized experimental conditions, the probe exhibited a linear dynamic response for Al 3+ from 5.0 × 10−7 to 4.5 × 10−6 M with a detection limit of 1.3 × 10−7 M in ethanol–water solution (9:1, v:v, pH 6.8, 20 mM HEPES). Furthermore, it was used for imaging of Al3+ in living cells with satisfying results.
9p langthannam 29-12-2021 6 0 Download
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The evidence for a complete cellular remnant removal was shown through Hematoxylin and Eosin staining and DNA measurements. The AAM powder was prepared by mechanical disruption under reduced temperatures, which resulted in an AAM particle size in the range of 100 mm. In vitro cytotoxicity testing via extraction demonstrated that AAM had no toxicity on human adipose derived stem cells (hADSCs).
10p meyerowitz 25-12-2021 9 0 Download
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: In this study, magnetic O-carboxymethyl chitosan (MOCC) nanocomposite was synthesized and characterized as a drug delivery system for loading the anticancer drug irinotecan (CPT-11). To increase the drug loading capacity, MOCC was synthesized by linking the carboxyl group functionally to chitosan. Also, several critical factors such as concentration, the dose of MOCC, and contact time for optimum drug loading condition were investigated. The loading capacity of CPT-11 onto MOCC was calculated as 5.6 mg/g, and the loaded drug concentration was calculated as 0.04787 mM at pH value of 5.
11p tudichquannguyet 29-11-2021 8 1 Download
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Approximately 20% of MM patients harbor glucocorticoid (GC) resistance and are not responsive to therapeutic effect. Chaperoneheat-shock proteins Hsp90 is needed for ligand docking, The imbalance of Hsp90/GRα (glucocorticoid receptor α) may be an important cause of GC resistance.
7p vimahuateng 26-11-2021 15 1 Download
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Follicle selection in chickens refers to the process of selecting one follicle from a group of small yellow follicles (SY, 6–8 mm in diameter) for development into 12–15 mm hierarchical follicles (usually F6 follicles), which is an important process affecting laying performance in the poultry industry.
12p vijeeni2711 24-07-2021 12 1 Download
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Aedes aegypti is the principle vector of many arboviruses, including dengue virus and Zika virus, which are transmitted when an infected female mosquito takes a blood meal in order to initiate vitellogenesis. During blood digestion, ~ 10 mM heme-iron is ingested into the midgut lumen.
20p vijeeni2711 30-06-2021 6 1 Download
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Side population (SP) cells, which have similar features to those of cancer stem cells, show resistance to dexamethasone (Dex) treatment. Thus, new drugs that can be used in combination with Dex to reduce the population of SP cells in multiple myeloma (MM) are required.
10p vianrose2711 27-04-2021 15 1 Download